749
Views
16
CrossRef citations to date
0
Altmetric
Review Article

Substrate selectivity of human intestinal UDP-glucuronosyltransferases (UGTs): in silico and in vitro insights

, , &
Pages 231-252 | Received 27 Sep 2012, Accepted 14 Jan 2013, Published online: 06 Mar 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Xin Liu, Yun-Feng Cao, Pei-Pei Dong, Liang-Liang Zhu, Zhenying Zhao, Xue Wu, Zhi-Wei Fu, Chun-Ting Huang, Zhong-Ze Fang & Hong-Zhi Sun. (2017) The inhibition of UDP-glucuronosyltransferases (UGTs) by vitamin A. Xenobiotica 47:5, pages 376-381.
Read now
Satya Prakash Tripathi, Rameshwar Prajapati, Neha Verma & Abhay T. Sangamwar. (2016) Predicting substrate selectivity between UGT1A9 and UGT1A10 using molecular modelling and molecular dynamics approach. Molecular Simulation 42:4, pages 270-288.
Read now

Articles from other publishers (14)

Michael J. Osborne, Anamika Sulekha, Biljana Culjkovic-Kraljacic, Jadwiga Gasiorek, Edward Ruediger, Eric Jolicouer, Anne Marinier, Sarit Assouline & Katherine L.B. Borden. (2023) Medicinal chemistry and NMR driven discovery of novel UDP-glucuronsyltransferase 1A inhibitors that overcome therapeutic resistance in cells. Journal of Molecular Biology, pages 168378.
Crossref
Zhe Wang, Lili Jiang, Xiaoyu Wang, Hang Yin, Zhen Wang, Xin Lv & Yong Liu. (2022) Cabozantinib Carries the Risk of Drug-Drug Interactions via Inhibition of UDPglucuronosyltransferase (UGT) 1A9 . Current Drug Metabolism 23:11, pages 912-919.
Crossref
Lianxia Guo, Dong Dong, Tianpeng Zhang & Baojian Wu. 2020. Circadian Pharmacokinetics. Circadian Pharmacokinetics 113 129 .
Yutaka Takaoka, Atsuko Takeuchi, Aki Sugano, Kenji Miura, Mika Ohta, Takashi Suzuki, Daisuke Kobayashi, Takuji Kimura, Juichi Sato, Nobutaro Ban, Hisahide Nishio & Toshiyuki Sakaeda. (2019) Establishment of the experimental procedure for prediction of conjugation capacity in mutant UGT1A1. PLOS ONE 14:11, pages e0225244.
Crossref
Michael J. Osborne, Luciana Coutinho de Oliveira, Laurent Volpon, Hiba Ahmad Zahreddine & Katherine L.B. Borden. (2019) Overcoming Drug Resistance through the Development of Selective Inhibitors of UDP-Glucuronosyltransferase Enzymes. Journal of Molecular Biology 431:2, pages 258-272.
Crossref
Thomas J. Flynn & Sanah N. Vohra. (2018) Simultaneous determination of intestinal permeability and potential drug interactions of complex mixtures using Caco-2 cells and high-resolution mass spectrometry: Studies with Rauwolfia serpentina extract. Chemico-Biological Interactions 290, pages 37-43.
Crossref
Laura Righetti, Marie Fenclova, Luca Dellafiora, Jana Hajslova, Milena Stranska-Zachariasova & Chiara Dall'Asta. (2018) High resolution-ion mobility mass spectrometry as an additional powerful tool for structural characterization of mycotoxin metabolites. Food Chemistry 245, pages 768-774.
Crossref
Melissa Brazier-Hicks, Markus Gershater, David Dixon & Robert Edwards. (2018) Substrate specificity and safener inducibility of the plant UDP-glucose-dependent family 1 glycosyltransferase super-family. Plant Biotechnology Journal 16:1, pages 337-348.
Crossref
Florent Di Meo, Gabin Fabre, Karel Berka, Tahani Ossman, Benjamin Chantemargue, Markéta Paloncýová, Pierre Marquet, Michal Otyepka & Patrick Trouillas. (2016) In silico pharmacology: Drug membrane partitioning and crossing. Pharmacological Research 111, pages 471-486.
Crossref
Qingping Wang & Meng Li. 2016. Drug Delivery. Drug Delivery 164 185 .
Shupeng Yang, Marthe De Boevre, Huiyan Zhang, Karl De Ruyck, Feifei Sun, Zhanhui Wang, Xingyuan Cao, Jianzhong Shen, Sarah De Saeger & Suxia Zhang. (2015) Unraveling the in vitro and in vivo metabolism of diacetoxyscirpenol in various animal species and human using ultrahigh-performance liquid chromatography-quadrupole/time-of-flight hybrid mass spectrometry. Analytical and Bioanalytical Chemistry 407:28, pages 8571-8583.
Crossref
Li Jiang, Si-Cheng Liang, Chao Wang, Guang-Bo Ge, Xiao-Kui Huo, Xiao-Yi Qi, Sa Deng, Ke-Xin Liu & Xiao-Chi Ma. (2015) Identifying and applying a highly selective probe to simultaneously determine the O-glucuronidation activity of human UGT1A3 and UGT1A4. Scientific Reports 5:1.
Crossref
Bin Guo, Zhongze Fang, Lu Yang, Ling Xiao, Yangliu Xia, Frank J. Gonzalez, Liangliang Zhu, Yunfeng Cao, Guangbo Ge, Ling Yang & Hongzhi Sun. (2015) Tissue and species differences in the glucuronidation of glabridin with UDP-glucuronosyltransferases. Chemico-Biological Interactions 231, pages 90-97.
Crossref
Brandon T. Gufford, Gang Chen, Philip Lazarus, Tyler N. Graf, Nicholas H. Oberlies & Mary F. Paine. (2014) Identification of Diet-Derived Constituents as Potent Inhibitors of Intestinal Glucuronidation. Drug Metabolism and Disposition 42:10, pages 1675-1683.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.