A Case Study of Gastric Adenocarcinoma and Squamous Cell Carcinoma of the Cervix

Abstract

Gastric adenocarcinoma (GAS) is a rare subtype of mucinous adenocarcinoma characterized by gastric differentiation and is unrelated to human papillomavirus (HPV) infection. This report discusses a 40-year-old female who presented with abdominal distension accompanied by increased abdominal circumference. CT of the abdomen and pelvis showed a large 21.0*12.7*26.0 cm mass later diagnosed as GAS combined with squamous cell carcinoma on surgical pathology. Immunohistological staining of GAS was positive for CK7, MUC6, PAX-8 CEA, and P53 (wild type) and negative for CDX2, CK20, ER, PR, P16, and WT1. The proliferative index (Ki-67) was 20%. Immunohistochemical staining of squamous cell carcinoma was positive for P16 and P53 (wild type), and the proliferative index (Ki-67) was 90%. However, the pathogenesis and molecular mechanisms of GAS have not been fully elucidated. As more cases are identified and reported, additional targeted therapies can be developed and tested in these patients.

Keywords:

• cervical cancer
• gastric type
• adenocarcinoma

Ethics Committee

The study protocol was approved to carry out by the Ethics Committee of Yantai Affiliated Hospital of Binzhou Medical University, and institutional approval was not required to publish the case details. Written informed consent was obtained from the patient for the publication of this case report and any accompanying images. The study was performed in accordance with the principles of the Declaration of Helsinki.

Acknowledgment

We thank all the medical care personnel involved in the treatment of this patient, especially Dr. Ping Chu. She was involved in the surgery and treatment.

Disclosure

The authors report no conflicts of interest related to this work.