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Journal of Dermatological Treatment Volume 35, 2024 - Issue 1
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Case Report

Successful treatment of recalcitrant generalized pustular psoriasis of pregnancy with spesolimab

Chenxin Yanga Department of Dermatology, Peking University First Hospital, Beijing, China;b National Clinical Research Center for Skin and Immune Diseases, Beijing, China;c Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, ChinaView further author information
,
Yang Wanga Department of Dermatology, Peking University First Hospital, Beijing, China;b National Clinical Research Center for Skin and Immune Diseases, Beijing, China;c Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, ChinaView further author information
,
Ruoyu Lia Department of Dermatology, Peking University First Hospital, Beijing, China;b National Clinical Research Center for Skin and Immune Diseases, Beijing, China;c Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, ChinaView further author information
,
Ping Tua Department of Dermatology, Peking University First Hospital, Beijing, China;b National Clinical Research Center for Skin and Immune Diseases, Beijing, China;c Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, ChinaView further author information
&
Ruojun Wanga Department of Dermatology, Peking University First Hospital, Beijing, China;b National Clinical Research Center for Skin and Immune Diseases, Beijing, China;c Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, ChinaCorrespondence[email protected]
View further author information
Article: 2334791 | Received 15 Feb 2024, Accepted 20 Mar 2024, Published online: 02 Apr 2024

Figures & data

Figure 1. (A) Generalized edematous erythema with numerous pustules over the body. (B) 48h after application of spesolimab, the lesions were significantly improved.

Figure 1. (A) Generalized edematous erythema with numerous pustules over the body. (B) 48h after application of spesolimab, the lesions were significantly improved.

Figure 2. A histopathological examination of a punch biopsy specimen from the arm shows subcorneal pustules with epidermal spongiosis (hematoxylin-eosin; original magnification ×100).

Figure 2. A histopathological examination of a punch biopsy specimen from the arm shows subcorneal pustules with epidermal spongiosis (hematoxylin-eosin; original magnification ×100).

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