Keratoconus Diagnosis and Treatment: Recent Advances and Future Directions

Abstract

Keratoconus is a disorder characterized by progressive corneal thinning and steepening that may result in significant visual impairment secondary to high astigmatism, corneal scarring, or even corneal perforation. Early detection and screening of keratoconus are essential for effective management and treatment. Several screening methods, such as corneal topography and tomography, corneal biomechanics, and genetic testing, are being developed to detect keratoconus at an early stage. Once detected, prevention of progression is the mainstay of keratoconus management. Corneal collagen cross-linking is a minimally invasive treatment option that can slow or halt the progression of keratoconus. Additionally, recent studies have investigated the potential use of copper sulfate eye drops (IVMED-80) and extracellular vesicles to prevent the progression of keratoconus as non-invasive treatment options. For visual rehabilitation, currently available treatments include scleral lenses, intracorneal ring segments, corneal allogenic intrastromal ring segments, and deep anterior lamellar keratoplasty. The safety and efficacy of these emerging treatment options for keratoconus are currently being investigated.

Keywords:

• keratoconus
• corneal cross-linking
• intracorneal ring segments
• deep anterior lamellar keratoplasty
• IVMED-80
• extracellular vesicles

Disclosure

Dr Neel Pasricha reports personal fees from Iota Biosciences, Vanda Pharmaceuticals and Zeiss, outside the submitted work. The authors report no other conflicts of interest in this work.