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Huan Lan, Ying Zhang, Minqi Fan, Bingxin Wu & Caiyan Wang. (2023) Pregnane X receptor as a therapeutic target for cholestatic liver injury. Drug Metabolism Reviews 55:4, pages 371-387.
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Jie Zhang, Petr Pavek, Rajamanikkam Kamaraj, Li Ren & Tiehua Zhang. (2023) Dietary phytochemicals as modulators of human pregnane X receptor. Critical Reviews in Food Science and Nutrition 63:19, pages 3279-3301.
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Shuhei Fukuno, Katsuhito Nagai, Mai Fujiike, Yuya Sasaki & Hiroki Konishi. (2019) Conflicting alterations in hepatic expression of CYP3A and enzyme kinetics in rats exposed to 5-fluorouracil: relevance to pharmacokinetics of midazolam. Xenobiotica 49:12, pages 1470-1477.
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Guangyao Huang, Liang Yang, Zhaoyan Zhang, Sijia Ren, Xianglin Tang, Wei Zhou, Yuguang Wang, Zengchun Ma, Shan Gao & Yue Gao. (2019) Human PXR-mediated transcriptional activation of CYP3A4 by ‘Fuzi’ extracts. Toxicology Mechanisms and Methods 29:3, pages 155-164.
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Zdenek Dvorak. (2016) Opportunities and challenges in using human hepatocytes in cytochromes P450 induction assays. Expert Opinion on Drug Metabolism & Toxicology 12:2, pages 169-174.
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Yue-Ming Wang, Sergio C Chai, Christopher T Brewer & Taosheng Chen. (2014) Pregnane X receptor and drug-induced liver injury. Expert Opinion on Drug Metabolism & Toxicology 10:11, pages 1521-1532.
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Articles from other publishers (49)
Michael T. Rudd, Peter J. Manley, Barbara Hanney, Zhaoyang Meng, Youheng Shu, Pablo de Leon, Jessica L. Frie, Yongxin Han, Jenny Miu-Chun Wai, Zhi-Qiang Yang, James J. Perkins, Danielle M. Hurzy, Jesse J. Manikowski, Hong Zhu, Christopher J. Bungard, Antonella Converso, Robert S. Meissner, Mali L. Cosden, Ikuo Hayashi, Lei Ma, Julie O’Brien, Victor N. Uebele, Joel B. Schachter, Neetesh Bhandari, Gwendolyn J. Ward, Kerry L. Fillgrove, Bing Lu, Yuexia Liang, David C. Dubost, Vanita Puri, Donnie M. Eddins, Joshua D. Vardigan, Robert E. Drolet, Jonathan T. Kern & Jason M. Uslaner. (2023) Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator. ACS Medicinal Chemistry Letters 14:8, pages 1088-1094.
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Shahzad Kamran, Rukhsana Anwar, Afifa Noor, Muhammad Ihsan Ullah, Alaa A. Bagalagel, Mohammed M. Aldurdunji & Saiqa Ishtiaq. (2023) Metabolic Profiling and Investigation of the Modulatory Effect of Fagonia cretica L. Aerial Parts on Hepatic CYP3A4 and UGT2B7 Enzymes in Streptozotocin—Induced Diabetic Model. Antioxidants 12:1, pages 119.
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Crossref
Thanh T. Lai, David Kuntz & Angela K. Wilson. (2022) Molecular Screening and Toxicity Estimation of 260,000 Perfluoroalkyl and Polyfluoroalkyl Substances (PFASs) through Machine Learning. Journal of Chemical Information and Modeling 62:19, pages 4569-4578.
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Rajamanikkam Kamaraj, Martin Drastik, Jana Maixnerova & Petr Pavek. (2022) Allosteric Antagonism of the Pregnane X Receptor (PXR): Current-State-of-the-Art and Prediction of Novel Allosteric Sites. Cells 11:19, pages 2974.
Crossref
Crossref
Jingjing Huang, Zhaokang Zhang, Chenxia Hao, Yuzhen Qiu, Ruoming Tan, Jialin Liu, Xiaoli Wang, Wanhua Yang & Hongping Qu. (2022) Identifying Drug-Induced Liver Injury Associated With Inflammation-Drug and Drug-Drug Interactions in Pharmacologic Treatments for COVID-19 by Bioinformatics and System Biology Analyses: The Role of Pregnane X Receptor. Frontiers in Pharmacology 13.
Crossref
Crossref
Abidah Parveen, Manal Alhusban, Omer I. Fantoukh, Zulfiqar Ali, Amar G. Chittiboyina, Ikhlas A. Khan & Shabana I. Khan. (2022) Probing PXR activation and modulation of CYP3A4 by Tinospora crispa and Tinospora sinensis. Journal of Ethnopharmacology 291, pages 115159.
Crossref
Crossref
Mingzong Li, Zenon Konteatis, Nelamangala Nagaraja, Yue Chen, Shubao Zhou, Guangning Ma, Stefan Gross, Katya Marjon, Marc L. Hyer, Everton Mandley, Max Lein, Anil K. Padyana, Lei Jin, Shuilong Tong, Rachel Peters, Joshua Murtie, Jeremy Travins, Matthew Medeiros, Peng Liu, Victoria Frank, Evan T. Judd, Scott A. Biller, Kevin M. Marks, Zhihua Sui & Samuel K. Reznik. (2022) Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads. Journal of Medicinal Chemistry 65:6, pages 4600-4615.
Crossref
Crossref
Xin-peng Yao, Ting-ying Jiao, Yi-ming Jiang, Shi-cheng Fan, Ying-yuan Zhao, Xiao Yang, Yue Gao, Fei Li, Yan-ying Zhou, Pan-pan Chen, Min Huang & Hui-chang Bi. (2021) PXR mediates mifepristone-induced hepatomegaly in mice. Acta Pharmacologica Sinica 43:1, pages 146-156.
Crossref
Crossref
Malik Salman Haider, Taufiq Ahmad, Jürgen Groll, Oliver Scherf-Clavel, Matthias Kroiss & Robert Luxenhofer. (2021) The Challenging Pharmacokinetics of Mitotane: An Old Drug in Need of New Packaging. European Journal of Drug Metabolism and Pharmacokinetics 46:5, pages 575-593.
Crossref
Crossref
Lena C. Preiss, Ruoqi Liu, Philip Hewitt, David Thompson, Katrin Georgi, Lassina Badolo, Volker M. Lauschke & Carl Petersson. (2021) Deconvolution of Cytochrome P450 Induction Mechanisms in HepaRG Nuclear Hormone Receptor Knockout Cells. Drug Metabolism and Disposition 49:8, pages 668-678.
Crossref
Crossref
Adrian Hall, Hugues Chanteux, Karelle MénochetMarie Ledecq & Monika-Sarah E. D. Schulze. (2021) Designing Out PXR Activity on Drug Discovery Projects: A Review of Structure-Based Methods, Empirical and Computational Approaches. Journal of Medicinal Chemistry 64:10, pages 6413-6522.
Crossref
Crossref
Nan Zheng, Aili Wei, Tong Wu, Long Long, Haiying Yang, Hua Li & Lili Wang. (2021) Triptolide and atorvastatin synergistically promote hepatotoxicity in cultured hepatocytes and female Sprague-Dawley rats by inhibiting pregnane X receptor-mediated transcriptional activation of CYP3A4. Toxicology Letters 342, pages 85-94.
Crossref
Crossref
Petr Pavek. (2020) 3D Spheroids of Primary Human Hepatocytes: An In Vitro Model That Will Make Pharmacotherapy Safer?. Clinical Pharmacology & Therapeutics 109:5, pages 1186-1188.
Crossref
Crossref
Ran Meng, Xueli Zhang, Haina Wang, Danlu Zhang & Xin Zhao. (2021) Different Inductive Effects of Praziquantel Racemate and its Enantiomers on the Enzyme CYP3A4 Mediated by Pregnane X Receptor and its Variants. Current Drug Metabolism 22:3, pages 232-239.
Crossref
Crossref
Jun-ichi Kobayashi, Hideaki Hirasawa, Yoshikazu Fujimori, Osamu Nakanishi, Noboru Kamada, Tetsuya Ikeda, Akitoshi Yamamoto & Hiroki Kanbe. (2021) Identification of N-acyl-N-indanyl-α-phenylglycinamides as selective TRPM8 antagonists designed to mitigate the risk of adverse effects. Bioorganic & Medicinal Chemistry 30, pages 115903.
Crossref
Crossref
Sergio C. Chai & Taosheng Chen. 2021. Nuclear Receptors. Nuclear Receptors
179
198
.
Peter Illés, Kristýna Krasulová, Barbora Vyhlídalová, Karolína Poulíková, Adéla Marcalíková, Petra Pečinková, Natália Sirotová, Radim Vrzal, Sridhar Mani & Zdeněk Dvořák. (2020) Indole microbial intestinal metabolites expand the repertoire of ligands and agonists of the human pregnane X receptor. Toxicology Letters 334, pages 87-93.
Crossref
Crossref
Yueping Zhang, Cliff Chen, Shen-Jue Chen, Xue-Qing Chen, David J. Shuster, Pawel D. Puszczalo, R. Marcus Fancher, Zheng Yang, Michael Sinz & Hong Shen. (2020) Absence of OATP1B (Organic Anion–Transporting Polypeptide) Induction by Rifampin in Cynomolgus Monkeys: Determination Using the Endogenous OATP1B Marker Coproporphyrin and Tissue Gene Expression. Journal of Pharmacology and Experimental Therapeutics 375:1, pages 139-151.
Crossref
Crossref
Dvora Izgelov, Abraham J. Domb & Amnon Hoffman. (2020) The effect of piperine on oral absorption of cannabidiol following acute vs. chronic administration. European Journal of Pharmaceutical Sciences 148, pages 105313.
Crossref
Crossref
Michael J. Bower, Alex M. Aronov, Thomas Cleveland, Niresh Hariparsad, Georgia B. McGaughey, Daniel R. McMasters, Xiaodan Zhang & Brian Goldman. (2020) Smallest Maximum Intramolecular Distance: A Novel Method to Mitigate Pregnane Xenobiotic Receptor Activation. Journal of Chemical Information and Modeling 60:4, pages 2091-2099.
Crossref
Crossref
Beyza Bulutoglu, Camilo Rey-Bedón, Safak Mert, Lipeng Tian, Yoon-Young Jang, Martin L. Yarmush & O. Berk Usta. (2020) A comparison of hepato-cellular in vitro platforms to study CYP3A4 induction. PLOS ONE 15:2, pages e0229106.
Crossref
Crossref
Jaleh A. Abedini, Sakshi Handa, Stephen Edwards, Brian Chorley & Hisham El-Masri. (2019) Identification of differentially expressed genes and networks related to hepatic lipid dysfunction. Toxicology and Applied Pharmacology 382, pages 114757.
Crossref
Crossref
Yoann Cazaubon, Yohann Talineau, Catherine Feliu, Céline Konecki, Jennifer Russello, Olivier Mathieu & Zoubir Djerada. (2019) Population Pharmacokinetics Modelling and Simulation of Mitotane in Patients with Adrenocortical Carcinoma: An Individualized Dose Regimen to Target All Patients at Three Months?. Pharmaceutics 11:11, pages 566.
Crossref
Crossref
Fengling Wang, Huihui Wang, Yifan Wu, Lei Wang, Ling Zhang, Xi Ye, Daiyin Peng & Weidong Chen. (2019) Activation of Pregnane X Receptor–Cytochrome P450s Axis: A Possible Reason for the Enhanced Accelerated Blood Clearance Phenomenon of PEGylated Liposomes In Vivo. Drug Metabolism and Disposition 47:8, pages 785-793.
Crossref
Crossref
Hang Zeng, Yiming Lin, Jiande Gong, Sisi Lin, Jianguo Gao, Chunxiao Li, Zemin Feng, Hong Zhang, Jie Zhang, Youming Li & Chaohui Yu. (2019) CYP3A suppression during diet-induced nonalcoholic fatty liver disease is independent of PXR regulation. Chemico-Biological Interactions.
Crossref
Crossref
U Arshad, M Taubert, M Kurlbaum, S Frechen, S Herterich, F Megerle, S Hamacher, M Fassnacht, U Fuhr & M Kroiss. (2018) Enzyme autoinduction by mitotane supported by population pharmacokinetic modeling in a large cohort of adrenocortical carcinoma patients. European Journal of Endocrinology, pages 287-297.
Crossref
Crossref
Seema Negi, Shashi Kala Singh, Sanjay Kumar, Subodh Kumar & Rakesh K. Tyagi. (2018) Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules. Toxicology in Vitro 52, pages 222-234.
Crossref
Crossref
Katalin Monostory. 2018. Organ Donation and Transplantation - Current Status and Future Challenges. Organ Donation and Transplantation - Current Status and Future Challenges.
Fengling Wang, Yifan Wu, Xiaoting Xie, Jing Sun & Weidong Chen. (2018) Essential role of nuclear receptors for the evaluation of the benefits of bioactive herbal extracts on liver function. Biomedicine & Pharmacotherapy 99, pages 798-809.
Crossref
Crossref
Sora Choi, Prince Neequaye, Samuel W. French, Frank J. Gonzalez & Maxwell A. Gyamfi. (2018) Pregnane X receptor promotes ethanol-induced hepatosteatosis in mice. Journal of Biological Chemistry 293:1, pages 1-17.
Crossref
Crossref
Hsiao-Yun Chang, Chao-Jung Chen, Wei-Chih Ma, Wai-Kok Cheng, Yen-Ning Lin, Ying-Ray Lee, Jih-Jung Chen & Yun-Ping Lim. (2017) Modulation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation by ursolic acid (UA) attenuates rifampin-isoniazid cytotoxicity. Phytomedicine 36, pages 37-49.
Crossref
Crossref
Jan Dusek, Alejandro Carazo, Frantisek Trejtnar, Lucie Hyrsova, Ondřej Holas, Tomas Smutny, Stanislav Micuda & Petr Pavek. (2017) Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation. Food and Chemical Toxicology 109, pages 130-142.
Crossref
Crossref
Wenwei Lin, Yue-Ming Wang, Sergio C. Chai, Lili Lv, Jie Zheng, Jing Wu, Qijun Zhang, Yong-Dong Wang, Patrick R. Griffin & Taosheng Chen. (2017) SPA70 is a potent antagonist of human pregnane X receptor. Nature Communications 8:1.
Crossref
Crossref
Nao Torimoto-Katori, Ruili Huang, Harutoshi Kato, Rikiya Ohashi & Menghang Xia. (2017) In Silico Prediction of hPXR Activators Using Structure-Based Pharmacophore Modeling. Journal of Pharmaceutical Sciences 106:7, pages 1752-1759.
Crossref
Crossref
Stephanie Piekos, Chad Pope, Austin Ferrara & Xiao-bo Zhong. (2017) Impact of Drug Treatment at Neonatal Ages on Variability of Drug Metabolism and Drug-Drug Interactions in Adult Life. Current Pharmacology Reports 3:1, pages 1-9.
Crossref
Crossref
Grażyna Kubiak-Tomaszewska, Jan Pachecka, Jacek Łukaszkiewicz & Piotr Tomaszewski. (2016) RECEPTOROWE MECHANIZMY REGULACJI METABOLIZMU KWASÓW ŻÓŁCIOWYCH I KSENOBIOTYKÓW. ZNACZENIE EKSPRESJI CYP3A4 DLA BEZPIECZEŃSTWA I SKUTECZNOŚCI FARMAKOTERAPII. Prospects in Pharmaceutical Sciences 14:9, pages 57-63.
Crossref
Crossref
Beth Williamson, Mathias Lorbeer, Michael D. Mitchell, Timothy G. Brayman & Robert J. Riley. (2016)
Evaluation of a novel PXR-knockout in HepaRG
™
cells
. Pharmacology Research & Perspectives 4:5, pages e00264.
Crossref
Crossref
Manjul Rana, Suneeta Devi, Samudrala Gourinath, Ravinder Goswami & Rakesh K. Tyagi. (2016) A comprehensive analysis and functional characterization of naturally occurring non-synonymous variants of nuclear receptor PXR. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1859:9, pages 1183-1197.
Crossref
Crossref
Sergio C. Chai, Milu T. Cherian, Yue-Ming Wang & Taosheng Chen. (2016) Small-molecule modulators of PXR and CAR. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1859:9, pages 1141-1154.
Crossref
Crossref
Jiuda Zhao, Zhenzhong Bai, Fan Feng, Erlin Song, Feng Du, Junhui Zhao, Guoshuang Shen, Faxiang Ji, Guoyuan Li, Xinfu Ma, Xingyi Hang & Binghe Xu. (2016) Cross-talk between EPAS-1/HIF-2α and PXR signaling pathway regulates multi-drug resistance of stomach cancer cell. The International Journal of Biochemistry & Cell Biology 72, pages 73-88.
Crossref
Crossref
Y-J Xue, Matthew Hoffmann, Zeen Tong, Xinqun (Irene) Wu, Martha Vallejo, Brian Melo, Ying Ye, Michael Thomas, Yong Liu, Daniel Weiss & Sekhar Surapaneni. (2016) Use of 4β-hydroxycholesterol in animal and human plasma samples as a biomarker for CYP3A induction. Bioanalysis 8:3, pages 215-228.
Crossref
Crossref
Yue-Ming Wang, Sergio C. Chai, Wenwei Lin, Xiaojuan Chai, Ayesha Elias, Jing Wu, Su Sien Ong, Satyanarayana R. Pondugula, Jordan A. Beard, Erin G. Schuetz, Su Zeng, Wen Xie & Taosheng Chen. (2015) Serine 350 of human pregnane X receptor is crucial for its heterodimerization with retinoid X receptor alpha and transactivation of target genes in vitro and in vivo. Biochemical Pharmacology 96:4, pages 357-368.
Crossref
Crossref
Javed A. Khan, Daniel M. Camac, Simon Low, Andrew J. Tebben, David L. Wensel, Martin C. Wright, Julie Su, Victoria Jenny, Ruchira Das Gupta, Max Ruzanov, Katie A. Russo, Aneka Bell, Yongmi An, James W. Bryson, Mian Gao, Pallavi Gambhire, Eric T. Baldwin, Daniel Gardner, Cullen L. Cavallaro, John V. Duncia & John HynesJr.Jr.. (2015) Developing Adnectins That Target SRC Co-Activator Binding to PXR: A Structural Approach toward Understanding Promiscuity of PXR. Journal of Molecular Biology 427:4, pages 924-942.
Crossref
Crossref
Stephen S. Ferguson & Jessica A. Bonzo. 2014. Drug Metabolism Prediction. Drug Metabolism Prediction
441
484
.
Žiga Hodnik, Lucija Peterlin Mašič, Tihomir Tomašić, Domen Smodiš, Claudio D’Amore, Stefano Fiorucci & Danijel Kikelj. (2014) Bazedoxifene-Scaffold-Based Mimetics of Solomonsterols A and B as Novel Pregnane X Receptor Antagonists. Journal of Medicinal Chemistry 57:11, pages 4819-4833.
Crossref
Crossref
Stalin Selvaraj, Ramya Ramanathan, Varshini Vasudevaraja, Kalpoondi Sekar Rajan, Sridharan Krishnaswamy, Brindha Pemiah, Swaminathan Sethuraman, Vigneshwar Ramakrishnan & Uma Maheswari Krishnan. (2014) Transcriptional regulation of the pregnane-X receptor by the Ayurvedic formulation Chandraprabha Vati. RSC Adv. 4:110, pages 64967-64976.
Crossref
Crossref
Vijay Rathod, Sumit Jain, Prajwal Nandekar & Abhay T. Sangamwar. (2014) Human pregnane X receptor: a novel target for anticancer drug development. Drug Discovery Today 19:1, pages 63-70.
Crossref
Crossref
Ling Huang, Min Huang, Yu-Hua Li, Rui-Ming Li, Yu Zeng, Shao-Yi Kuang, Li Zhang, Yi-Tao Wang & Hui-Chang Bi. (2013) Up-regulatation of CYP3A expression through pregnent X receptor by praeruptorin D isolated from Peucedanum praeruptorum Dunn. Journal of Ethnopharmacology 148:2, pages 596-602.
Crossref
Crossref
Martin Šíma, I. Netíková & O. Slanař. (2013) Pregnane Xenobiotic Receptors and Their Effect on Drug Elimination from the Organism. Prague Medical Report 114:4, pages 205-213.
Crossref
Crossref