644
Views
44
CrossRef citations to date
0
Altmetric
Review

Human studies with microneedles for evaluation of their efficacy and safety

&
Pages 235-245 | Received 13 Oct 2017, Accepted 23 Nov 2017, Published online: 30 Nov 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Thuy Trang Nguyen, Thi Thuy Dung Nguyen, Nguyen-Minh-An Tran, Huy Truong Nguyen & Giau Van Vo. (2022) Microneedles enable the development of skin-targeted vaccines against coronaviruses and influenza viruses. Pharmaceutical Development and Technology 27:1, pages 83-94.
Read now
Thuy Trang Nguyen, Yujeong Oh, Yunseo Kim, Yura Shin, Seung-Ki Baek & Jung-Hwan Park. (2021) Progress in microneedle array patch (MAP) for vaccine delivery. Human Vaccines & Immunotherapeutics 17:1, pages 316-327.
Read now
Jacob T. Beaver, Lisa K. Mills, Dominika Swieboda, Nadia Lelutiu, Edward S. Esser, Olivia Q. Antao, Eugenia Scountzou, Dahnide T. Williams, Nikolaos Papaioannou, Elizabeth Q. Littauer, Andrey Romanyuk, Richard W. Compans, Mark R. Prausnitz & Ioanna Skountzou. (2020) Cutaneous vaccination ameliorates Zika virus-induced neuro-ocular pathology via reduction of anti-ganglioside antibodies. Human Vaccines & Immunotherapeutics 16:9, pages 2072-2091.
Read now

Articles from other publishers (41)

Zhi Wei Luo, Zhi Zhong Peng, Xiao Ping Cao, Meng Jia Chen & Xue Qiu You. (2023) Dissolvable microneedle particles for enhanced topical drug delivery. Journal of Drug Delivery Science and Technology, pages 105209.
Crossref
Jiaqi Liu, Hualei Xu, Haiyan Liang, Jiachan Zhang, Huanxiang Yuan, Dan Zhao & Changtao Wang. (2023) An antioxidative, green and safe nanofibers-based film containing pullulan, sodium hyaluronate and Ganoderma lucidum fermentation for enhanced skincare. International Journal of Biological Macromolecules 253, pages 127047.
Crossref
Remmi Danae Baker-Sediako, Benjamin Richter, Matthias Blaicher, Michael Thiel & Martin Hermatschweiler. (2023) Industrial perspectives for personalized microneedles. Beilstein Journal of Nanotechnology 14, pages 857-864.
Crossref
Ramsha Khalid, Syed Mahmood, Zarif Mohamed Sofian, Ayah R. Hilles, Najihah Mohd Hashim & Yi Ge. (2023) Microneedles and Their Application in Transdermal Delivery of Antihypertensive Drugs—A Review. Pharmaceutics 15:8, pages 2029.
Crossref
Tatsuro Amano, Naoto Fujii, Ying-Shu Quan, Glen P. Kenny, Narihiko Kondo, Hirofumi Yamashita & Yoshimitsu Inoue. (2023) In vivo assessments of microneedle arrays and iontophoresis of pilocarpine in human palmar sweating. Journal of Controlled Release 358, pages 161-170.
Crossref
Jai Hee Bae, Heeyeon Kim, Hyungrye Noh, Donghwi Jang, Joonho Shim, Se Jin Oh, Ji Hye Park & Jong Hee Lee. (2023) Clinical Benefit and Safety of Microneedle Patches Composed of Magnesium: A Pilot Study in Acne Patients. Dermatologic Therapy 2023, pages 1-8.
Crossref
Haibin Zheng, Xuankun Xie, Haocong Ling, Xintong You, Siyu Liang, Rurong Lin, Renjie Qiu & Honghao Hou. (2023) Transdermal drug delivery via microneedles for musculoskeletal systems . Journal of Materials Chemistry B.
Crossref
Vineet Kumar Rai, Ivy Saha, Mahboob Alam, Kumar Nishchaya, Goutam Ghosh & Goutam Rath. (2023) Microneedle arrays for cutaneous and transcutaneous drug delivery, disease diagnosis, and cosmetic aid. Journal of Drug Delivery Science and Technology 79, pages 104058.
Crossref
Donghwi Jang, Joonho Shim, Dong Min Shin, Hyungrye Noh, Se Jin Oh, Ji‐Hye Park & Jong Hee Lee. (2022) Magnesium microneedle patches for under‐eye wrinkles. Dermatologic Therapy 35:9.
Crossref
Yushi Yi, Hisanao Komine & Tsuyoshi Furushima. (2022) Effect of forming conditions on microstructure and room-temperature mechanical characterization of Zn–22Al superplastic microtubes fabricated by direct extrusion. Materials Science and Engineering: A 844, pages 143160.
Crossref
Ihab Mansoor, Heba A. Eassa, Kamilia H. A. Mohammed, Marwa A. Abd El-Fattah, Marwa H. Abdo, Eman Rashad, Hadeer A. Eassa, Asmaa Saleh, Omnya M. Amin, Mohamed Ismail Nounou & Ola Ghoneim. (2022) Microneedle-Based Vaccine Delivery: Review of an Emerging Technology. AAPS PharmSciTech 23:4.
Crossref
Prateek Ranjan Yadav, Lewis James Dobson, Sudip K. Pattanayek & Diganta Bhusan Das. (2022) Swellable microneedles based transdermal drug delivery: Mathematical model development and numerical experiments. Chemical Engineering Science 247, pages 117005.
Crossref
Thuy Trang Nguyen, Thi Thuy Dung Nguyen, Nguyen-Minh-An Tran & Giau Van Vo. (2022) Advances of microneedles in hormone delivery. Biomedicine & Pharmacotherapy 145, pages 112393.
Crossref
Yiqun Liu, Qi Yu, Xiaojin Luo, Li Yang & Yue Cui. (2021) Continuous monitoring of diabetes with an integrated microneedle biosensing device through 3D printing. Microsystems & Nanoengineering 7:1.
Crossref
Yasmine Gomaa, Chandana Kolluru, Mikolaj Milewski, Dinah Lee, Jingtao Zhang, Robert Saklatvala & Mark R. Prausnitz. (2021) Development of a thermostable oxytocin microneedle patch. Journal of Controlled Release 337, pages 81-89.
Crossref
Song Li, Kelsey Hart, Natalie Norton, Clare A. Ryan, Lokesh Guglani & Mark R. Prausnitz. (2021) Administration of pilocarpine by microneedle patch as a novel method for cystic fibrosis sweat testing. Bioengineering & Translational Medicine 6:3.
Crossref
Nadine G. Rouphael, Lilin Lai, Sonia Tandon, Michele Paine McCullough, Yunchuan Kong, Sarah Kabbani, Muktha S. Natrajan, Yongxian Xu, Yerun Zhu, Dongli Wang, Jesse O’Shea, Amy Sherman, Tianwei Yu, Sebastien Henry, Devin McAllister, Daniel Stadlbauer, Surender Khurana, Hana Golding, Florian Krammer, Mark J. Mulligan & Mark R. Prausnitz. (2021) Immunologic mechanisms of seasonal influenza vaccination administered by microneedle patch from a randomized phase I trial. npj Vaccines 6:1.
Crossref
Principia Dardano, Mario Battisti, Selene De Martino, Ilaria Rea, Bruno Miranda, Luigi Nicolais & Luca De Stefano. 2021. Biosensors - Current and Novel Strategies for Biosensing. Biosensors - Current and Novel Strategies for Biosensing.
Ester Caffarel-Salvador, Soyoung Kim, Vance Soares, Ryan Yu TianSarah R. Stern, Daniel Minahan, Raissa Yona, Xiaoya LuFauziah R. Zakaria, Joy Collins, Jacob WainerJessica WongRebecca McManus, Siddartha TamangShane McDonnellKeiko Ishida, Alison Hayward, Xiewen LiuFrantišek Hubálek, Johannes Fels, Andreas VeggeMorten Revsgaard Frederiksen, Ulrik Rahbek, Tadayuki YoshitakeJames Fujimoto, Niclas Roxhed, Robert Langer & Giovanni Traverso. (2021) A microneedle platform for buccal macromolecule delivery. Science Advances 7:4.
Crossref
Rohan S.J. Ingrole, Erkan Azizoglu, Maria Dul, James C. Birchall, Harvinder S. Gill & Mark R. Prausnitz. (2021) Trends of microneedle technology in the scientific literature, patents, clinical trials and internet activity. Biomaterials 267, pages 120491.
Crossref
Motia Azmana, Syed Mahmood, Ayah Rebhi Hilles, Uttam Kumar Mandal, Khater Ahmed Saeed Al-Japairai & Subashini Raman. (2020) Transdermal drug delivery system through polymeric microneedle: A recent update. Journal of Drug Delivery Science and Technology 60, pages 101877.
Crossref
Rezvan Jamaledin, Pooyan Makvandi, Cynthia K. Y. Yiu, Tarun Agarwal, Raffaele Vecchione, Wujin Sun, Tapas Kumar Maiti, Franklin R. Tay & Paolo Antonio Netti. (2020) Engineered Microneedle Patches for Controlled Release of Active Compounds: Recent Advances in Release Profile Tuning. Advanced Therapeutics 3:12.
Crossref
Seung-Yeon Jeong, Jung-Hwan Park, Ye-Seul Lee, Youn-Sub Kim, Ji-Yeun Park & Song-Yi Kim. (2020) The Current Status of Clinical Research Involving Microneedles: A Systematic Review. Pharmaceutics 12:11, pages 1113.
Crossref
Thuy Trang Nguyen, Thi Thuy Dung Nguyen, Qui Thanh Hoai Ta & Van Giau Vo. (2020) Advances in non and minimal-invasive transcutaneous delivery of immunotherapy for cancer treatment. Biomedicine & Pharmacotherapy 131, pages 110753.
Crossref
Sara L. Silvestre, Diana Araújo, Ana C. Marques, Carolina Pires, Mariana Matos, Vítor Alves, Rodrigo Martins, Filomena Freitas, Maria A. M. Reis & Elvira Fortunato. (2020) Microneedle Arrays of Polyhydroxyalkanoate by Laser-Based Micromolding Technique. ACS Applied Bio Materials 3:9, pages 5856-5864.
Crossref
Hye-Rin Jeong, Joon-Yong Bae, Jee-Hyun Park, Seung-Ki Baek, Gayeong Kim, Man-Seong Park & Jung-Hwan Park. (2020) Preclinical study of influenza bivalent vaccine delivered with a two compartmental microneedle array. Journal of Controlled Release 324, pages 280-288.
Crossref
In-Jeong Choi, Woonsung Na, Aram Kang, Myun-Hwan Ahn, Minjoo Yeom, Hyung-Ouk Kim, Jong-Woo Lim, Seong-O Choi, Seung-Ki Baek, Daesub Song & Jung-Hwan Park. (2020) Patchless administration of canine influenza vaccine on dog’s ear using insertion-responsive microneedles (IRMN) without removal of hair and its in vivo efficacy evaluation. European Journal of Pharmaceutics and Biopharmaceutics 153, pages 150-157.
Crossref
Hye-Rin Jeong, Hyesun Jun, Hye-Ran Cha, Jae Lee & Jung-Hwan Park. (2020) Safe Coated Microneedles with Reduced Puncture Occurrence after Administration. Micromachines 11:8, pages 710.
Crossref
Mark R Prausnitz, James L Goodson, Paul A Rota & Walter A Orenstein. (2020) A microneedle patch for measles and rubella vaccination: a game changer for achieving elimination. Current Opinion in Virology 41, pages 68-76.
Crossref
Hao Chang, Mengjia Zheng, Sharon Wan Ting Chew & Chenjie Xu. (2020) Advances in the Formulations of Microneedles for Manifold Biomedical Applications. Advanced Materials Technologies 5:4.
Crossref
Andrew R. Tadros, Andrey Romanyuk, Ian C. Miller, Andrea Santiago, Richard K. Noel, Laura O’Farrell, Gabriel A. Kwong & Mark R. Prausnitz. (2020) STAR particles for enhanced topical drug and vaccine delivery. Nature Medicine 26:3, pages 341-347.
Crossref
Doo Hee Shim, Thuy Trang Nguyen, Pil-gu Park, Min Jung Kim, Byung-wook Park, Hye-Rin Jeong, Dae-Sung Kim, Hyun Woo Joo, Seong-O Choi, Jung-Hwan Park & Jae Myun Lee. (2019) Development of Botulinum Toxin A-Coated Microneedles for Treating Palmar Hyperhidrosis. Molecular Pharmaceutics 16:12, pages 4913-4919.
Crossref
Wei Li, Jie TangRichard N. Terry, Song Li, Aurelie Brunie, Rebecca L. Callahan, Richard K. Noel, Carlos A. RodríguezSteven P. Schwendeman & Mark R. Prausnitz. (2019) Long-acting reversible contraception by effervescent microneedle patch. Science Advances 5:11.
Crossref
Akhilesh Kumar Shakya, Rohan S.J. Ingrole, Gaurav Joshi, Md Jasim Uddin, Sara Anvari, Carla M. Davis & Harvinder Singh Gill. (2019) Microneedles coated with peanut allergen enable desensitization of peanut sensitized mice. Journal of Controlled Release 314, pages 38-47.
Crossref
Rohan S.J. Ingrole & Harvinder Singh Gill. (2019) Microneedle Coating Methods: A Review with a Perspective. Journal of Pharmacology and Experimental Therapeutics 370:3, pages 555-569.
Crossref
John Havens Cary, Becky S. Li & Howard I. Maibach. (2019) Dermatotoxicology of microneedles (MNs) in man. Biomedical Microdevices 21:3.
Crossref
Principia Dardano, Mario Battisti, Ilaria Rea, Luigia Serpico, Monica Terracciano, Aniello Cammarano, Luigi Nicolais & Luca De Stefano. (2019) Polymeric Microneedle Arrays: Versatile Tools for an Innovative Approach to Drug Administration. Advanced Therapeutics 2:8.
Crossref
Chandana Kolluru, Rohit Gupta, Qisheng Jiang, Mikayla Williams, Hamed Gholami Derami, Sisi Cao, Richard K. Noel, Srikanth Singamaneni & Mark R. Prausnitz. (2019) Plasmonic Paper Microneedle Patch for On-Patch Detection of Molecules in Dermal Interstitial Fluid. ACS Sensors 4:6, pages 1569-1576.
Crossref
Heather A.E. Benson, Jeffrey E. Grice, Yousuf Mohammed, Sarika Namjoshi & Michael S. Roberts. (2019) Topical and Transdermal Drug Delivery: From Simple Potions to Smart Technologies. Current Drug Delivery 16:5, pages 444-460.
Crossref
Chandana Kolluru, Mikayla Williams, Jeremy Chae & Mark R. Prausnitz. (2019) Recruitment and Collection of Dermal Interstitial Fluid Using a Microneedle Patch. Advanced Healthcare Materials 8:3.
Crossref
YUSHI YI & Tsuyoshi Furushima. (2021) Effect of Forming Conditions on Microstructure and Room-Temperature Mechanical Characterization of Zn-22al Superplastic Microtubes Fabricated by Direct Extrusion. SSRN Electronic Journal.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.