![Sample our Earth Sciences journals, sign in here to start your access, latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5930/TOC-Subject-Sample-2021-Earth-Sciences.jpg"})
Abstract
Aims: To investigate the effects of Ferrostatin-1 (Fer-1) on improving the prognosis of liver transplant recipients with steatotic liver grafts and regulating gut microbiota in rats. Methods: We obtained steatotic liver grafts and established a liver transplantation model. Recipients were divided into sham, liver transplantation and Fer-1 treatment groups, which were assessed 1 and 7 days after surgery (n = 6). Results & conclusion: Fer-1 promotes recovery of the histological structure and function of steatotic liver grafts and the intestinal tract, and improves inflammatory responses of recipients following liver transplantation. Fer-1 reduces gut microbiota pathogenicity, and lowers iron absorption and improves fat metabolism of recipients, thereby protecting steatotic liver grafts.
Graphical Abstract
Supplementary data
To view the supplementary data that accompany this paper please visit the journal website at: www.tandfonline.com/doi/suppl/10.2217/fmb-2023-0133
Author contributions
HL Song, MS Yuan conceived the study. HL Song and MS Yuan designed the research. YX Wang, XR Tian, WP Zheng, HW Zuo and XR Zhang assisted in mouse experiments. MS Yuan, YX Wang, XR Tian, WP Zheng, HW Zuo and XR Zhang performed the experiments. MS Yuan and WP Zheng analyzed the data. HL Song, WP Zheng supervised the study. MS Yuan wrote the paper. WP Zheng and HL Song contributed to revision. All authors contributed to the article and approved the submitted version.
Acknowledgments
We thank Key Laboratory of Emergency and Care Medicine of Ministry of Health and Tianjin Key Laboratory of Organ Transplantation for allowing this work to progress in their laboratories. The manuscript was edited for proper English language, grammar, punctuation, spelling, and overall style by one or more of the highly qualified native English-speaking editors at ELIXIGEN.
Financial disclosure
The work was supported by the National Natural Science Foundation of China (nos. 82070639, 81670574, 81441022, and 81270528). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
Competing interests disclosure
The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
Writing disclosure
No writing assistance was utilized in the production of this manuscript.
Ethical conduct of research
The authors state that the study was reviewed and approved by the Animal Ethics Committee of Nankai University (ethics no. 2021-SYDWLL-000331) and have followed the principles outlined in the animal experimental investigations.
Open access
This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/