Abstract
Aim:
To explore the association between the neutrophil-to-platelet ratio (NPR) and futile recanalization (FR) in patients with acute ischemic stroke due to large vascular occlusions after endovascular therapy (EVT).
Methods:
FR after EVT was defined as a poor 90-day prognosis (modified Rankin scale [mRS] score ≥3) despite successful reperfusion (modified thrombolysis in cerebral infarction grade 2b–3). Patients were divided into high NPR (>35; n = 115) and low NPR (≤35; n = 81) groups.
Results:
The FR rate was significantly higher in the high NPR group than low NPR group (81.74 vs 55.56%; p = 0.000). NPR was independently associated with FR (odds ratio: 2.107; 95% CI: 1.017–4.364; p = 0.045).
Conclusion:
High NPR was associated with the risk of FR in patients with acute ischemic stroke due to large vascular occlusions.
Author contributions
BH Li and NW Yu designed the study. BH Li, LR Wang and JH Wang performed the statistical analyses and drafted the manuscript. J Huang, S Yang, B Huang, LJ Jia, S Zhou and FQ Guo screened and extracted data. All authors have made an intellectual contribution to the manuscript and have approved the submission.
Financial disclosure
This study was funded by the Sichuan Natural Science Foundation (grant no. 2023NSFSC0582). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
Competing interests disclosure
The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
Writing disclosure
Medical writing support was provided by Editage (www.editage.com) and was funded by the Sichuan Natural Science Foundation (grant no. 2023NSFSC0582).
Ethical conduct of research
The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.