Citations (45)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (1)
Icilio Cavero. (2009) Exploratory Safety Pharmacology: a new safety paradigm to de-risk drug candidates prior to selection for regulatory science investigations. Expert Opinion on Drug Safety 8:6, pages 627-647.
Read now
Read now
Articles from other publishers (44)
Yanyan Qu, Ting Li, Zhichao Liu, Dongying Li & Weida Tong. (2023) DICTrank: The largest reference list of 1318 human drugs ranked by risk of drug-induced cardiotoxicity using FDA labeling. Drug Discovery Today 28:11, pages 103770.
Crossref
Crossref
Priyadharshni Muniyandi, Colin O’Hern, Mirel Adrian Popa & Aitor Aguirre. (2023) Biotechnological advances and applications of human pluripotent stem cell-derived heart models. Frontiers in Bioengineering and Biotechnology 11.
Crossref
Crossref
Xiaoli Tang, Zengwu Wang, Shengshou Hu & Bingying Zhou. (2022) Assessing Drug-Induced Mitochondrial Toxicity in Cardiomyocytes: Implications for Preclinical Cardiac Safety Evaluation. Pharmaceutics 14:7, pages 1313.
Crossref
Crossref
Qian Zhang & Lei Wu. (2022) In Vitro and In Vivo Cardioprotective Effects of Curcumin against Doxorubicin-Induced Cardiotoxicity: A Systematic Review. Journal of Oncology 2022, pages 1-16.
Crossref
Crossref
Mohamed M. Bekhite & P. Christian Schulze. (2021) Human Induced Pluripotent Stem Cell as a Disease Modeling and Drug Development Platform—A Cardiac Perspective. Cells 10:12, pages 3483.
Crossref
Crossref
Kenichi Arai, Takahiro Kitsuka & Koichi Nakayama. (2021) Scaffold-based and scaffold-free cardiac constructs for drug testing. Biofabrication 13:4, pages 042001.
Crossref
Crossref
Natthaphat Siri-Angkul, Behzad Dadfar, Riya Jaleel, Jazna Naushad, Jaseela Parambathazhath, Angelia Doye, Lai-Hua Xie & Judith Gwathmey. (2021) Calcium and Heart Failure: How Did We Get Here and Where Are We Going?. International Journal of Molecular Sciences 22:14, pages 7392.
Crossref
Crossref
Ferdous B. Finklea, Yuan Tian, Petra Kerscher, Wen J. Seeto, Morgan E. Ellis & Elizabeth A. Lipke. (2021) Engineered cardiac tissue microsphere production through direct differentiation of hydrogel-encapsulated human pluripotent stem cells. Biomaterials 274, pages 120818.
Crossref
Crossref
Hubert Dirven, Gunn E. Vist, Sricharan Bandhakavi, Jyotsna Mehta, Seneca E. Fitch, Pandora Pound, Rebecca Ram, Breanne Kincaid, Cathalijn H. C. Leenaars, Minjun Chen, Robert A. Wright & Katya Tsaioun. (2021) Performance of preclinical models in predicting drug-induced liver injury in humans: a systematic review. Scientific Reports 11:1.
Crossref
Crossref
Moustafa H. Meki, Jessica M. Miller & Tamer M. A. Mohamed. (2021) Heart Slices to Model Cardiac Physiology. Frontiers in Pharmacology 12.
Crossref
Crossref
Kenichi Arai & Koichi Nakayama. 2021. Kenzan Method for Scaffold-Free Biofabrication. Kenzan Method for Scaffold-Free Biofabrication
149
164
.
Erastus Nembu Nembo, Jürgen Hescheler & Filomain Nguemo. (2020) Stem cells in natural product and medicinal plant drug discovery—An overview of new screening approaches. Biomedicine & Pharmacotherapy 131, pages 110730.
Crossref
Crossref
Mayumi Ikeda, Takami Akagi, Masao Nagao & Mitsuru Akashi. (2020) Formulation Stability of Amphiphilic Poly(γ-Glutamic Acid) Nanoparticle and Evaluation of Cardiotoxicity of NPs With Human iPSC-Derived 3D-Cardiomyocyte Tissues. Journal of Pharmaceutical Sciences 109:10, pages 2969-2974.
Crossref
Crossref
Mahnaz Maddah, Mohammad A. Mandegar, Keri Dame, Francis Grafton, Kevin Loewke & Alexandre J.S. Ribeiro. (2020) Quantifying drug-induced structural toxicity in hepatocytes and cardiomyocytes derived from hiPSCs using a deep learning method. Journal of Pharmacological and Toxicological Methods 105, pages 106895.
Crossref
Crossref
Suraj Kannan & Chulan Kwon. (2019) Regulation of cardiomyocyte maturation during critical perinatal window. The Journal of Physiology 598:14, pages 2941-2956.
Crossref
Crossref
Kenichi Arai, Daiki Murata, Shoko Takao, Anna Nakamura, Manabu Itoh, Takahiro Kitsuka & Koichi Nakayama. (2020) Drug response analysis for scaffold-free cardiac constructs fabricated using bio-3D printer. Scientific Reports 10:1.
Crossref
Crossref
Matthieu Dallons, Manon Delcourt, Corentin Schepkens, Manuel Podrecca & Jean-Marie Colet. (2020) A Comparative Study of Rat Urine 1H-NMR Metabolome Changes Presumably Arising from Isoproterenol-Induced Heart Necrosis Versus Clarithromycin-Induced QT Interval Prolongation. Biology 9:5, pages 98.
Crossref
Crossref
Pelin Golforoush & Michael D. Schneider. (2020) Intensive care for human hearts in pluripotent stem cell models. npj Regenerative Medicine 5:1.
Crossref
Crossref
T. I. Zohdi. (2018) Electrodynamic machine-learning-enhanced fault-tolerance of robotic free-form printing of complex mixtures. Computational Mechanics 63:5, pages 913-929.
Crossref
Crossref
Caroline R. Archer, Rebecca Sargeant, Jayati Basak, James Pilling, Jennifer R. Barnes & Amy Pointon. (2018) Characterization and Validation of a Human 3D Cardiac Microtissue for the Assessment of Changes in Cardiac Pathology. Scientific Reports 8:1.
Crossref
Crossref
Aditi Jain & Vibha Rani. (2017) Mode of treatment governs curcumin response on doxorubicin-induced toxicity in cardiomyoblasts. Molecular and Cellular Biochemistry 442:1-2, pages 81-96.
Crossref
Crossref
Aditi Jain & Vibha Rani. (2018) Anti-hypotensive drug induced cardiotoxicity: an in vitro study. In Vitro Cellular & Developmental Biology - Animal 54:2, pages 92-98.
Crossref
Crossref
Kiran Musunuru, Farah Sheikh, Rajat M. Gupta, Steven R. Houser, Kevin O. Maher, David J. Milan, Andre Terzic & Joseph C. Wu. (2018) Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling and Precision Medicine: A Scientific Statement From the American Heart Association. Circulation: Genomic and Precision Medicine 11:1.
Crossref
Crossref
Maki TakedaShigeru MiyagawaSatsuki FukushimaAtsuhiro SaitoEmiko ItoAkima HaradaRyohei MatsuuraHiroko IseokaNagako SougawaNoriko Mochizuki-OdaMichiya MatsusakiMitsuru AkashiYoshiki Sawa. (2018)
Development of
In Vitro
Drug-Induced Cardiotoxicity Assay by Using Three-Dimensional Cardiac Tissues Derived from Human Induced Pluripotent Stem Cells
. Tissue Engineering Part C: Methods 24:1, pages 56-67.
Crossref
Crossref
P. José Gouveia, S. Rosa, L. Ricotti, B. Abecasis, H.V. Almeida, L. Monteiro, J. Nunes, F. Sofia Carvalho, M. Serra, S. Luchkin, A. Leonidovitch Kholkin, P. Marques Alves, P. Jorge Oliveira, R. Carvalho, A. Menciassi, R. Pires das Neves & L. Silva Ferreira. (2017) Flexible nanofilms coated with aligned piezoelectric microfibers preserve the contractility of cardiomyocytes. Biomaterials 139, pages 213-228.
Crossref
Crossref
Carlota Oleaga, Gregg Legters, L. Richard Bridges, Lee Kumanchik, Candace Martin, Yunqing Cai, Mark Schnepper, Christopher W. McAleer, Christopher J. Long & James J. Hickman. 2017. Stem Cell-Derived Models in Toxicology. Stem Cell-Derived Models in Toxicology
229
246
.
Kyuri Kim, Naseem Chini, David G. Fairchild, Steven K. Engle, William J. Reagan, Sandra D. Summers & Jon C. Mirsalis. (2016) Evaluation of Cardiac Toxicity Biomarkers in Rats from Different Laboratories. Toxicologic Pathology 44:8, pages 1072-1083.
Crossref
Crossref
Elena Matsa, John H. Ahrens & Joseph C. Wu. (2016) Human Induced Pluripotent Stem Cells as a Platform for Personalized and Precision Cardiovascular Medicine. Physiological Reviews 96:3, pages 1093-1126.
Crossref
Crossref
Stephanie M. Ravenscroft, Amy Pointon, Awel W. Williams, Michael J. Cross & James E. Sidaway. (2016) Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues. Toxicological Sciences 152:1, pages 99-112.
Crossref
Crossref
Chris Denning, Viola Borgdorff, James Crutchley, Karl S.A. Firth, Vinoj George, Spandan Kalra, Alexander Kondrashov, Minh Duc Hoang, Diogo Mosqueira, Asha Patel, Ljupcho Prodanov, Divya Rajamohan, William C. Skarnes, James G.W. Smith & Lorraine E. Young. (2016) Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1863:7, pages 1728-1748.
Crossref
Crossref
Divya RajamohanSpandan KalraMinh Duc HoangVinoj GeorgeAndrew StaniforthHugh RussellXuebin YangChris Denning. (2016) Automated Electrophysiological and Pharmacological Evaluation of Human Pluripotent Stem Cell-Derived Cardiomyocytes. Stem Cells and Development 25:6, pages 439-452.
Crossref
Crossref
Amy Pointon, Alexander R. Harmer, Ian L. Dale, Najah Abi-Gerges, Joanne Bowes, Christopher Pollard & Helen Garside. (2015) Assessment of Cardiomyocyte Contraction in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Toxicological Sciences 144:2, pages 227-237.
Crossref
Crossref
Benben Song, Yashu Liu, Toufan Parman, Shufeng Liu, Jennifer K. Miller, Xiaohua Liu, Mary J. Tanga & Jon Mirsalis. (2014) Quantitative Proteomics for Cardiac Biomarker Discovery Using Isoproterenol-Treated Nonhuman Primates. Journal of Proteome Research 13:12, pages 5909-5917.
Crossref
Crossref
Yuping Wang, Jurgen Borlak & Weida Tong. 2014. Genomic Biomarkers for Pharmaceutical Development. Genomic Biomarkers for Pharmaceutical Development
127
155
.
Joanna Parkinson, Anne S.Y. Chain, Piet H. van der Graaf & Sandra A.G. Visser. 2014. Applied Pharmacometrics. Applied Pharmacometrics
189
227
.
Yashu Liu, Toufan Parman, Bridget Schneider, Benben Song, Amit K. Galande, Dave Anderson & Jon Mirsalis. (2013) Serum Biomarkers Reveal Long-term Cardiac Injury in Isoproterenol-treated African Green Monkeys. Journal of Proteome Research 12:4, pages 1830-1837.
Crossref
Crossref
Amy Pointon, Najah Abi-Gerges, Michael J. Cross & James E. Sidaway. (2013) Phenotypic Profiling of Structural Cardiotoxins In Vitro Reveals Dependency on Multiple Mechanisms of Toxicity. Toxicological Sciences 132:2, pages 317-326.
Crossref
Crossref
Fabio Cerignoli, David Charlot, Ross Whittaker, Randy Ingermanson, Piyush Gehalot, Alex Savchenko, David J. Gallacher, Rob Towart, Jeffrey H. Price, Patrick M. McDonough & Mark Mercola. (2012) High throughput measurement of Ca2+ dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry. Journal of Pharmacological and Toxicological Methods 66:3, pages 246-256.
Crossref
Crossref
Shreesh Ojha, Mahaveer Golechha, Santosh Kumari & Dharamvir Singh Arya. (2011)
Protective effect of
Emblica officinalis
(amla) on isoproterenol-induced cardiotoxicity in rats
. Toxicology and Industrial Health 28:5, pages 399-411.
Crossref
Crossref
DL Misner, C Frantz, L Guo, MR Gralinski, PB Senese, J Ly, M Albassam & KL Kolaja. (2012) Investigation of mechanism of drug‐induced cardiac injury and torsades de pointes in cynomolgus monkeys. British Journal of Pharmacology 165:8, pages 2771-2786.
Crossref
Crossref
Jay W. Schneider & Mark Mercola. 2012. Muscle. Muscle
707
720
.
Alexander Strigun, Judith Wahrheit, Simone Beckers, Elmar Heinzle & Fozia Noor. (2011) Metabolic profiling using HPLC allows classification of drugs according to their mechanisms of action in HL-1 cardiomyocytes. Toxicology and Applied Pharmacology 252:2, pages 183-191.
Crossref
Crossref
Rebecca K Rowntree & John D McNeish. (2010) Induced pluripotent stem cells: opportunities as research and development tools in 21st century drug discovery. Regenerative Medicine 5:4, pages 557-568.
Crossref
Crossref
Jian-Yong Qian & Liang Guo. (2010) Altered cytosolic Ca2+ dynamics in cultured Guinea pig cardiomyocytes as an in vitro model to identify potential cardiotoxicants. Toxicology in Vitro 24:3, pages 960-972.
Crossref
Crossref