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Abstract
It has been reported that inhaling formaldehyde (FA) causes damage to the central nervous system. However, it is unclear whether FA can disturb the function of the olfactory bulb. Using a microarray, we found that FA inhalation altered the miRNA expression profile. Functional enrichment analysis of the predicted targets of the changed miRNA showed that the enrichment canonical pathways and networks associated with cancer and transcriptional regulation. FA exposure disrupts miRNA expression profiles within the olfactory bulb.
Acknowledgements
We thank Prof. Iain Charles Bruce, and Joseph Grossi, for corrections to the English text and Prof. Jingwei Zhao, Department of Neurobiology, Zhejiang University School of Medicine, for corrections and suggestions to the article.
Declaration of interest
The authors declare that they have no conflict of interests. This work was partly supported by the National Natural Science Foundation of China (81371404).