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Review

An update on the dietary ligands of the AhR

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Pages 1429-1447 | Published online: 25 Oct 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Wensi Xu, Shunya Saiki, Takumi Myojin, Yujia Liu, Beiwei Zhu, Yoshiyuki Murata, Hitoshi Ashida, Makoto Tsunenaga & Yoshimasa Nakamura. (2018) Lycii fructus extract ameliorates hydrogen peroxide-induced cytotoxicity through indirect antioxidant action. Bioscience, Biotechnology, and Biochemistry 82:10, pages 1812-1820.
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Rika Nakai, Shun Fukuda, Masaya Kawase, Yoko Yamashita & Hitoshi Ashida. (2018) Curcumin and its derivatives inhibit 2,3,7,8,-tetrachloro-dibenzo-p-dioxin-induced expression of drug metabolizing enzymes through aryl hydrocarbon receptor-mediated pathway. Bioscience, Biotechnology, and Biochemistry 82:4, pages 616-628.
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Hanna Szaefer, Violetta Krajka-Kuźniak, Barbara Licznerska, Agnieszka Bartoszek & Wanda Baer-Dubowska. (2015) Cabbage Juices and Indoles Modulate the Expression Profile of AhR, ERα, and Nrf2 in Human Breast Cell Lines. Nutrition and Cancer 67:8, pages 1344-1356.
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L. Ribonnet, E. van der Heiden, I. Nobels, A. Chaumont, A.-S. Remacle, S. De Saeger, Y.-J. Schneider, M.-L. Scippo, R. Blust, L. Pussemier & Y. Larondelle. (2011) Potential of an in vitro toolbox combined with exposure data as a first step for the risk assessment of dietary chemical contaminants. Food Additives & Contaminants: Part A 28:9, pages 1136-1158.
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Zdenek Dvorak & Peotr Pavek. (2010) Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids. Drug Metabolism Reviews 42:4, pages 621-635.
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Sayuri Shimazu, Yukiko Kawabata, Akito Inayoshi, Hideyuki Inui, Hitoshi Ashida & Hideo Ohkawa. (2010) Recombinant human AhR-mediated GUS reporter gene assays for PCB congeners in transgenic tobacco plants in comparison with recombinant mouse and guinea pig AhRs. Journal of Environmental Science and Health, Part B 45:8, pages 741-749.
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Articles from other publishers (33)

Yue Chen, Yadong Wang, Yawei Fu, Yulong Yin & Kang Xu. (2023) Modulating AHR function offers exciting therapeutic potential in gut immunity and inflammation. Cell & Bioscience 13:1.
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Katharina Pracht, Jens Wittner, Fritz Kagerer, Hans-Martin Jäck & Wolfgang Schuh. (2023) The intestine: A highly dynamic microenvironment for IgA plasma cells. Frontiers in Immunology 14.
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Stephen Treaster, Joris Deelen, Jacob M. Daane, Joanne Murabito, David Karasik & Matthew P. Harris. (2023) Convergent genomics of longevity in rockfishes highlights the genetics of human life span variation. Science Advances 9:2.
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Yoshiki Tsuboi, Hiroya Yamada, Eiji Munetsuna, Ryosuke Fujii, Mirai Yamazaki, Yoshitaka Ando, Genki Mizuno, Yuji Hattori, Hiroaki Ishikawa, Koji Ohashi, Shuji Hashimoto, Nobuyuki Hamajima & Koji Suzuki. (2022) Intake of vegetables and fruits rich in provitamin A is positively associated with aryl hydrocarbon receptor repressor DNA methylation in a Japanese population. Nutrition Research 107, pages 206-217.
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Tomoya Kitakaze. (2022) Study on Biological Defense Function though Regulation of Drug Metabolism System by Food Factors食品因子の薬物代謝系を介した生体防御機能に関する研究. Nippon Eiyo Shokuryo Gakkaishi 75:6, pages 291-296.
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Nuno R. Coelho, Clara Matos, António B. Pimpão, M. João Correia, Catarina O. Sequeira, Judit Morello, Sofia A. Pereira & Emília C. Monteiro. (2021) AHR canonical pathway: in vivo findings to support novel antihypertensive strategies. Pharmacological Research 165, pages 105407.
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Vanessa Brinkmann, Alfonso Schiavi, Anjumara Shaik, Daniel Rüdiger Puchta & Natascia Ventura. (2020) Dietary and environmental factors have opposite AhR-dependent effects on C. elegans healthspan. Aging 13:1, pages 104-133.
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Iain A. Murray & Gary H. Perdew. (2020) How Ah Receptor Ligand Specificity Became Important in Understanding Its Physiological Function. International Journal of Molecular Sciences 21:24, pages 9614.
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Mohammed Ghiboub, Charlotte M. Verburgt, Bruno Sovran, Marc A. Benninga, Wouter J. de Jonge & Johan E. Van Limbergen. (2020) Nutritional Therapy to Modulate Tryptophan Metabolism and Aryl Hydrocarbon-Receptor Signaling Activation in Human Diseases. Nutrients 12:9, pages 2846.
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Vanessa Brinkmann, Niloofar Ale-Agha, Judith Haendeler & Natascia Ventura. (2020) The Aryl Hydrocarbon Receptor (AhR) in the Aging Process: Another Puzzling Role for This Highly Conserved Transcription Factor. Frontiers in Physiology 10.
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Jonna E. B. Koper, Linda M. P. Loonen, Jerry M. Wells, Antonio Dario Troise, Edoardo Capuano & Vincenzo Fogliano. (2019) Polyphenols and Tryptophan Metabolites Activate the Aryl Hydrocarbon Receptor in an in vitro Model of Colonic Fermentation. Molecular Nutrition & Food Research 63:3, pages 1800722.
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Hitoshi Ashida. (2017) Prevention Mechanism of Lifestyle-related Diseases by Dietary Polyphenols生活習慣病予防に資するポリフェノールの食品機能学的研究. Nippon Eiyo Shokuryo Gakkaishi 70:5, pages 213-223.
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Zhaohui Xue, Dan Li, Wancong Yu, Qian Zhang, Xiaonan Hou, Yulong He & Xiaohong Kou. (2017) Mechanisms and therapeutic prospects of polyphenols as modulators of the aryl hydrocarbon receptor. Food & Function 8:4, pages 1414-1437.
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Marco Gargaro, Matteo Pirro, Giorgia Manni, Antonella De Luca, Teresa Zelante & Francesca Fallarino. 2017. Allergy Prevention and Exacerbation. Allergy Prevention and Exacerbation 167 189 .
Yoshiaki Amakura, Tomoaki Tsutsumi, Morio Yoshimura, Masafumi Nakamura, Hiroshi Handa, Rieko Matsuda, Reiko Teshima & Takahiro Watanabe. (2016) Detection of Aryl Hydrocarbon Receptor Activation by Some Chemicals in Food Using a Reporter Gene Assay. Foods 5:1, pages 15.
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Abby C. Collier, Audrey D. Thévenon, William Goh, Mark Hiraoka & Claire E. Kendal-Wright. (2014) Placental profiling of UGT1A enzyme expression and activity and interactions with preeclampsia at term. European Journal of Drug Metabolism and Pharmacokinetics 40:4, pages 471-480.
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Tianshun Zhang, Yuki Kimura, Songyan Jiang, Kiyonari Harada, Yoko Yamashita & Hitoshi Ashida. (2014) Luteolin modulates expression of drug-metabolizing enzymes through the AhR and Nrf2 pathways in hepatic cells. Archives of Biochemistry and Biophysics 557, pages 36-46.
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Yoshiaki Amakura, Morio Yoshimura, Masashi Takaoka, Haruka Toda, Tomoaki Tsutsumi, Rieko Matsuda, Reiko Teshima, Masafumi Nakamura, Hiroshi Handa & Takashi Yoshida. (2014) Characterization of Natural Aryl Hydrocarbon Receptor Agonists from Cassia Seed and Rosemary. Molecules 19:4, pages 4956-4966.
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Itsuko Fukuda & Hitoshi Ashida. 2014. Polyphenols in Human Health and Disease. Polyphenols in Human Health and Disease 1127 1135 .
Jérôme Ruzzin. 2013. Effects of Persistent and Bioactive Organic Pollutants on Human Health. Effects of Persistent and Bioactive Organic Pollutants on Human Health 130 142 .
Gary N.Y. Chan, Md. Tozammel Hoque & Reina Bendayan. (2013) Role of nuclear receptors in the regulation of drug transporters in the brain. Trends in Pharmacological Sciences 34:7, pages 361-372.
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Erwan Guyot, Aline Chevallier, Robert Barouki & Xavier Coumoul. (2013) The AhR twist: ligand-dependent AhR signaling and pharmaco-toxicological implications. Drug Discovery Today 18:9-10, pages 479-486.
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C Tomkiewicz, L Herry, L-C Bui, C Métayer, M Bourdeloux, R Barouki & X Coumoul. (2012) The aryl hydrocarbon receptor regulates focal adhesion sites through a non-genomic FAK/Src pathway. Oncogene 32:14, pages 1811-1820.
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Felix M. Kluxen, Patrick Diel, Nicola Höfer, Eugenia Becker & Gisela H. Degen. (2012) The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol. Archives of Toxicology 87:4, pages 633-643.
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Jason Matthews & Shaimaa Ahmed. 2013. 1 38 .
Zdenek Dvorak. 2012. Metabolism of Drugs and Other Xenobiotics. Metabolism of Drugs and Other Xenobiotics 223 258 .
Hsi-Kai Wang, Chen-Hao Yeh, Taku Iwamoto, Hideo Satsu, Makoto Shimizu & Mamoru Totsuka. (2012) Dietary Flavonoid Naringenin Induces Regulatory T Cells via an Aryl Hydrocarbon Receptor Mediated Pathway. Journal of Agricultural and Food Chemistry 60:9, pages 2171-2178.
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Jenni Küblbeck, Tuomo Laitinen, Johanna Jyrkkärinne, Timo Rousu, Ari Tolonen, Tobias Abel, Tanja Kortelainen, Jouko Uusitalo, Timo Korjamo, Paavo Honkakoski & Ferdinand Molnár. (2011) Use of comprehensive screening methods to detect selective human CAR activators. Biochemical Pharmacology 82:12, pages 1994-2007.
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Jason Matthews. 2011. Hormone-Disruptive Chemical Contaminants in Food. Hormone-Disruptive Chemical Contaminants in Food 115 135 .
Karina A. Barreiro, María P. Di Yorio, Romina D. Artillo-Guida, Dante A. Paz & Alicia G. Faletti. (2011) Daily treatment with α-naphthoflavone enhances follicular growth and ovulation rate in the rat. Toxicology and Applied Pharmacology 252:1, pages 11-17.
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Aline Chevallier, Linh-Chi Bui & Xavier Coumoul. (2011) Le récepteur de la dioxine : rôle endogène et médiateur de la toxicité de la dioxine. Cahiers de Nutrition et de Diététique 46:2, pages 67-74.
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Iain A. Murray, Colin A. Flaveny, Christopher R. Chiaro, Arun K. Sharma, Rachel S. Tanos, Jennifer C. Schroeder, Shantu G. Amin, William H. Bisson, Siva K. Kolluri & Gary H. Perdew. (2011) Suppression of Cytokine-Mediated Complement Factor Gene Expression through Selective Activation of the Ah Receptor with 3′,4′-Dimethoxy-α-naphthoflavone. Molecular Pharmacology 79:3, pages 508-519.
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Yoshiaki FUJII-KURIYAMA & Kaname KAWAJIRI. (2010) Molecular mechanisms of the physiological functions of the aryl hydrocarbon (dioxin) receptor, a multifunctional regulator that senses and responds to environmental stimuli. Proceedings of the Japan Academy, Series B 86:1, pages 40-53.
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