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Abstract
To clarify the relationship between exposure to nitrogen dioxide (NO2) and mast-cell responses, rats and guinea pigs were exposed to 0, 1.0, 2.0, and 4.0 ppm NO2 for 12 wk. Although lung wet weights were not changed in both rats and guinea pigs, the number of lung cells from 2.0 and 4.0 ppm NO2-exposed rats were significantly decreased compared to that of control. No difference was observed in the number of lung mast cells from rats and guinea pigs exposed to NO2. in lung mast cells from rats, immunoglobulin E (IgE) mediated histamine release was slightly decreased, but A23187-induced histamine release was not changed. On the contrary, in lung mast cells from guinea pigs, IgE-mediated histamine release was increased in a dose-dependent fashion, though no changes in A23187-induced histamine release were observed. These results suggest that different sensitivity for NO2 exposure exists in lung mast cells from rats and guinea pigs.