Evaluation of psoriasis patients with long-term topical corticosteroids for their risk of developing adrenal insufficiency, Cushing’s syndrome and osteoporosis

Figures & data

Table 1. Distribution of the sample groups according to age, PASI, duration of illness, weekly amount.

	Group 1 (n = 24)	Group 2 (n = 25)
Age	54	46.38
Duration of illness (years)	14.58	16.86
Mean PASI at presentation	12.17	12.44
Weekly amount of topical steroid use (g)	62.29	87
Active substance of topical steroid used	number of patients	number of patients
Mometasone furoate lotion (class 4)	6	0
Mometasone furoate pomade (class 2)	13	0
Betamethasone dipropionate ointment (class 2)	5	0
Clobetasol propionate (class 1)	0	25

Table 2. ACTH, cortisol and DEXA results.

	Group 1 (n = 24)		Group 2 (n = 25)
Screening for ACTH /adrenal insufficiency	n	%	n	%
above 10 pg/ml	23	95.8	23	92
below 10 pg/ml	1	4.2	2	8
Screening for cortisol/adrenal insufficiency	n	%	n	%
above 6.7 µg/dL	23	95.8	21	84
below 6.7 µg/dL	1	4.2	4	16
DEXA femoral neck according to the T score	n	%	n	%
normal	15	62.5	17	68
osteopenia	9	37.5	6	24
osteoporosis	0	0	2	8
DEXA L1-L4 according to the T Score	n	%	n	%
normal	13	54.1	11	44
osteopenia	8	33.3	8	32
osteoporosis	3	12.5	6	24

Table 3. Sociodemographic and clinical characteristics, ACTH, cortisol values and time of axis recovery of five patients screened for adrenal insufficiency.

Patient	Group	Age	Gender	ACTH	Cortisol	Axis recovery time (month)	Duration of steroid use (month)	Amount of steroid use (g/week)	PASI
1.	1	88	M	10	6.12	–	48	100	18
2.	2	53	M	15	1.03	1	24	150	6.4
3.	2	37	M	<5	0.01	2	60	50	36.9
4.	2	58	M	26.9	0.23	2	36	100	38
5.	2	56	F	<5	0.05	3	500	350	10

M: male F: female.

Table 4. Sociodemographic and clinical characteristics and DEXA scores of patients diagnosed with osteoporosis.

Patient	Group	Gender (age)	Smoking	DEXA femoral T-score	DEXA L1-L4 T score	DEXA femoral Z-score	DEXA L1-L4 Z score	duration of steroid use (month)	the amount of steroid use (g/week)
1.	1	M (71)	–	−0.5	−2.6	−0.7	−2	48	90
2.	1	M (37)	–	−1.1	−2.7	−0.9	−2.7	12	50
3.	1	F (54)	–	−1.2	−3	−0.8	−3	48	60
4.	2	M (53)	–	−1.5	−2.7	−1.1	−1.8	120	50
5.	2	M (31)	+9 packages/year	−1.1	−2.6	−0.7	−2	150	50
6.	2	M (50)	+5 packages/year	−1.4	−3.2	−1.1	−2.7	120	50
7.	2	F (28)	–	0.5	−2.5	0.6	−2.5	12	50
8.	2	M (79)	–	−1.4	−3.5	−1.5	−2.5	3	50
9.	2	M (68)	–	−2.6	−2.7	−2	−0.7	130	150
10.	2	F (56)	–	−2.7	−2.3	−2.1	−2	500	350
11.	2	M (37)	+10 packages/year	−0.9	−0.2	−0.7	−2.1	60	50

Data availability statement

Data openly available in a public repository that issues datasets with DOIs.