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Application of mechanism-based CYP inhibition for predicting drug–drug interactions

& , MD PhD
Pages 579-605 | Published online: 25 May 2009

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Wenqin Liu, Jian Shi, Lijun Zhu, Lingna Dong, Feifei Luo, Min Zhao, Ying Wang, Ming Hu, Linlin Lu & Zhongqiu Liu. (2015) Reductive metabolism of oxymatrine is catalyzed by microsomal CYP3A4. Drug Design, Development and Therapy 9, pages 5771-5783.
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David M Stresser, Jialin Mao, Jane R Kenny, Barry C Jones & Kenneth Grime. (2014) Exploring concepts of in vitro time-dependent CYP inhibition assays. Expert Opinion on Drug Metabolism & Toxicology 10:2, pages 157-174.
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Li-Ping Yang, Zhi-Wei Zhou, Xiao-Wu Chen, Chun Guang Li, Kevin B. Sneed, Jun Liang & Shu-Feng Zhou. (2012) Computational and in vitro studies on the inhibitory effects of herbal compounds on human cytochrome P450 1A2. Xenobiotica 42:3, pages 238-255.
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Dominic D. Martinelli. (2023) Machine learning for metabolomics research in drug discovery. Intelligence-Based Medicine 8, pages 100101.
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Jing Ning, Zhenhao Tian, Jiayue Wang, Bo Wang, Xiangge Tian, Zhenlong Yu, Xiaokui Huo, Lei Feng, Jingnan Cui, Tony D. James & Xiaochi Ma. (2021) Rational Design of a Two‐Photon Fluorescent Probe for Human Cytochrome P450 3A and the Visualization of Mechanism‐Based Inactivation. Angewandte Chemie International Edition 61:5.
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Jing Ning, Zhenhao Tian, Jiayue Wang, Bo Wang, Xiangge Tian, Zhenlong Yu, Xiaokui Huo, Lei Feng, Jingnan Cui, Tony D. James & Xiaochi Ma. (2021) Rational Design of a Two‐Photon Fluorescent Probe for Human Cytochrome P450 3A and the Visualization of Mechanism‐Based Inactivation. Angewandte Chemie 134:5.
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Makiko Yamada, Shin-ichi Inoue, Daisuke Sugiyama, Yumi Nishiya, Tomoko Ishizuka, Akiko Watanabe, Kengo Watanabe, Shinji Yamashita & Nobuaki Watanabe. (2020) Critical Impact of Drug-Drug Interactions via Intestinal CYP3A in the Risk Assessment of Weak Perpetrators Using Physiologically Based Pharmacokinetic Models. Drug Metabolism and Disposition 48:4, pages 288-296.
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Jaydeep Yadav, Erickson Paragas, Ken Korzekwa & Swati Nagar. (2020) Time-dependent enzyme inactivation: Numerical analyses of in vitro data and prediction of drug-drug interactions. Pharmacology & Therapeutics 206, pages 107449.
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Pengfei Chu, Libo He, Denghui Zhu, Rong Huang, Lanjie Liao, Yongming Li, Zuoyan Zhu & Yaping Wang. (2019) Identification, expression and functional characterisation of CYP1A in grass carp (Ctenopharyngodon idella). Fish & Shellfish Immunology 95, pages 35-43.
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Jaydeep Yadav, Ken Korzekwa & Swati Nagar. (2018) Improved Predictions of Drug–Drug Interactions Mediated by Time-Dependent Inhibition of CYP3A. Molecular Pharmaceutics 15:5, pages 1979-1995.
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Xavier Boulenc, Olivier Nicolas, Stéphanie Hermabessière, Isabelle Zobouyan, Valérie Martin, Yves Donazzolo & Céline Ollier. (2014) CYP3A4-based drug–drug interaction: CYP3A4 substrates’ pharmacokinetic properties and ketoconazole dose regimen effect. European Journal of Drug Metabolism and Pharmacokinetics 41:1, pages 45-54.
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Lili Wu, Wanping Zhong, Junjin Liu, Weichao Han, Shilong Zhong, Qiang Wei, Shuwen Liu & Lan Tang. (2015) Human microsomal cyttrochrome P450-mediated reduction of oxysophocarpine, an active and highly toxic constituent derived from Sophora flavescens species, and its intestinal absorption and metabolism in rat. Fitoterapia 105, pages 26-36.
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Youngjae Kim, Jeeyeon Kim, Sora Kim, Yooran Ki, Seon Hee Seo, Jinsung Tae, Min Kyung Ko, Hyun-Seo Jang, Eun Jeong Lim, Chiman Song, YoonJeong Cho, Hae-Young Koh, Youhoon Chong, Il Han Choo, Gyochang Keum, Sun-Joon Min & Hyunah Choo. (2014) Novel thienopyrimidinones as mGluR1 antagonists. European Journal of Medicinal Chemistry 85, pages 629-637.
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Andrew V. Stachulski, Thomas A. Baillie, B. Kevin Park, R. Scott Obach, Deepak K. Dalvie, Dominic P. Williams, Abhishek Srivastava, Sophie L. Regan, Daniel J. Antoine, Christopher E. P. Goldring, Alvin J. L. Chia, Neil R. Kitteringham, Laura E. Randle, Hayley Callan, J. Luis Castrejon, John Farrell, Dean J. Naisbitt & Martin S. Lennard. (2013) The Generation, Detection, and Effects of Reactive Drug Metabolites. Medicinal Research Reviews 33:5, pages 985-1080.
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Takeshi Akiyoshi, Marie Ito, Saori Murase, Mitsue Miyazaki, F. Peter Guengerich, Katsunori Nakamura, Koujirou Yamamoto & Hisakazu Ohtani. (2013) Mechanism-based Inhibition Profiles of Erythromycin and Clarithromycin with Cytochrome P450 3A4 Genetic Variants. Drug Metabolism and Pharmacokinetics 28:5, pages 411-415.
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Ming Yao, Hong Cai & Mingshe Zhu. 2012. ADME‐Enabling Technologies in Drug Design and Development. ADME‐Enabling Technologies in Drug Design and Development 213 232 .
Alexander V. LyubimovJames M. MKim. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 28 .
Assaf Gottlieb, Gideon Y Stein, Yoram Oron, Eytan Ruppin & Roded Sharan. (2012) INDI: a computational framework for inferring drug interactions and their associated recommendations. Molecular Systems Biology 8:1.
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M. Abid Masood, Matthew D. Selby, Andrew S. Bell, Andrew C. Mansfield, Mark Gardner, Graham F. Smith, Charlotte Lane, Helen Kenyon-Edwards, Rachel Osborne, Rhys M. Jones, Wai L. Liu, Christopher D. Brown, Nicholas Clarke, Francesca Perrucio & Charles E. Mowbray. (2011) Discovery of a series of potent and selective human H4 antagonists using ligand efficiency and libraries to explore structure–activity relationship (SAR). Bioorganic & Medicinal Chemistry Letters 21:21, pages 6591-6595.
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Kaisa A. Salminen, Jukka Leppänen, Jarkko I. Venäläinen, Markku Pasanen, Seppo Auriola, Risto O. Juvonen & Hannu Raunio. (2011) Simple, Direct, and Informative Method for the Assessment of CYP2C19 Enzyme Inactivation Kinetics. Drug Metabolism and Disposition 39:3, pages 412-418.
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V. Hafner, B. Grün, C. Markert, D. Czock, G. Mikus & W.E. Haefeli. (2010) ArzneimittelinteraktionenDrug interactions. Der Internist 51:3, pages 359-370.
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