Advanced search
Publication Cover
Hypertension in Pregnancy Volume 24, 2005 - Issue 1
Submit an article Journal homepage
282
Views
27
CrossRef citations to date
0
Altmetric
Original

Villous Explant Culture: Characterization and Evaluation of a Model to Study Trophoblast Invasion

Deborah Newby Maternal and Fetal Medicine Section, Institute of Medical Genetics, Yorkhill, Glasgow, G3 8SJ, UK
,
Leah Marks Maternal and Fetal Medicine Section, Institute of Medical Genetics, Yorkhill, Glasgow, G3 8SJ, UK
,
Frances Cousins Maternal and Fetal Medicine Section, Institute of Medical Genetics, Yorkhill, Glasgow, G3 8SJ, UK
,
Elizabeth Duffie Maternal and Fetal Medicine Section, Institute of Medical Genetics, Yorkhill, Glasgow, G3 8SJ, UK
&
Professor Fiona Lyall Maternal and Fetal Medicine Section, Institute of Medical Genetics, Yorkhill, Glasgow, G3 8SJ, UK; Maternal and Fetal Medicine Section, Institute of Medical Genetics, Yorkhill, Glasgow, G3 8SJ, UK
Pages 75-91 | Published online: 07 Jul 2009

Citations (27)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Haiying Rao, Yuxiang Bai, Fumei Zhang, Qingshu Li, Baimei Zhuang, Xin Luo & Hongbo Qi. (2019) The role of SATB1 in HTR8/SVneo cells and pathological mechanism of preeclampsia. The Journal of Maternal-Fetal & Neonatal Medicine 32:12, pages 2069-2078.
Read now
Joanna James, Win Tun & Alys Clark. (2016) Quantifying trophoblast migration: In vitro approaches to address in vivo situations. Cell Adhesion & Migration 10:1-2, pages 77-87.
Read now
David McCaig & Fiona Lyall. (2009) Hypoxia Upregulates GCM1 in Human Placenta Explants. Hypertension in Pregnancy 28:4, pages 457-472.
Read now

Articles from other publishers (24)

Chandana Tekkatte, Scott A. Lindsay, Erika Duggan, Anelizze Castro-Martínez, Abbas Hakim, Isabella Saldana, Yan Zhang, Jun Zhou, Rachel Sebastian, Yukun Liu, Devin S. Pontigon, Morgan Meads, Tzu Ning Liu, Donald P. Pizzo, John Nolan, Mana M. Parast & Louise C. Laurent. (2023) Identification of optimal conditions for human placental explant culture and extracellular vesicle release. iScience 26:10, pages 108046.
Crossref
Yali Li, Hui Zhao, Ning Li, Chao Yuan, Nana Dong, Jin Wen, Zihui Li, Qun Wang, Lina Wang & Haiting Mao. (2023) BBOX1-AS1 mediates trophoblast cells dysfunction via regulating hnRNPK/GADD45A axis. Biology of Reproduction 108:3, pages 408-422.
Crossref
Mina Popovic & Susana M. Chuva de Sousa Lopes. (2022) Emerging in vitro platforms and omics technologies for studying the endometrium and early embryo-maternal interface in humans. Placenta 125, pages 36-46.
Crossref
Joanna L. James, Abbey Lissaman, Yohanes N. S. Nursalim & Lawrence W. Chamley. (2022) Modelling human placental villous development: designing cultures that reflect anatomy. Cellular and Molecular Life Sciences 79:7.
Crossref
Zi Lv, Li-ling Xiong, Xian Qin, Hua Zhang, Xin Luo, Wei Peng, Mark D. Kilby, Richard Saffery, Philip N. Baker & Hong-bo Qi. (2021) Role of GRK2 in Trophoblast Necroptosis and Spiral Artery Remodeling: Implications for Preeclampsia Pathogenesis. Frontiers in Cell and Developmental Biology 9.
Crossref
Georgia R. Kafer. 2021. Cell-Inspired Materials and Engineering. Cell-Inspired Materials and Engineering 219 234 .
Shingo Io, Eiji Kondoh, Yoshitsugu Chigusa, Kaoru Kawasaki, Masaki Mandai & and Shigehito Yamada. (2020) New era of trophoblast research: integrating morphological and molecular approaches. Human Reproduction Update 26:5, pages 611-633.
Crossref
Junjie Wang, Tanghui Liu, Yasser S. Mahmmod, Zipeng Yang, Jiexing Tan, Zhaowen Ren, Xirui Zhang, Xiaoying Yang, Xiu-Xiang Zhang & Zi-Guo Yuan. (2020) Transcriptome Analysis of Testes and Uterus: Reproductive Dysfunction Induced by Toxoplasma gondii in Mice. Microorganisms 8:8, pages 1136.
Crossref
Myriam Hemberger, Courtney W. Hanna & Wendy Dean. (2019) Mechanisms of early placental development in mouse and humans. Nature Reviews Genetics 21:1, pages 27-43.
Crossref
Houzhu Ding, Nicholas P. Illsley & Robert C. Chang. (2019) 3D Bioprinted GelMA Based Models for the Study of Trophoblast Cell Invasion. Scientific Reports 9:1.
Crossref
Qinyin Deng, Xiru Liu, Zhongmei Yang & Lan Xie. (2021) Expression of N-Acetylglucosaminyltransferase III Promotes Trophoblast Invasion and Migration in Early Human Placenta. Reproductive Sciences 26:10, pages 1373-1381.
Crossref
Jenna Treissman, Victor Yuan, Jennet Baltayeva, Hoa T. Le, Barbara Castellana, Wendy P. Robinson & Alexander G. Beristain. (2019) Low oxygen enhances trophoblast column growth by potentiating differentiation of the extravillous lineage and promoting LOX activity. Development.
Crossref
W.R. Huckle. 2017. Molecular Biology of Placental Development and Disease. Molecular Biology of Placental Development and Disease 29 37 .
J. Prossler, Q. Chen, L. Chamley & J.L. James. (2014) The relationship between TGFβ, low oxygen and the outgrowth of extravillous trophoblasts from anchoring villi during the first trimester of pregnancy. Cytokine 68:1, pages 9-15.
Crossref
X. Liu, H. Mu, X. Luo, X. Xiao, Y. Ding, N. Yin, Q. Deng & H. Qi. (2014) Expression of Gadd45α in human early placenta and its role in trophoblast invasion. Placenta 35:6, pages 370-377.
Crossref
M. Aghababaei, S. Perdu, K. Irvine & A.G. Beristain. (2014) A disintegrin and metalloproteinase 12 (ADAM12) localizes to invasive trophoblast, promotes cell invasion and directs column outgrowth in early placental development. MHR: Basic science of reproductive medicine 20:3, pages 235-249.
Crossref
Schu-Rern Chern, Sheng-Hsiang Li, Chien-Ling Chiu, Hsiao-Ho Chang, Chih-Ping Chen & Edmund I Tsuen Chen. (2011) Spatiotemporal expression of SERPINE2 in the human placenta and its role in extravillous trophoblast migration and invasion. Reproductive Biology and Endocrinology 9:1.
Crossref
Tea Soon ParkManuela GavinaChien-Wen ChenBin SunPang-Ning TengJohnny HuardBridget M. DeasyLudovic ZimmerlinBruno Péault. (2011) Placental Perivascular Cells for Human Muscle Regeneration. Stem Cells and Development 20:3, pages 451-463.
Crossref
Jian Han, Li Li, Jiongyu Hu, Lili Yu, Yingru Zheng, Jianxin Guo, Xiuhui Zheng, Ping Yi & Yuanguo Zhou. (2010) Epidermal Growth Factor Stimulates Human Trophoblast Cell Migration through Rho A and Rho C Activation. Endocrinology 151:4, pages 1732-1742.
Crossref
S.K.M. Seeho, J.H. Park, J. Rowe, J.M. Morris & E.D.M. Gallery. (2008) Villous explant culture using early gestation tissue from ongoing pregnancies with known normal outcomes: the effect of oxygen on trophoblast outgrowth and migration. Human Reproduction 23:5, pages 1170-1179.
Crossref
S. Tartakover-Matalon, N. Cherepnin, M. Kuchuk, L. Drucker, I. Kenis, A. Fishman, M. Pomeranz & M. Lishner. (2007) Impaired migration of trophoblast cells caused by simvastatin is associated with decreased membrane IGF-I receptor, MMP2 activity and HSP27 expression. Human Reproduction 22:4, pages 1161-1167.
Crossref
J. L. James, P. R. Stone & L. W. Chamley. (2006) The effects of oxygen concentration and gestational age on extravillous trophoblast outgrowth in a human first trimester villous explant model. Human Reproduction 21:10, pages 2699-2705.
Crossref
Gendie E. Lash, Harry A. Otun, Barbara A. Innes, Judith N. Bulmer, Roger F. Searle & Stephen C. Robson. (2006) Low Oxygen Concentrations Inhibit Trophoblast Cell Invasion from Early Gestation Placental Explants via Alterations in Levels of the Urokinase Plasminogen Activator System1. Biology of Reproduction 74:2, pages 403-409.
Crossref
Chandana Tekkatte, Erika Duggan, Yan Zhang, Jun Zhou, Rachel Sebastian, Yukun Liu, Devin S. Pontigon, Morgan Meads, Tzu Ning Liu, Donald P. Pizzo, John Nolan, Mana M. Parast & Louise C. Laurent. (2021) Identification of Optimal Conditions for Human Placental Explant Culture and Extracellular Vesicle Release. SSRN Electronic Journal.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.