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Original Articles

Proton therapy with concomitant capecitabine for pancreatic and ampullary cancers is associated with a low incidence of gastrointestinal toxicity

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Pages 498-505 | Received 05 Dec 2012, Accepted 21 Dec 2012, Published online: 12 Mar 2013

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Read on this site (4)

Haruo Fujinaga, Yoshio Sakai, Tatsuya Yamashita, Kuniaki Arai, Takeshi Terashima, Takuya Komura, Akihiro Seki, Kazunori Kawaguchi, Alessandro Nasti, Keiko Yoshida, Takashi Wada, Kazutaka Yamamoto, Kyo Kume, Takashi Hasegawa, Takushi Takata, Masao Honda & Shuichi Kaneko. (2019) Biological characteristics of gene expression features in pancreatic cancer cells induced by proton and X-ray irradiation. International Journal of Radiation Biology 95:5, pages 571-579.
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Gracinda Mondlane, Michael Gubanski, Pehr A. Lind, Ana Ureba & Albert Siegbahn. (2017) Comparison of gastric-cancer radiotherapy performed with volumetric modulated arc therapy or single-field uniform-dose proton therapy. Acta Oncologica 56:6, pages 832-838.
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Bengt Glimelius. (2016) Any progress in pancreatic cancer?. Acta Oncologica 55:3, pages 255-258.
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Francesco Dionisi, Stephen Avery, John N. Lukens, Xuanfeng Ding, John Kralik, Maura Kirk, Robert E. Roses, Maurizio Amichetti, James M. Metz & John P. Plastaras. (2014) Proton therapy in adjuvant treatment of gastric cancer: Planning comparison with advanced x-ray therapy and feasibility report. Acta Oncologica 53:10, pages 1312-1320.
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Articles from other publishers (46)

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Benjamin A. Weinberg, Hongkun Wang, Marcus S. Noel, Aiwu R. He, John L. Marshall, Louis M. Weiner, Thomas M. Fishbein, Nicole E. Hodgins, Emily R. Winslow, Patrick G. Jackson, Juan F. Guerra, Francisco Aguila & Keith R. Unger. (2023) Phase 1 Study of Hypofractionated Proton Beam Radiation Therapy in Adjuvant Pancreatic Cancer (PROTON-PANC). International Journal of Radiation Oncology*Biology*Physics.
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Jacob Eckstein, J. Isabelle Choi, Alicia Lozano, Nitin Ohri, Robert Press, Shaakir Hasan, Rafi Kabarriti, John Chang, James Urbanic, Michael Durci, Nasiruddin Mohammed, Craig Stevens, Henry Tsai, Smith Apisarnthanarax, William Regine, Carlos Vargas, Romaine NicholsJrJr, Joseph Herman, Charles B. SimoneIIII & Arpit Chhabra. (2023) Proton Therapy for Unresectable and Medically Inoperable Locally Advanced Pancreatic Cancer: Results From a Multi-Institutional Prospective Registry. Advances in Radiation Oncology 8:5, pages 101250.
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Sally A. Elkhamisy, Chiara Valentini, Annika Lattermann, Ganesh Radhakrishna, Luise A. Künzel, Steffen Löck & Esther G. C. Troost. (2023) Normo- or Hypo-Fractionated Photon or Proton Radiotherapy in the Management of Locally Advanced Unresectable Pancreatic Cancer: A Systematic Review. Cancers 15:15, pages 3771.
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Max Naumann, Tabea Czempiel, Anna Jana Lößner, Kristin Pape, Elke Beyreuther, Steffen Löck, Stephan Drukewitz, Alexander Hennig, Cläre von Neubeck, Barbara Klink, Mechthild Krause, Doreen William, Daniel E. Stange, Rebecca Bütof & Antje Dietrich. (2022) Combined Systemic Drug Treatment with Proton Therapy: Investigations on Patient-Derived Organoids. Cancers 14:15, pages 3781.
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Jana M. Kobeissi, Charles B. SimoneIIII, Haibo Lin, Lara Hilal & Carla Hajj. (2022) Proton Therapy in the Management of Pancreatic Cancer. Cancers 14:11, pages 2789.
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Ashwathy Susan Mathew & Sapna Nangia. 2022. GI Surgery Annual. GI Surgery Annual 163 183 .
Emma B. Holliday, Eugene J. Koay, Cullen M. Taniguchi & Albert Koong. 2022. Pancreatic Cancer: A Multidisciplinary Approach. Pancreatic Cancer: A Multidisciplinary Approach 153 171 .
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Kyung Su Kim & Hong-Gyun Wu. (2021) Who Will Benefit from Charged-Particle Therapy?. Cancer Research and Treatment 53:3, pages 621-634.
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Sarah Stefanowicz, Waldemar Wlodarczyk, Susanne Frosch, Sebastian Zschaeck & Esther G.C. Troost. (2021) Dose-escalated simultaneously integrated boost photon or proton therapy in pancreatic cancer in an in-silico study: Gastrointestinal organs remain critical. Clinical and Translational Radiation Oncology 27, pages 24-31.
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Waisse Waissi, Anaïs Nicol, Matthieu Jung, Marc Rousseau, Delphine Jarnet, Georges Noel & Hélène Burckel. (2021) Radiosensitizing Pancreatic Cancer with PARP Inhibitor and Gemcitabine: An In Vivo and a Whole-Transcriptome Analysis after Proton or Photon Irradiation. Cancers 13:3, pages 527.
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Tae Hyun Kim, Woo Jin Lee, Sang Myung Woo, Eun Sang Oh, Sang Hee Youn, Hye Young Jang, Sung-Sik Han, Sang-Jae Park, Yang-Gun Suh, Sung Ho Moon, Sang Soo Kim & Dae Yong Kim. (2020) Efficacy and feasibility of proton beam radiotherapy using the simultaneous integrated boost technique for locally advanced pancreatic cancer. Scientific Reports 10:1.
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Vijay P. Raturi, Hidehiro Hojo, Kenji Hotta, Hiromi Baba, Ryo Takahashi, Toshiya Rachi, Naoki Nakamura, Sadamoto Zenda, Atsushi Motegi, Hidenobu Tachibana, Takaki Ariji, Kana Motegi, Masaki Nakamura, Masayuki Okumura, Yasuhiro Hirano & Tetsuo Akimoto. (2020) Radiobiological model-based approach to determine the potential of dose-escalated robust intensity-modulated proton radiotherapy in reducing gastrointestinal toxicity in the treatment of locally advanced unresectable pancreatic cancer of the head. Radiation Oncology 15:1.
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Vijay P. Raturi, Taku Tochinai, Hidehiro Hojo, Toshiya Rachi, Kenji Hotta, Naoki Nakamura, Sadamoto Zenda, Atsushi Motegi, Takaki Ariji, Yasuhiro Hirano, Hiromi Baba, Hajime Ohyoshi, Masaki Nakamura, Masayuki Okumura, Yanping Bei & Tetsuo Akimoto. (2020) Dose–Volume and Radiobiological Model-Based Comparative Evaluation of the Gastrointestinal Toxicity Risk of Photon and Proton Irradiation Plans in Localized Pancreatic Cancer Without Distant Metastasis. Frontiers in Oncology 10.
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Gagan Saini, Rashmi Shukla, Kanika S. Sood, Sujit K. Shukla & Ritu Chandra. (2020) Role of Proton Beam Therapy in Current Day Radiation Oncology Practice. Asian Journal of Oncology 06, pages 097-106.
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Matthew S. Ning, Matthew B. Palmer, Aashish K. Shah, Laura C. Chambers, Laura B. Garlock, Benjamin B. Melson & Steven J. Frank. (2020) Three-Year Results of a Prospective Statewide Insurance Coverage Pilot for Proton Therapy: Stakeholder Collaboration Improves Patient Access to Care. JCO Oncology Practice 16:9, pages e966-e976.
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Walid L. Shaib, Katerina Zakka, Asser A. Shahin, Fares Yared, Jeffrey M. Switchenko, Christina Wu, Mehmet Akce, Olatunji B. Alese, Pretesh R. Patel, Mark Mcdonald & Bassel F. El-Rayes. (2020) Radiation as a Single-Modality Treatment in Localized Pancreatic Cancer. Pancreas 49:6, pages 822-829.
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Shraddha Mahesh Dalwadi, Joseph M. Herman, Prajnan Das & Emma B. Holliday. (2020) Novel Radiotherapy Technologies in the Treatment of Gastrointestinal Malignancies. Hematology/Oncology Clinics of North America 34:1, pages 29-43.
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Mikaela Dell’Oro, Michala Short, Puthenparampil Wilson & Eva Bezak. (2020) Clinical Limitations of Photon, Proton and Carbon Ion Therapy for Pancreatic Cancer. Cancers 12:1, pages 163.
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Adriana C. Gamboa, Rachel M. Lee & Shishir K. Maithel. (2020) The role of radiation for pancreatic adenocarcinoma. Journal of Pancreatology 3:2, pages 72-80.
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Romaine Charles Nichols & Michael Rutenberg. (2019) Optimizing neoadjuvant radiotherapy for resectable and borderline resectable pancreatic cancer using protons. World Journal of Gastrointestinal Surgery 11:7, pages 303-307.
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Yuichi Hiroshima, Nobuyoshi Fukumitsu, Takashi Saito, Haruko Numajiri, Keiko Nemoto Murofushi, Kayoko Ohnishi, Tetsuo Nonaka, Hitoshi Ishikawa, Toshiyuki Okumura & Hideyuki Sakurai. (2019) Concurrent chemoradiotherapy using proton beams for unresectable locally advanced pancreatic cancer. Radiotherapy and Oncology 136, pages 37-43.
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Roberto Pacelli, Mara Caroprese, Giuseppe Palma, Caterina Oliviero, Stefania Clemente, Laura Cella & Manuel Conson. (2019) Technological evolution of radiation treatment: Implications for clinical applications. Seminars in Oncology 46:3, pages 193-201.
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Sarah Stefanowicz, Kristin Stützer, Sebastian Zschaeck, Annika Jakobi & Esther G. C. Troost. (2018) Comparison of different treatment planning approaches for intensity-modulated proton therapy with simultaneous integrated boost for pancreatic cancer. Radiation Oncology 13:1.
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Shahed N. Badiyan, Jason K. Molitoris, Michael D. Chuong, William F. Regine & Adeel Kaiser. (2017) The Role of Radiation Therapy for Pancreatic Cancer in the Adjuvant and Neoadjuvant Settings. Surgical Oncology Clinics of North America 26:3, pages 431-453.
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Lauren M. Rosati, Rachit Kumar & Joseph M. Herman. (2017) Integration of Stereotactic Body Radiation Therapy into the Multidisciplinary Management of Pancreatic Cancer. Seminars in Radiation Oncology 27:3, pages 256-267.
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Vivek Verma, Audrey J. Lazenby, Dandan Zheng, Abhijeet R. Bhirud, Quan P. Ly, Chandrakanth Are, Aaron R. Sasson & Chi Lin. (2017) Dosimetric parameters correlate with duodenal histopathologic damage after stereotactic body radiotherapy for pancreatic cancer: Secondary analysis of a prospective clinical trial. Radiotherapy and Oncology 122:3, pages 464-469.
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Ashwin N. Ram, Lauren M. Rosati & Joseph M. Herman. 2017. Radiation Therapy for Gastrointestinal Cancers. Radiation Therapy for Gastrointestinal Cancers 91 101 .
Jérôme Doyen, Alexander Tuan Falk, Vincent Floquet, Joël Hérault & Jean-Michel Hannoun-Lévi. (2016) Proton beams in cancer treatments: Clinical outcomes and dosimetric comparisons with photon therapy. Cancer Treatment Reviews 43, pages 104-112.
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Daniel H. Ahn, Terence M. Williams, Daniel A. Goldstein, Bassel El-Rayes & Tanios Bekaii-Saab. (2016) Adjuvant therapy for pancreas cancer in an era of value based cancer care. Cancer Treatment Reviews 42, pages 10-17.
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R. Charles NicholsJr.Jr.. 2016. Pancreatic Masses. Pancreatic Masses 237 249 .
Aušra Liubavičiūtė, Jan Aleksander Kraśko, Agata Mlynska, Jelena Lagzdina, Kęstutis Sužiedėlis & Vita Pašukonienė. (2015) Evaluation of low-dose proton beam radiation efficiency in MIA PaCa-2 pancreatic cancer cell line vitality and H2AX formation. Medicina 51:5, pages 302-306.
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Stephanie E. Combs. (2015) Individualized radiotherapy (iRT) concepts for locally advanced pancreatic cancer (LAPC): indications and prognostic factors. Langenbeck's Archives of Surgery 400:7, pages 749-756.
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Suzanne Sachsman, R. Charles NicholsJrJr, Christopher G. Morris, Robert Zaiden, Elizabeth A. Johnson, Ziad Awad, Debashish Bose, Meng Wei Ho, Soon N. Huh, Zuofeng Li, Patrick Kelly & Bradford S. Hoppe. (2014) Proton Therapy and Concomitant Capecitabine for Non-Metastatic Unresectable Pancreatic Adenocarcinoma. International Journal of Particle Therapy 1:3, pages 692-701.
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John P. Plastaras, Francesco Dionisi & Jennifer Y. Wo. (2014) Gastrointestinal Cancer. The Cancer Journal 20:6, pages 378-386.
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Reid F. Thompson, Sonal U. Mayekar, Huifang Zhai, Stefan Both, Smith Apisarnthanarax, James M. Metz, John P. Plastaras & Edgar Ben-Josef. (2014) A dosimetric comparison of proton and photon therapy in unresectable cancers of the head of pancreas. Medical Physics 41:8Part1, pages 081711.
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