Compensatory Corneal Epithelial Changes After Femtolaser - Assisted Intracorneal Rings Implantation in Early and Moderate Cases of Keratoconus

Abstract

Purpose

To study the compensatory corneal epithelial changes after femtolaser-assisted intracorneal ring segment (ICRS) implantation in early and moderate cases of keratoconus (KC) using anterior segment optical coherence tomography (AS-OCT).

Patients and Methods

A prospective observational non-randomized study of 40 eyes with mild to moderate KC received femtolaser-assisted ICRS implantation. Ferrara ICRS with different arc lengths and thicknesses were used according to the patients’ tomographic pattern. Patients had a clear central cornea, keratometry reading < 60 diopters, and corneal thickness > 400 microns. AS-OCT was performed preoperatively and at 1, 3, and 6 months after surgery. Corneal epithelial thickness (CET) was measured over 17 points (2 mm central and 16 points on 2–5 mm and 5–7 mm annular zones) over the pupil center. All data were collected and analyzed.

Results

Comparing the preoperative and postoperative data, there was a statistically significant increase in the CET postoperatively throughout the 6-month follow-up period in all zones (p<0.001). The epithelial thickness (ET) was noticed shortly around and central to the ring ridges by the first month (5–7 mm zone). By the third month, the flattened central cornea (2 mm zone) and the 2–5 mm zone showed a significant increase in ET up to the 6th month.

Conclusion

ICRS implantation in KC results in a thicker and more regular epithelium in the central corneal zone as a secondary response to the corneal stromal changes induced by the implants.

Keywords:

• keratoconus
• Ferrara rings
• epithelial thickness
• AS-OCT

Abbreviations

KC, Keratoconus; AS-OCT, Anterior segment optical coherence tomography; ICRS, Intracorneal ring segments; CET, Corneal epithelial thickness; ET; Epithelial thickness; CXL, corneal crosslinking. CAIRS, Corneal Allogenic Intrastromal Ring Segments.

Acknowledgments

The authors thank Professor Dr. Mustafa El Hossini, Professor of Community and Public Health, Faculty of Medicine, Ain University, for helping with the statistics of this study.

Disclosure

The authors report no conflicts of interest in this work.

Additional information

Funding

There is no funding to report.