Head-to-Head Comparison of Intermediate Vision of Two Monofocal Intraocular Lenses

Abstract

Purpose

To compare intermediate visual outcomes in patients previously implanted with bilateral Clareon monofocal IOLs versus bilateral Eyhance IOLs.

Methods

This was a non-interventional, single-center, examiner-masked, comparative study. Participants were cataract patients presenting at least 3 months after uncomplicated, bilateral implantation of either Clareon or Eyhance non-toric and toric IOLs. Outcomes measures included binocular distance-corrected intermediate visual acuity (DCIVA), binocular corrected distance visual acuity (CDVA), binocular best-corrected defocus curve, postoperative mean residual spherical equivalent (MRSE), and residual astigmatism.

Results

A total of 620 eyes of 310 subjects (155 subjects per group) were evaluated. The mean difference in DCIVA was 0.05 logMAR between the Eyhance and Clareon IOLs which was significant (p < 0.01), but within the 0.1 logMAR non-inferiority margin. Mean CDVA of the Clareon group was 0.01 ± 0.03 logMAR compared to 0.02 ± 0.03 logMAR of the Eyhance Group (p > 0.05). Defocus curves from +1.0 D to –3.0 D were not clinically nor statistically different between the Clareon and Eyhance groups (p > 0.05).

Conclusion

The results of this study show that bilateral implantation of Clareon monofocal IOLs and Eyhance monofocal IOLs lead to similar distance and intermediate visual outcomes.

Plain Language Summary

The natural lens inside the eye can become opaque. Cataract surgery removes this lens and replaces it with an artificial intraocular lens (IOL). The most often used type of intraocular lenses are monofocal lenses. These lenses provide clear vision for viewing distant objects. Increasing attention is also being paid to how these monofocal lenses perform for viewing objects at intermediate distances (such as using a digital device). The purpose of this study was to compare visual outcomes in patients with bilateral implantation of two different types of monofocal lenses, one of which was specifically designed to increase depth of focus. The results of this study suggest that implantation with these monofocal IOLs led to similar visual outcomes and that both monofocal IOLs may provide a similar potential to improve vision at the intermediate range.

Keywords:

• Clareon
• Eyhance
• monofocal
• intermediate visual acuity

Acknowledgments

This paper was presented at the 2023 American Society of Cataract and Refractive Surgery (ASCRS) Annual Meeting as a conference talk with interim findings. An industry trade article was published that referenced some of the presented data (https://crstodayeurope.com/articles/monofocal-iols-impact-of-optical-design-on-intermediate-vision/monofocal-iols-impact-of-optical-design-on-intermediate-vision).

Disclosure

J. Morgan Micheletti, MD, is a consultant for Alcon, and reports the following outside the submitted work: Alcon – Consultant, Speaker, Research Grant; Bausch & Lomb – Consultant; BVI – Consultant; Johnson & Johnson Vision – Research Grant; Lenstec – Speaker; RxSight – Consultant, Speaker; Zeiss – Consultant. Brad Hall reports that he has received consulting fees from Ace Vision Group outside the submitted work. The authors report no other conflict of interest for this work.

Additional information

Funding

This study was supported with an investigator-initiated study grant (69901155) from Alcon Vision, LLC, Fort Worth, TX, USA.