Apremilast for the treatment of pustular psoriasis induced by neoadjuvant ifosfamide + etoposide chemotherapy for Ewing Sarcoma: a case report

Figures & data

Figure 1. Erythematous plaques covered by multiple pustules in a 33-year-old female (Figure 1(a,b)). Histopathological picture of an incisional biopsy from a plaque on the back. Section of the skin characterized by epidermal hyperplasia, orto-parakeratosis, mixed inflammatory infiltrate in the dermis (Figure 1(c)), and micro pustules (Figure 1(d)). (c) Hematoxylin and Eosin stain, ×10 magnification; (d) Hematoxylin and Eosin stain, ×20 magnification

Table 1. Evaluation of causality relation according to Naranjo algorithm.

1. Are there previous conclusive reports on this reaction?	0
2. Did the adverse event appear after the suspected drug was administered?	+2
3. Did the adverse event improve when the drug was discontinued or a specific antagonist was administered?	+1
4. Did the adverse event reappear when the drug was readministered?	+2
5. Are there alternative causes that could on their own have caused the reaction?	−1
6. Did the reaction reappear when a placebo was given?	0
7. Was the drug detected in blood or other fluids in concentrations known to be toxic?	0
8. Was the reaction more severe when the dose was increased or less severe when the dose was decreased?	0
9. Did the patient have a similar reaction to the same or similar drugs in any previous exposure?	+1
10. Was the adverse event confirmed by any objective evidence?	+1
Total Score	6

Figure 2. Almost complete remission of pustular psoriasis after 4 weeks of follow-up.

Data availability statement

Data available on request from the authors.