Toxicologic and Oncogenic Potential of JP-4 Vapor: 90-Day Continuous Inhalation Exposure

Abstract

Male and female Fischer 344 rats, female C57BU6 mice, and male and female beagle dogs were divided into three treatment groups and exposed nearly continuously (23 h/day, 7 days/wk) to IP-4 jet fuel vapor at concentrations of 0, 500, and 1000 mg/m³ for 90 days. At exposure termination, all dogs and one-third of the rodents were euthanized and the remaining animals were held for either a 19- or 21 -mo postexposure tumorigenesis observation period. Pathologic findings in male rats revealed treatment-related renal toxicity consistent with male rat α_2μ-globulin nephropathy. No treatment-related respiratory toxicity was noted in any species. This study did not demonstrate target-organ toxicity or carcinogenesis that could be extrapolated to other species.