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Journal of Asthma Volume 45, 2008 - Issue 8
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ORIGINAL ARTICLE

Deterioration in Asthma Control When Subjects Receiving Fluticasone Propionate/Salmeterol 100/50 mcg Diskus are “Stepped-Down”

Steven M. Koenig University of Virginia, Charlottesville, Virginia, USA
, MD,
Nancy Ostrom Allergy & Asthma Medical Group and Research Center, APC, San Diego, California, USA
, MD,
David Pearlman Colorado Allergy and Asthma Centers, PC, Denver, Colorado, USA
, MD,
Kelli Waitkus-Edwards GlaxoSmithKline, Research Triangle Park, North Carolina, USA
, PhD,
Steven Yancey GlaxoSmithKline, Research Triangle Park, North Carolina, USA
, MS,
Barbara A. Prillaman GlaxoSmithKline, Research Triangle Park, North Carolina, USA
, MS, MA &
Paul Dorinsky GlaxoSmithKline, Research Triangle Park, North Carolina, USA
, MD show all
Pages 681-687 | Published online: 02 Jul 2009

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Marjorie Slankard, Mary Ann Michelis, Mahesh Mansukhani, Barbara McGoey, Amy Paige, Howard Andrews, David Lederer, Stephen Canfield & Emily DiMango. (2016) Impact of the Arg 16 allele of the B2AR gene on the effect of withdrawal of LABA in patients with moderate to severe asthma. Journal of Asthma 53:8, pages 783-789.
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Carlos A. Camargo$suffix/text()$suffix/text(), Louis-Philippe Boulet, E. Rand Sutherland, William W. Busse, Steven W. Yancey, Amanda H. Emmett, Hector G. Ortega & Thomas J. Ferro. (2010) Body Mass Index and Response to Asthma Therapy: Fluticasone Propionate/Salmeterol versus Montelukast. Journal of Asthma 47:1, pages 76-82.
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Karina Mayoral, Catalina Lizano-Barrantes, Víctor Zamora, Angels Pont, Carme Miret, Cristina Barrufet, M. Araceli Caballero-Rabasco, Manuel Praena-Crespo, Alberto Bercedo, Laura Valdesoiro-Navarrete, Maria Teresa Guerra, Yolanda Pardo, Mª José Martínez Zapata, Olatz Garin & Montse Ferrer. (2023) Montelukast in paediatric asthma and allergic rhinitis: a systematic review and meta-analysis. European Respiratory Review 32:170, pages 230124.
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Bruno SPOSATO, Elisa PETRUCCI, Gianluca L. LACERENZA, Claudio MICHELETTO, Andrea MONTAGNANI, Massimo ALESSANDRI, Alberto CRESTI, Andrea SERAFINI, Fabio LENA, Raffaele SCALA, Paola ROGLIANI, Antonio PERRELLA & Marco SCALESE. (2023) Sex differences in excessive oral corticosteroid exposure in poor adherent adult asthmatics overusing short-acting β-2 agonists. Minerva Medica 114:5.
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C. Raherison-Semjen, L. Guilleminault, I. Billiart, C. Chenivesse, A. De Oliveira, A. Izadifar, A. Lorenzo, C. Nocent, J.P. Oster, M. Padovani, T. Perez, M. Russier, M. Steinecker & A. Didier. (2021) Mise à jour des recommandations (2021) pour la prise en charge et le suivi des patients asthmatiques adultes sous l’égide de la Société de pneumologie de langue française (SPLF) et de la Société pédiatrique de pneumologie et allergologie (SP2A). Version longue. Revue des Maladies Respiratoires 38:10, pages 1048-1083.
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Sae-Hoon Kim, Taehoon Lee, An-Soo Jang, Chan Sun Park, Jae-Woo Jung, Min-Hye Kim, Jae-Woo Kwon, Ji-Yong Moon, Min-Suk Yang, Jaechun Lee, Jeong-Hee Choi, Yoo Seob Shin, Hee-Kyoo Kim, Sujeong Kim, Joo-Hee Kim, Suh-Young Lee, Young-Hee Nam, Sang-Hoon Kim, Tae-Bum Kim, Woo-Jung Song, Hyouk-Soo Kwon, You Sook, Bomi Seo, Jung-Hyun Kim, Byoung-Whui Choi, Young-Joo Cho, So Young Park, Sun-Young Yoon, Hyun Jung Jin, So-Young Park, Hye-Kyung Park, Gyu Young Hur & Sang Ha Kim. (2021) Pragmatic Randomized Controlled Trial for Stepping Down Asthma Controller Treatment in Patients Controlled with Low-Dose Inhaled Corticosteroid and Long-Acting β2-Agonist: Step-Down of Intervention and Grade in Moderate Asthma Study. The Journal of Allergy and Clinical Immunology: In Practice 9:10, pages 3638-3646.e3.
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Cindy L.J. Weinstein, Nicholas Ryan, Xiaoli Zhang, Tulin Shekar, Davis Gates, Stephen J. Lane, Ioana Agache, Robert A. Nathan, Veerle Van de Velde, Melanie Jones & Carmen Antonio. (2020) Serious Asthma Outcomes and Asthma Exacerbations with Maintenance on Inhaled Corticosteroid (Mometasone Furoate)/Long-Acting Beta Agonist (Formoterol) Combination Compared to Step Down to Mometasone Monotherapy. The Journal of Allergy and Clinical Immunology: In Practice 8:5, pages 1634-1644.e1.
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Bradley E. Chipps, Leonard B. Bacharier, Kevin R. Murphy, David Lang, Judith R. Farrar, Matthew Rank, John Oppenheimer & Robert S. Zeiger. (2019) The Asthma Controller Step-down Yardstick. Annals of Allergy, Asthma & Immunology 122:3, pages 241-262.e4.
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Omar S. Usmani, Anu Kemppinen, Elizabeth Gardener, Vicky Thomas, Priyanka Raju Konduru, Christina Callan, Andrew McLoughlin, Vanessa Woodhead, Adam Brady, Elizabeth F. Juniper, Peter J. Barnes & David Price. (2017) A Randomized Pragmatic Trial of Changing to and Stepping Down Fluticasone/Formoterol in Asthma. The Journal of Allergy and Clinical Immunology: In Practice 5:5, pages 1378-1387.e5.
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Mitsuru Adachi, Caroline Goldfrad, Loretta Jacques & Yoshie Nishimura. (2016) Efficacy and safety comparison: Fluticasone furoate and fluticasone propionate, after step down from fluticasone furoate/vilanterol in Japanese patients with well-controlled asthma, a randomized trial. Respiratory Medicine 120, pages 78-86.
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Heikki O. Koskela, Minna K. Purokivi & Jouko Kokkarinen. (2016) Stepping down from combination asthma therapy: The predictors of outcome. Respiratory Medicine 117, pages 109-115.
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Shaleen Ahmad, Kayleigh M Kew & Rebecca Normansell. (2015) Stopping long-acting beta 2 -agonists (LABA) for adults with asthma well controlled by LABA and inhaled corticosteroids . Cochrane Database of Systematic Reviews.
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Kayleigh M Kew, Sean Beggs & Shaleen Ahmad. (2015) Stopping long-acting beta2-agonists (LABA) for children with asthma well controlled on LABA and inhaled corticosteroids. Cochrane Database of Systematic Reviews 2017:12.
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John B. Hagan & Matthew A. Rank. (2015) Assessing the Risks and Benefits of Step-Down Asthma Care: A Case-Based Approach. Current Allergy and Asthma Reports 15:3.
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Alberto Papi, Gabriele Nicolini, Nunzio Crimi, Leonardo Fabbri, Dario Olivieri, Andrea Rossi & Pierluigi Paggiaro. (2012) Step-down from high dose fixed combination therapy in asthma patients: a randomized controlled trial. Respiratory Research 13:1, pages 54.
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