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P. Pon Matheswari, Radhakrishnan Nandini Asha, J. Ilavarasi Jeyamalar, P. Selvarathy Grace, Dieter Schollmeyer & B. Ravindran Durai Nayagam. (2022) Synthesis, crystal structure, computational, and molecular docking studies of bis {1,1'-[1,3,5-Trimethyl-1,3-phenylenebis(methylene)]di-1H-piperidinium}tetrabromide tri hydrate. Molecular Crystals and Liquid Crystals 744:1, pages 74-91.
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Ayesha Bari, Ahsan Iqbal, Zulfiqar Ali Khan, Sohail Anjum Shahzad & Muhammad Yar. (2020) Synthetic approaches toward piperidine related structures: A review. Synthetic Communications 50:17, pages 2572-2589.
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Anas Shamsi, Moyad Al Shahwan, Shahzaib Ahamad, Md. Imtaiyaz Hassan, Faizan Ahmad & Asimul Islam. (2020) Spectroscopic, calorimetric and molecular docking insight into the interaction of Alzheimer’s drug donepezil with human transferrin: implications of Alzheimer’s drug. Journal of Biomolecular Structure and Dynamics 38:4, pages 1094-1102.
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Ramón Cacabelos. (2007) Donepezil in Alzheimer’s disease: From conventional trials to pharmacogenetics. Neuropsychiatric Disease and Treatment 3:3, pages 303-333.
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Ben Seltzer. (2005) Donepezil: a review. Expert Opinion on Drug Metabolism & Toxicology 1:3, pages 527-536.
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Gustavo C Román & Susan J Rogers. (2004) Donepezil: a clinical review of current and emerging indications. Expert Opinion on Pharmacotherapy 5:1, pages 161-180.
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Shehla Shoukat, Muhammad Amir Zia, Muhammad Uzair, Kotb A. Attia, Asmaa M. Abushady, Sajid Fiaz, Shaukat Ali, Seung Hwan Yang & Ghulam Muhammad Ali. (2023) Bacopa monnieri: A promising herbal approach for neurodegenerative disease treatment supported by in silico and in vitro research. Heliyon 9:11, pages e21161.
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Crossref
Roxanne Vasquez, Leonardo Batista & Teobaldo Cuya. (2023) Computational Study on the Enzyme–Ligand Relationship between Cannabis Phytochemicals and Human Acetylcholinesterase: Implications in Alzheimer’s Disease. The Journal of Physical Chemistry B 127:41, pages 8780-8795.
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Crossref
Meiju Liu, Wenhui Xing, Yao Zou, Kun Hu, Ningbo Gong, Yang Lu & Guanhua Du. (2023) Understanding solvent effects on solvatomorphisms of donepezil-maleic acid. Journal of Molecular Structure, pages 136898.
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Piotr Londzin, Marcin Trawczyński, Urszula Cegieła, Zenon P. Czuba & Joanna Folwarczna. (2023) Effects of Donepezil on the Musculoskeletal System in Female Rats. International Journal of Molecular Sciences 24:10, pages 8991.
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Chencheng Ye. (2023) Mechanism and efficacy of drugs for Alzheimer's disease. Highlights in Science, Engineering and Technology 36, pages 786-791.
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Crossref
Jing-Jing Liang, Tian-Ming Lv, Zhi-Yong Xu, Ning-Ning Du, Bin Lin, Xiao-Xiao Huang & Shao-Jiang Song. (2023) Two new iridoids and triterpenoid analogues from the leaves of Viburnum chingii and their anti-acetylcholinesterase activity. Fitoterapia 165, pages 105400.
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Kholoud I. Eissa, Mona M. Kamel, Lamia W. Mohamed & Asmaa E. Kassab. (2022) Development of new Alzheimer's disease drug candidates using donepezil as a key model. Archiv der Pharmazie 356:1.
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A.V. Kuzikov, R.A. Masamrekh, T.A. Filippova & V.V. Shumyantseva. (2022) Electrochemical Analysis of Metabolites as a Method for Cytochromes P450 Activity Determination. Biomedical Chemistry: Research and Methods 5:4, pages e00176.
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Wenhui Xing, Hongmei Yu, Baoxi Zhang, Meiju Liu, Li Zhang, Fengfeng Wang, Ningbo Gong & Yang Lu. (2022) Quantitative Analysis the Weak Non-Covalent Interactions of the Polymorphs of Donepezil. ACS Omega 7:41, pages 36434-36440.
Crossref
Crossref
Bhuvaneswari Sivaraman, Vijaykumar Raji, Bala Aakash Velmurugan & Ramalakshmi Natarajan. (2022) Acetylcholinesterase Enzyme Inhibitor Molecules with Therapeutic Potential
for Alzheimer's Disease. CNS & Neurological Disorders - Drug Targets 21:5, pages 427-449.
Crossref
Crossref
Maria Podsiedlik, Magdalena Markowicz-Piasecka & Joanna Sikora. (2022) The Influence of Selected Antipsychotic Drugs on Biochemical Aspects of Alzheimer’s Disease. International Journal of Molecular Sciences 23:9, pages 4621.
Crossref
Crossref
Xian-Tao Li. (2022) Alzheimer’s disease therapy based on acetylcholinesterase inhibitor/blocker effects on voltage-gated potassium channels. Metabolic Brain Disease 37:3, pages 581-587.
Crossref
Crossref
Mahdieh Sadeghi, Zakaria Zakariaei, Mostafa Soleymani & Abdollah Malakian. (2022) Occurrence of acute cholinergic syndrome in an infant due to donepezil ingestion. Clinical Case Reports 10:2.
Crossref
Crossref
Narendran Annadurai & Viswanath Das. 2022. Protein Kinase Inhibitors. Protein Kinase Inhibitors
571
596
.
Gerhard N. Ransmayr. 2022. NeuroPsychopharmacotherapy. NeuroPsychopharmacotherapy
4207
4230
.
Khairujjaman Laskar, Mohd Farhan & Aamir Ahmad. (2021) Yb/Chitosan Catalyzed Synthesis of Highly Substituted Piperidine Derivatives for Potential Nuclease Activity and DNA Binding Study. Current Pharmaceutical Design 27:19, pages 2252-2263.
Crossref
Crossref
Gerhard N. Ransmayr. 2020. NeuroPsychopharmacotherapy. NeuroPsychopharmacotherapy
1
24
.
Gurjaspreet Singh, Geetika Sharma, Pinky Satija, Akshpreet Singh, Pawan, Cristóbal E. Ruiz, Daniel G. Silvera, María A. Esteban & Sajeev Soni. (2020) Design and Synthesis of Heterocyclic Encapsulated Organosilatranes for In Silico, In Vitro Antioxidant and Cytotoxicity Evaluation. ChemistrySelect 5:47, pages 15055-15060.
Crossref
Crossref
Archana S. Nayak, Srivani Chodisetti, Shivaprasad Gadag, Usha Yogendra Nayak, Srinikethan Govindan & Keyur Raval. (2020) Tailoring solulan C24 based niosomes for transdermal delivery of donepezil: In vitro characterization, evaluation of pH sensitivity, and microneedle-assisted Ex vivo permeation studies. Journal of Drug Delivery Science and Technology 60, pages 101945.
Crossref
Crossref
Bianca Xavier de Farias, Ana Beatriz Costa, Nicole Alessandra Engel, Mariana Pereira de Souza Goldim, Cristini da Rosa Turatti, Anderson Cargnin-Cavalho, Jucélia Jeremias Fortunato, Fabricia Petronilho, Isabela Casagrande Jeremias & Gislaine Tezza Rezin. (2020) Donepezil Prevents Inhibition of Cerebral Energetic Metabolism Without Altering Behavioral Parameters in Animal Model of Obesity. Neurochemical Research 45:10, pages 2487-2498.
Crossref
Crossref
Stephen Thornton & Todd Crane. 2020. Toxicology Cases for the Clinical and Forensic Laboratory. Toxicology Cases for the Clinical and Forensic Laboratory
485
487
.
Laura Blaikie, Graeme Kay & Paul Kong Thoo Lin. (2019) Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands. MedChemComm 10:12, pages 2052-2072.
Crossref
Crossref
Lindon W. K. Moodie, Kristina Sepčić, Tom Turk, Robert Frangež & Johan Svenson. (2019) Natural cholinesterase inhibitors from marine organisms. Natural Product Reports 36:8, pages 1053-1092.
Crossref
Crossref
Jacob Horsager, Tatyana D. Fedorova, Nathalie V.D. Berge, Mette W. Klinge, Karoline Knudsen, Allan K. Hansen, Aage K.O. Alstrup, Klaus Krogh, Lars Gormsen & Per Borghammer. (2019)
Cardiac
11
C-Donepezil Binding Increases With Age in Healthy Humans: Potentially Signifying Sigma-1 Receptor Upregulation
. Journal of Cardiovascular Pharmacology and Therapeutics 24:4, pages 365-370.
Crossref
Crossref
James T. BrewsterIIII, Simone Dell’Acqua, Danny Q. Thach & Jonathan L. Sessler. (2018) Classics in Chemical Neuroscience: Donepezil. ACS Chemical Neuroscience 10:1, pages 155-167.
Crossref
Crossref
Gurpreet Kaur, Mamta Devi, Anjana Kumari, Rekha Devi & Bubun Banerjee. (2018) One-Pot Pseudo Five Component Synthesis of Biologically Relevant 1,2,6-Triaryl-4-arylamino-piperidine-3-ene-3- carboxylates: A Decade Update. ChemistrySelect 3:34, pages 9892-9910.
Crossref
Crossref
Zübeyde Erbayraktar, Ahmet Evlice, Görsev Yener & N. Nuray Ulusu. (2018) Effects of donepezil on liver and kidney functions for the treatment of Alzheimer’s disease. Journal of Integrative Neuroscience 16:3, pages 335-346.
Crossref
Crossref
Bosai He, Fanxing Xu, Feng Xiao, Tingxu Yan, Bo Wu, Kaishun Bi & Ying Jia. (2017) Neuroprotective effects of nootkatone from Alpiniae oxyphyllae Fructus against amyloid-β-induced cognitive impairment. Metabolic Brain Disease 33:1, pages 251-259.
Crossref
Crossref
Adam Kostelnik & Miroslav Pohanka. (2018) Inhibition of Acetylcholinesterase and Butyrylcholinesterase by a Plant Secondary Metabolite Boldine. BioMed Research International 2018, pages 1-5.
Crossref
Crossref
Suvankar Das, Cristiane J. da Silva, Marina de M. Silva, Maria Dayanne de A. Dantas, Ângelo de Fátima, Ana Lúcia T. Góis Ruiz, Cleiton M. da Silva, João Ernesto de Carvalho, Josué C.C. Santos, Isis M. Figueiredo, Edeildo F. da Silva-Júnior, Thiago M. de Aquino, João X. de Araújo-Júnior, Goutam Brahmachari & Luzia Valentina Modolo. (2018) Highly functionalized piperidines: Free radical scavenging, anticancer activity, DNA interaction and correlation with biological activity. Journal of Advanced Research 9, pages 51-61.
Crossref
Crossref
Shahrina Alam, Kaelyn Skye Lingenfelter, Aaron M. Bender & Craig W. Lindsley. (2017) Classics in Chemical Neuroscience: Memantine. ACS Chemical Neuroscience 8:9, pages 1823-1829.
Crossref
Crossref
Kinga Gawel, Ewa Gibula-Bruzda, Marcin Dziedzic, Malgorzata Jenda-Wojtanowska, Marta Marszalek-Grabska, Jerzy Silberring & Jolanta H. Kotlinska. (2017) Cholinergic activation affects the acute and chronic antinociceptive effects of morphine. Physiology & Behavior 169, pages 22-32.
Crossref
Crossref
Maria Amat-Foraster, Steven C. Leiser, Kjartan F. Herrik, Nelly Richard, Claus Agerskov, Christoffer Bundgaard, Jesper F. Bastlund & Inge E.M. de Jong. (2017) The 5-HT6 receptor antagonist idalopirdine potentiates the effects of donepezil on gamma oscillations in the frontal cortex of anesthetized and awake rats without affecting sleep-wake architecture. Neuropharmacology 113, pages 45-59.
Crossref
Crossref
Mullah Muhaiminul Islam & Sivaprasad Mitra. (2016) Cholinergic inhibitors replace thioflavin-T from acetylcholinesterase binding pocket: A potential fluorescence based molecular switch. Chemical Physics Letters 664, pages 63-69.
Crossref
Crossref
Mullah Muhaiminul Islam, Arun Bahadur Gurung, Atanu Bhattacharjee, Kripamoy Aguan & Sivaprasad Mitra. (2016) Human serum albumin reduces the potency of acetylcholinesterase inhibitor based drugs for Alzheimer's disease. Chemico-Biological Interactions 249, pages 1-9.
Crossref
Crossref
Chad M. VanDenBerg. 2016. Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents. Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents
551
563
.
Jan Korabecny, Martin Andrs, Eugenie Nepovimova, Rafael Dolezal, Katerina Babkova, Anna Horova, David Malinak, Eva Mezeiova, Lukas Gorecki, Vendula Sepsova, Martina Hrabinova, Ondrej Soukup, Daniel Jun & Kamil Kuca. (2015) 7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer’s Disease Treatment. Molecules 20:12, pages 22084-22101.
Crossref
Crossref
Thibault B. Ali, Thomas R. Schleret, Brian M. Reilly, Winston Yuchen Chen & Ruben Abagyan. (2015) Adverse Effects of Cholinesterase Inhibitors in Dementia, According to the Pharmacovigilance Databases of the United-States and Canada. PLOS ONE 10:12, pages e0144337.
Crossref
Crossref
Trine Gjerløff, Tatyana Fedorova, Karoline Knudsen, Ole L. Munk, Adjmal Nahimi, Steen Jacobsen, Erik H. Danielsen, Astrid J. Terkelsen, John Hansen, Nicola Pavese, David J. Brooks & Per Borghammer. (2015) Imaging acetylcholinesterase density in peripheral organs in Parkinson's disease with 11C-donepezil PET. Brain 138:3, pages 653-663.
Crossref
Crossref
Yun Ju Chae, Hong Joon Lee, Ji Hyun Jeon, In-Beom Kim, Jin-Sung Choi, Ki-Wug Sung & Sang June Hahn. (2015) Effects of donepezil on hERG potassium channels. Brain Research 1597, pages 77-85.
Crossref
Crossref
Marie Vandeput, Cobra Parsajoo, Jérôme Vanheuverzwijn, Stéphanie Patris, Yavuz Yardim, Alexandre le Jeune, Ahmad Sarakbi, Dominique Mertens & Jean-Michel Kauffmann. (2015) Flow-through enzyme immobilized amperometric detector for the rapid screening of acetylcholinesterase inhibitors by flow injection analysis. Journal of Pharmaceutical and Biomedical Analysis 102, pages 267-275.
Crossref
Crossref
Alanna McEneny-King, Andrea N. Edginton & Praveen P.N. Rao. (2015) Investigating the binding interactions of the anti-Alzheimer’s drug donepezil with CYP3A4 and P-glycoprotein. Bioorganic & Medicinal Chemistry Letters 25:2, pages 297-301.
Crossref
Crossref
Yvonne Boyle, Disala Fernando, Hazel Kurz, Sam R. Miller, Mauro Zucchetto & James Storey. (2014) The effect of a combination of gabapentin and donepezil in an experimental pain model in healthy volunteers: Results of a randomized controlled trial. Pain 155:12, pages 2510-2516.
Crossref
Crossref
Trine Gjerløff, Steen Jakobsen, Adjmal Nahimi, Ole L. Munk, Dirk Bender, Aage K.O. Alstrup, Karina H. Vase, Søren B. Hansen, David J. Brooks & Per Borghammer. (2014)
In Vivo Imaging of Human Acetylcholinesterase Density in Peripheral Organs Using
11
C-Donepezil: Dosimetry, Biodistribution, and Kinetic Analyses
. Journal of Nuclear Medicine 55:11, pages 1818-1824.
Crossref
Crossref
Caroline G.Y. Lau & Yusuke Marikawa. (2014) Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil. Molecular Reproduction and Development 81:11, pages 994-1008.
Crossref
Crossref
Stephen L. Thornton & Richard F. Clark. (2014) Encephalopathy From Unintentional Donepezil and Memantine Ingestion. Pediatric Emergency Care 30:9, pages 649-650.
Crossref
Crossref
Ümide Demir Özkay, Özgür Devrim Can, Yusuf Özkay & Yusuf Öztürk. (2012) Effect of benzothiazole/piperazine derivatives on intracerebroventricular streptozotocin-induced cognitive deficits. Pharmacological Reports 64:4, pages 834-847.
Crossref
Crossref
Kazufumi Hirano, Kirsten L. Searle, Shabina Nasir, Chiu-Cheong Aw, Edward R. Browne & A. Richard Rutter. (2011) In vivo 5-HT6 receptor occupancy by antipsychotic drugs in the rat brain. Neuroscience Letters 503:3, pages 240-243.
Crossref
Crossref
Subas Sakya & Kapil Karki. 2010. Modern Drug Synthesis. Modern Drug Synthesis
249
274
.
Mi‐Hwa Kim, Han‐Joo Maeng, Kyung‐Ha Yu, Kyeong‐Ryoon Lee, Takashi Tsuruo, Dae‐Duk Kim, Chang‐Koo Shim & Suk‐Jae Chung. (2010) Evidence of carrier‐mediated transport in the penetration of donepezil into the rat brain. Journal of Pharmaceutical Sciences 99:3, pages 1548-1566.
Crossref
Crossref
M Almasieh, Y Zhou, M E Kelly, C Casanova & A Di Polo. (2010) Structural and functional neuroprotection in glaucoma: role of galantamine-mediated activation of muscarinic acetylcholine receptors. Cell Death & Disease 1:2, pages e27-e27.
Crossref
Crossref
Yasco Aracava, Edna F. R. Pereira, Miriam Akkerman, Michael Adler & Edson X. Albuquerque. (2009) Effectiveness of Donepezil, Rivastigmine, and (±)Huperzine A in Counteracting the Acute Toxicity of Organophosphorus Nerve Agents: Comparison with Galantamine. Journal of Pharmacology and Experimental Therapeutics 331:3, pages 1014-1024.
Crossref
Crossref
Bhavin N. Patel, Naveen Sharma, Mallika Sanyal & Pranav S. Shrivastav. (2008) Quantitation of donepezil and its active metabolite 6-O-desmethyl donepezil in human plasma by a selective and sensitive liquid chromatography–tandem mass spectrometric method. Analytica Chimica Acta 629:1-2, pages 145-157.
Crossref
Crossref
Kazufumi Hirano, Richard A. Rutter, Neil D. Miller & Paul F. Chapman. (2008)
P4‐319: 5‐HT
6
receptor antagonists modulate brain monoaminergic neurotransmission: Different mode of action from acetylcholinesterase (AchE) inhibitors
. Alzheimer's & Dementia 4:4S_Part_24.
Crossref
Crossref
G. Ozturk, S. Alp & S. Timur. (2007) A fluorescent biosensor based on acetylcholinesterase and 5-oxazolone derivative immobilized in polyvinylchloride (PVC) matrix. Journal of Molecular Catalysis B: Enzymatic 47:3-4, pages 111-116.
Crossref
Crossref
R. Schliebs & T. Arendt. (2006) The significance of the cholinergic system in the brain during aging and in Alzheimer’s disease. Journal of Neural Transmission 113:11, pages 1625-1644.
Crossref
Crossref
B. Potier, A. Jouvenceau, J. Epelbaum & P. Dutar. (2006) Age-related alterations of GABAergic input to CA1 Pyramidal neurons and its control by nicotinic acetylcholine receptors in rat hippocampus. Neuroscience 142:1, pages 187-201.
Crossref
Crossref
Kenichiro Nakashima, Keiko Itoh, Michio Kono, Mihoko N. Nakashima & Mitsuhiro Wada. (2006) Determination of donepezil hydrochloride in human and rat plasma, blood and brain microdialysates by HPLC with a short C30 column. Journal of Pharmaceutical and Biomedical Analysis 41:1, pages 201-206.
Crossref
Crossref
Georg Grön, Matthias Kirstein, Axel Thielscher, Matthias W. Riepe & Manfred Spitzer. (2005) Cholinergic enhancement of episodic memory in healthy young adults. Psychopharmacology 182:1, pages 170-179.
Crossref
Crossref
Cristina Paci, Rocco Di Mascio, Roberto Gobbato, Terenzio Carboni, Sandro Sanguigni, Stefania Sobrini, Vittoria Urbano, Federico Olivieri & Luigi Curatola. (2005) Donepezil in Vascular Dementia. Clinical Drug Investigation 25:4, pages 271-276.
Crossref
Crossref
Bruno Bontempi, Kevin T Whelan, Victoria B Risbrough, G Kenneth Lloyd & Frédérique Menzaghi. (2003) Cognitive Enhancing Properties and Tolerability of Cholinergic Agents in Mice: A Comparative Study of Nicotine, Donepezil, and SIB-1553A, a Subtype-Selective Ligand for Nicotinic Acetylcholine Receptors. Neuropsychopharmacology 28:7, pages 1235-1246.
Crossref
Crossref
Ya-Ping Pan, Xiang-Hua Xu & Xiao-Liang Wang. (2003) Galantamine blocks delayed rectifier, but not transient outward potassium current in rat dissociated hippocampal pyramidal neurons. Neuroscience Letters 336:1, pages 37-40.
Crossref
Crossref