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Journal of Drug Targeting Volume 15, 2007 - Issue 3
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Research Article

Synthesis and in vitro evaluation of N-nicotinoylglycyl-2-(5-fluorouracil-1-yl)-d,l-glycine as a colon-specific prodrug of 5-fluorouracil

Jeoungsoo Lee Bioengineering Department, Clemson University, Clemson, SC29634, USA
,
Joohyun Rho Department of Medicinal Chemistry, College of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan, 609-735, South Korea
,
Youngwook Yang Department of Medicinal Chemistry, College of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan, 609-735, South Korea
,
Hyesik Kong Department of Medicinal Chemistry, College of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan, 609-735, South Korea
,
Yunjin Jung Department of Biomedicinal Chemistry, College of Pharmacy, Pusan National University, Busan, 609-735, South Korea
&
Youngmi Kim Department of Medicinal Chemistry, College of Pharmacy, Research Institute for Drug Development, Pusan National University, Busan, 609-735, South Korea
Pages 199-205 | Received 18 Aug 2006, Accepted 04 Jan 2007, Published online: 08 Oct 2008

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Yunjin Jung & Young Mi Kim. (2010) What should be considered on design of a colon-specific prodrug?. Expert Opinion on Drug Delivery 7:2, pages 245-258.
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Articles from other publishers (6)

Hyesik Kong, Jun-ke Song, Venkata Mahidhar Yenugonda, Li Zhang, Tian Shuo, Amrita K. Cheema, Yali Kong, Guan-hua Du & Milton L. Brown. (2015) Preclinical Studies of the Potent and Selective Nicotinic α4β2 Receptor Ligand VMY-2-95. Molecular Pharmaceutics 12:2, pages 393-402.
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Zhikui Dong, Wenyi Zheng, Zaiyang Xu & Zongning Yin. (2013) Improved stability and tumor targeting of 5-fluorouracil by conjugation with hyaluronan. Journal of Applied Polymer Science 130:2, pages 927-932.
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Hye-Sik Kong, Shuo Tian, Yali Kong, Guanhua Du, Li Zhang, Mira Jung, Anatoly Dritschilo & Milton L. Brown. (2012) Preclinical Studies of YK-4-272, an Inhibitor of Class II Histone Deacetylases by Disruption of Nucleocytoplasmic Shuttling. Pharmaceutical Research 29:12, pages 3373-3383.
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Yikai Zhang, Hanyu Zhong, Tiantian Wang, Dongping Geng, Mingfeng Zhang & Ke Li. (2012) Synthesis of novel 2, 5-dihydrofuran derivatives and evaluation of their anticancer activity. European Journal of Medicinal Chemistry 48, pages 69-80.
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Konstanty Wierzba, Makoto Muroi & Hiroyuki Osada. (2011) Proteomics accelerating the identification of the target molecule of bioactive small molecules. Current Opinion in Chemical Biology 15:1, pages 57-65.
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Duksoo Kim, Sungchae Hong, Sunhwa Jung, Yunjin Jung & Young Mi Kim. (2009) Synthesis and Evaluation of N-Nicotinoyl-2-{2-(2-Methyl-5-Nitroimidazol-1-yl)Ethyloxy}-D,L-Glycine as a Colon-Specific Prodrug of Metronidazole. Journal of Pharmaceutical Sciences 98:11, pages 4161-4169.
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