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Xenobiotica
the fate of foreign compounds in biological systems
Volume 31, 2001 - Issue 6
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Research Article

Carbamazepine: a 'blind' assessment of CYP-associated metabolism and interactions in human liver-derived in vitro systems

O. Pelkonen University of Oulu, Department of Pharmacology and Toxicology, PO Box 5000, FIN-90014 Oulu, Finland
,
P. Myllynen University of Oulu, Department of Pharmacology and Toxicology, PO Box 5000, FIN-90014 Oulu, Finland
,
P. Taavitsainen University of Oulu, Department of Pharmacology and Toxicology, PO Box 5000, FIN-90014 Oulu, Finland
,
A. R. Boobis Imperial College School of Medicine, Department of Medicine, Section of Clinical Pharmacology, London, UK
,
P. Watts Imperial College School of Medicine, Department of Medicine, Section of Clinical Pharmacology, London, UK
,
B. G. Lake TNO BIBRA International Ltd, Carshalton, UK
,
R. J. Price TNO BIBRA International Ltd, Carshalton, UK
,
A. B. Renwick TNO BIBRA International Ltd, Carshalton, UK
,
M.-J. Gómez-Lechón Unidad Hepatologia Experimental, Centro de Investigacion, Hospital Universitario La Fe. Valencia, Spain
,
J. V. Castell Unidad Hepatologia Experimental, Centro de Investigacion, Hospital Universitario La Fe. Valencia, Spain
,
M. Ingelman-Sundberg Karolinska Institutet, Institute of Environmental Medicine, Division of Molecular Toxicology, Stockholm, Sweden
,
M. Hidestrand Karolinska Institutet, Institute of Environmental Medicine, Division of Molecular Toxicology, Stockholm, Sweden
,
A. Guillouzo Karolinska Institutet, Institute of Environmental Medicine, Division of Molecular Toxicology, Stockholm, Sweden
,
L. Corcos University of Rennes, Faculty of Pharmacy, INSERM U456, Rennes, France
,
P. S. Goldfarb University of Surrey School of Biological Sciences, Guildford, UK
&
D. F. V. Lewis University of Surrey School of Biological Sciences, Guildford, UK
 show all
Pages 321-343 | Published online: 22 Sep 2008

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Maria Rosa, Pierre Bonnaillie & Hugues Chanteux. (2016) Prediction of drug–drug interactions with carbamazepine-10,11-epoxide using a new in vitro assay for epoxide hydrolase inhibition. Xenobiotica 46:12, pages 1076-1084.
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Brian G. Lake & Roger J. Price. (2013) Evaluation of the metabolism and hepatotoxicity of xenobiotics utilizing precision-cut slices. Xenobiotica 43:1, pages 41-53.
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Yogita Ghodke Puranik, Angela K Birnbaum, Susan E Marino, Ghada Ahmed, James C Cloyd, Rory P Remmel, Ilo E Leppik & Jatinder K Lamba. (2013) Association of Carbamazepine Major Metabolism and Transport Pathway Gene Polymorphisms and Pharmacokinetics in Patients with Epilepsy. Pharmacogenomics 14:1, pages 35-45.
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Gianpiero L Cavalleri, Mark McCormack, Saud Alhusaini, Elijah Chaila & Norman Delanty. (2011) Pharmacogenomics and Epilepsy: The Road Ahead. Pharmacogenomics 12:10, pages 1429-1447.
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Sandeep Grover, Mandaville Gourie-Devi, Ruchi Baghel, Sangeeta Sharma, Kiran Bala, Meena Gupta, Krishnamoorthy Narayanasamy, Binuja Varma, Meenal Gupta, Kavita Kaur, Puneet Talwar, Harpreet Kaur, Sudheer Giddaluru, Abhay Sharma, Samir K Brahmachari, Indian Genome Variation Consortium & Ritushree Kukreti. (2010) Genetic Profile of Patients with Epilepsy on First-Line Antiepileptic Drugs and Potential Directions for Personalized Treatment. Pharmacogenomics 11:7, pages 927-941.
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Shu-Feng Zhou, Bo Wang, Li-Ping Yang & Jun-Ping Liu. (2010) Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2. Drug Metabolism Reviews 42:2, pages 268-354.
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María José Gómez-Lechón, José V Castell & María Teresa Donato. (2008) An update on metabolism studies using human hepatocytes in primary culture. Expert Opinion on Drug Metabolism & Toxicology 4:7, pages 837-854.
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K. Venkatakrishnan, R. S. Obach & A. Rostami-Hodjegan. (2007) Mechanism-based inactivation of human cytochrome P450 enzymes: strategies for diagnosis and drug–drug interaction risk assessment. Xenobiotica 37:10-11, pages 1225-1256.
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Kentaro Ueda, Takateru Ishitsu, Takayuki Seo, Nao Ueda, Tsukasa Murata, Masaharu Hori & Kazuko Nakagawa. (2007) Glutathione S-Transferase M1 Null Genotype as a Risk Factor for Carbamazepine-Induced Mild Hepatotoxicity. Pharmacogenomics 8:5, pages 435-442.
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Juergen Friedrich, Reinhard Ebner & Leoni A. Kunz-Schughart. (2007) Experimental anti-tumor therapy in 3-D: Spheroids – old hat or new challenge?. International Journal of Radiation Biology 83:11-12, pages 849-871.
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Olavi Pelkonen & Hannu Raunio. (2005) In vitro screening of drug metabolism during drug development: can we trust the predictions?. Expert Opinion on Drug Metabolism & Toxicology 1:1, pages 49-59.
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Shufeng Zhou, Eli Chan, Wei Duan, Min Huang & Yu-Zong Chen. (2005) Drug Bioactivation Covalent Binding to Target Proteins and Toxicity Relevance. Drug Metabolism Reviews 37:1, pages 41-213.
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Shufeng Zhou, Yihuai Gao, Wenqi Jiang, Min Huang, Anlong Xu & James W. Paxton. (2003) Interactions of Herbs with Cytochrome P450. Drug Metabolism Reviews 35:1, pages 35-98.
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F Lakehal, C.J Wurden, T.F Kalhorn & R.H Levy. (2002) Carbamazepine and oxcarbazepine decrease phenytoin metabolism through inhibition of CYP2C19. Epilepsy Research 52:2, pages 79-83.
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