Aspartame-Direct Compression Excipients: Preformulation Stability Screening Using Differential Scanning Calorimetry

Hamed H. El-Shattawy Department of Pharmaceutics, Division of Pharmacy, Faculty of Medicine, Al-Azhar University, Nasr-City, Cairo, Egypt

Garnet E. Peck Department of Industrial and Physical Pharmacy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN, 47907, USA

Dane O. Kildsig Department of Industrial and Physical Pharmacy, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN, 47907, USA

Abstract

Differential scanning calorimetry was used as a screening technique for assessing the compatibility of Aspartame with some of the currently available direct compression excipients. AsDartame was found to be compatible with Avicel PH 101, Avicel PH 105, Elcema F 150, Elcema G 250, Sta-Rx 1500, Cab-O-Sil, Sorbitol, Di-Pac and Brownex Sugar, while incompatible with dicalcium phosphate dihydrate. It appears that stearic acid can be used as a lubricant in formulations containing Aspartame while magnesium stearate cannot.

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Aspartame-Direct Compression Excipients: Preformulation Stability Screening Using Differential Scanning Calorimetry

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Aspartame-Direct Compression Excipients: Preformulation Stability Screening Using Differential Scanning Calorimetry

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