A predictive nomogram developed and validated for gastric cancer patients with triple-negative tumor markers

Abstract

Aim: To predict the prognosis of gastric cancer patients with triple-negative tumor markers. Materials & methods: Prognostic factors of the nomogram were identified through univariate and multivariate Cox regression analyses. Calibration and receiver operating characteristic curves were used to assess accuracy. Decision curve analysis and concordance indexes were utilized to compare the nomogram with the pathological tumor, node, metastasis stage. Results: A nomogram incorporating log odds of positive lymph nodes, tumor size and lymphocyte-to-monocyte ratio was constructed. The calibration and receiver operating characteristic curves (area under the curve >0.85) showed high accuracy in predicting overall survival. The concordance indexes (0.832 vs 0.760; p < 0.001) and decision curve analysis demonstrated that the nomogram was superior to the pathological tumor, node, metastasis stage. Conclusion: A prediction and risk stratification nomogram has been developed and validated for gastric cancer patients with triple-negative tumor markers.

Keywords: :

• gastric cancer
• log odds of positive lymph nodes
• lymphocyte-to-monocyte ratio
• nomogram
• prognosis
• tumor marker

Supplementary data

To view the supplementary data that accompany this paper please visit the journal website at: www.tandfonline.com/doi/suppl/10.2217/fon-2023-0626

Author contributions

Study design: C Huang, Y Xu, P Zhang, Z Luo and G Cen. Data collection: Y Xu, P Zhang, Z Luo, S Zhang and Y Zhang. Manuscript preparation: C Huang and Y Xu. Data analysis: Y Xu, P Zhang, Z Luo and G Cen. All authors contributed to the manuscript and approved the submitted version and are responsible for the content.

Financial disclosure

This study was supported by the National Natural Science Foundation of China (82072662, 82203751), Shanghai Three-Year Action Plan to Promote Clinical Skills and Clinical Innovation in Municipal Hospitals (SHDC2020CR4022), Shanghai Municipal Education Commission – Gaofeng Clinical Medicine Grant Support (the second round, 20191425) and Shanghai Anticancer Association Eyas Project (grant No. SACACY21C08). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Competing interests disclosure

The authors have no competing interests or relevant affiliations with any organization or entity with an interest in or conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending or royalties.

Writing disclosure

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, this study involved the analysis and sharing of anonymized patient data, informed consent was not required.

Open access

This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/