Abstract
Owing to deprived hydrophilicity, Artemisinin (ART) is known as Class II biopharmaceutical (BCS). The goal of the existing endeavor is to formulate ART self-nanoemulsifying drug delivery systems (ART-SNEDDS) that will increase its solubility in water. Thus, excipients were screened in pre-formulation experiments for solubility and emulsification effectiveness. Moreover, blends of the oil soy bean, surfactant tween 80 and co-surfactant soy lecithin were used to create pseudo ternary phase diagrams at different ratios. Further, the prepared ART-SNEDDS were evaluated visually, for thermodynamic stability, time to self nano-emulsify, the impact of dilution and pH, % transmittance, droplet size, poly dispersity index (PDI), surface morphology studies, zeta potential, in-vitro release rate, and for oral pharmacokinetic studies. The ART-SNEDDS were prepared to increase the quantity of loaded ART into the formulation. Nevertheless, in-vitro dissolution studies of the ART-SNEDDS formulation demonstrated an increased dissolution with improved solubility. It was found through oral bio-availability experiments in rats that there was an improvement in rate of absorption as well. As a result, a formulation to increase the drug’s solubility and perhaps bioavailability was developed.
Authors contribution
Sravani Karri: Concept, Experimental work, writing of manuscript, editing of the manuscript. Sanjay Sharma: Concept, editing, of the manuscript. Ginpreet Kaur: Concept, editing, of the manuscript.
Disclosure statement
The authors report there are no competing interests to declare.