Citations (27)
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Read on this site (5)
Tomoya Yamada, Samuel M. Cohen & Brian G. Lake. (2021) Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR). Critical Reviews in Toxicology 51:5, pages 373-394.
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Adam Barsouk, Krishna Chaitanya Thandra, Kalyan Saginala, Prashanth Rawla & Alexander Barsouk. (2020) Chemical Risk Factors of Primary Liver Cancer: An Update. Hepatic Medicine: Evidence and Research 12, pages 179-188.
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Corinne Haines, Lynsey R. Chatham, Audrey Vardy, Clifford R. Elcombe, John R. Foster & Brian G. Lake. (2019) Comparison of the hepatic and thyroid gland effects of sodium phenobarbital and pregnenolone-16α-carbonitrile in wild-type and constitutive androstane receptor (CAR)/pregnane X receptor (PXR) knockout rats. Xenobiotica 49:2, pages 227-238.
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Paolo Boffetta & Vimi Desai. (2018) Exposure to permethrin and cancer risk: a systematic review. Critical Reviews in Toxicology 48:6, pages 433-442.
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Clifford R. Elcombe, Richard C. Peffer, Douglas C. Wolf, Jason Bailey, Remi Bars, David Bell, Russell C. Cattley, Stephen S. Ferguson, David Geter, Amber Goetz, Jay I. Goodman, Susan Hester, Abigail Jacobs, Curtis J. Omiecinski, Rita Schoeny, Wen Xie & Brian G. Lake. (2014) Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator. Critical Reviews in Toxicology 44:1, pages 64-82.
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Articles from other publishers (22)
Tomoya Yamada. (2021) Application of humanized mice to toxicology studies: Evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR). Journal of Toxicologic Pathology 34:4, pages 283-297.
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Tomoya Yamada, Ayako Ohara, Naoya Ozawa, Keiko Maeda, Miwa Kondo, Yu Okuda, Jun Abe, Samuel M Cohen & Brian G Lake. (2020) Comparison of the Hepatic Effects of Phenobarbital in Chimeric Mice Containing Either Rat or Human Hepatocytes With Humanized Constitutive Androstane Receptor and Pregnane X Receptor Mice. Toxicological Sciences 177:2, pages 362-376.
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Brian G. Lake, Roger J. Price, Mary P. Scott, Lynsey R. Chatham, Audrey Vardy & Thomas G. Osimitz. (2020) Piperonyl butoxide: Mode of action analysis for mouse liver tumour formation and human relevance. Toxicology 439, pages 152465.
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Manuela Goettel, Ivana Fegert, Naveed Honarvar, Audrey Vardy, Corinne Haines, Lynsey R. Chatham & Brian G. Lake. (2020) Comparative studies on the effects of sodium phenobarbital and two other constitutive androstane receptor (CAR) activators on induction of cytochrome P450 enzymes and replicative DNA synthesis in cultured hepatocytes from wild type and CAR knockout rats. Toxicology 433-434, pages 152394.
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Christiane Wiemann, Manuela Goettel, Audrey Vardy, Barbara M. Elcombe, Clifford R. Elcombe, Lynsey R. Chatham, Hongbing Wang, Linhao Li, Roland Buesen, Naveed Honarvar, Silke Treumann, Heike Marxfeld, Sibylle Groeters & Brian G. Lake. (2019) Metazachlor: Mode of action analysis for rat liver tumour formation and human relevance. Toxicology 426, pages 152282.
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Miwa Kondo, Kaori Miyata, Hirohisa Nagahori, Kayo Sumida, Thomas G Osimitz, Samuel M Cohen, Brian G Lake & Tomoya Yamada. (2019) Involvement of Peroxisome Proliferator-Activated Receptor-Alpha in Liver Tumor Production by Permethrin in the Female Mouse. Toxicological Sciences 168:2, pages 572-596.
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Brian G. Lake. (2018) Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators. Toxicology Research 7:4, pages 697-717.
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Tomoya Yamada. (2018) Case examples of an evaluation of the human relevance of the pyrethroids/pyrethrins-induced liver tumours in rodents based on the mode of action. Toxicology Research 7:4, pages 681-696.
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Corinne Haines, Lynsey R. Chatham, Audrey Vardy, Clifford R. Elcombe, John R. Foster & Brian G. Lake. (2018) Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16α-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats. Toxicology 400-401, pages 20-27.
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Yu Okuda, Masahiko Kushida, Kayo Sumida, Hirohisa Nagahori, Yoshimasa Nakamura, Hashihiro Higuchi, Satoshi Kawamura, Brian G. Lake, Samuel M. Cohen & Tomoya Yamada. (2017) Editor’s Highlight: Mode of Action Analysis for Rat Hepatocellular Tumors Produced by the Synthetic Pyrethroid Momfluorothrin: Evidence for Activation of the Constitutive Androstane Receptor and Mitogenicity in Rat Hepatocytes. Toxicological Sciences 158:2, pages 412-430.
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Golla Madhubabu & Suresh Yenugu. (2017) Allethrin toxicity causes reproductive dysfunction in male rats. Environmental Toxicology 32:6, pages 1701-1710.
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Caterina Ledda, Carla Loreto, Christian Zammit, Andrea Marconi, Lucrezia Fago, Serena Matera, Valentina Costanzo, Giovanni Fuccio Sanzà, Stefano Palmucci, Margherita Ferrante, Chiara Costa, Concettina Fenga, Antonio Biondi, Cristoforo Pomara & Venerando Rapisarda. (2017) Non-infective occupational risk factors for hepatocellular carcinoma: A review. Molecular Medicine Reports 15:2, pages 511-533.
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Yu Okuda, Masahiko KushidaHiroko KikumotoYoshimasa Nakamura, Hashihiro HiguchiSatoshi KawamuraSamuel M. Cohen, Brian G. Lake & Tomoya Yamada. (2017) Evaluation of the human relevance of the constitutive androstane receptor-mediated mode of action for rat hepatocellular tumor formation by the synthetic pyrethroid momfluorothrin. The Journal of Toxicological Sciences 42:6, pages 773-788.
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Delfina M. Romero, Bruno G. Berardino, Marcelo J. Wolansky & Mónica L. Kotler. (2017) From the Cover: Vulnerability of C6 Astrocytoma Cells After Single-Compound and Joint Exposure to Type I and Type II Pyrethroid Insecticides. Toxicological Sciences 155:1, pages 196-212.
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Ayako Ohara, Yasuhiko Takahashi, Miwa Kondo, Yu Okuda, Shuji Takeda, Masahiko Kushida, Kentaro Kobayashi, Kayo Sumida & Tomoya Yamada. (2017) Candidate genes responsible for early key events of phenobarbital-promoted mouse hepatocellular tumorigenesis based on differentiation of regulating genes between wild type mice and humanized chimeric mice. Toxicology Research 6:6, pages 795-813.
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Masahiko Kushida, Tomoya Yamada & Yasuyoshi Okuno. 2016. Thresholds of Genotoxic Carcinogens. Thresholds of Genotoxic Carcinogens
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Brian G Lake, Roger J Price & Thomas G Osimitz. (2015) Mode of action analysis for pesticide-induced rodent liver tumours involving activation of the constitutive androstane receptor: relevance to human cancer risk. Pest Management Science 71:6, pages 829-834.
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Yohei Sakamoto, Kaoru Inoue, Miwa Takahashi, Yoshikazu Taketa, Yukio Kodama, Kiyomitsu Nemoto, Masakuni Degawa, Toshie Gamou, Shogo Ozawa, Akiyoshi Nishikawa & Midori Yoshida. (2013) Different Pathways of Constitutive Androstane Receptor–mediated Liver Hypertrophy and Hepatocarcinogenesis in Mice Treated with Piperonyl Butoxide or Decabromodiphenyl Ether. Toxicologic Pathology 41:8, pages 1078-1092.
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Mario Uccello, Giulia Malaguarnera, Thea Corriere, Antonio Biondi, Francesco Basile & Mariano Malaguarnera. (2012) Risk of Hepatocellular Carcinoma in Workers Exposed to Chemicals. Hepatitis Monthly 12:10.
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Renee M. Zaya, Zakariya Amini, Ashley S. Whitaker, Steven L. Kohler & Charles F. Ide. (2011) Atrazine exposure affects growth, body condition and liver health in Xenopus laevis tadpoles. Aquatic Toxicology 104:3-4, pages 243-253.
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Ryozo Tsuji, Tomoya Yamada & Satoshi Kawamura. 2012. Pyrethroids. Pyrethroids
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