Analgesic Effects of Aqueous Extracts of the Leaves of Bryophyllum pinnatum.

Figures & data

Table 1.. Analgesic activity (hot-plate method) of the aqueous extract of B. pinnatum..

			After-treatment reaction time (ATRT) (s) (upper values)and % increase of ATRT against PTRT (lower values)^a.
Animalgroup	Drug and dose	Pretreatmentreaction time(PTRT) (s)	30 min	60 min	90 min	120 min	150 min
1	Extract 100 mg/kg	16.5 ± 2.0	20.3 ± 1.6 (23.0)	26.1 ± 1.0 (58.2)	31.1 ± 1.6 (88.5)	25.1 ± 2.0 (52.1)	20.0 ± 1.2 (21.2)
2	Extract 200 mg/kg	16.0 ± 1.2	23.2 ± 1.3 (45.0)	32.7 ± 1.0 (104.4)	44.0 ± 1.9 (175.0)	33.0 ± 2.4 (106.3)	24.3 ± 1.3 (51.9)
3	Extract 300 mg/kg	18.6 ± 1.1	27.2 ± 1.5 (46.2)	38.6 ± 1.0 (107.5)	54.6 ± 1.2 (193.5)	48.2 ± 1.0 (159.1)	36.0 ± 1.6 (93.5)
4	Aspirin 100 mg/kg	17.3 ± 1.13	29.4 ± 1.3 (70.0)	39.2 ± 1.2 (126.6)	53.0 ± 0.8 (206.4)	47.2 ± 2.0 (172.8)	35.2 ± 1.9 (105.5)
5	Normal saline 25 ml/kg	16.7 ± 1.0	16.9 ± 1.2 (1.2)	17.0 ± 1.7 (1.8)	17.3 ± 3.4 (3.6)	17.5 ± 2.6 (7.8)	17.0 ± 1.6 (1.2)

^a.The upper values represent the mean analgesic time in seconds±SEM and the lower ones (in parentheses) represent the percent increase of ATRT against PTRT (n = 6).

Table 2.. Analgesic effects of aqueous extract of B. pinnatum. and acetylsalicylic acid against writhing test in mice and carrageenan-induced rat paw edema.

			Percentage inhibition
	Treatment group	Dose,mg/kg (p.o)	Writhing	Rat paw edema
A.	Aqueous extract	100	60	18
B.	Aqueous extract	200	75	15
C.	Aqueous extract	300	80	18
D.	Acetylsalicylic acid	100	80	54
E.	Normal saline	25 ml/kg	0	0