Antiulcer Effects of the Aqueous and Organic Extracts of the Stem Bark of Anthocleista vogelii. in Rats

Figures & data

Table 1 pH of the extract solutions.

Extract solution	pH of the extract solution
Aqueous extract (50 mg/ml)	4.13
Methanol extract (50 mg/ml)	3.11

Table 2 Effects of the stem bark aqueous and organic extracts of Anthocleista vogelii. on HCl/ethanol–induced gastric lesions in rats.

Treatment	n	Dose (mg/kg)	US area (mm^2)	Ulcer index	% US	% I	Mucus wet weight(mg)
Distilled water	6	—	132.61 ± 24.70	5.49 ± 0.98	22.02	—	51 ± 0.46
DMSO (3%)	6	—	125.50 ± 7.44	5.01 ± 0.50	20.89	—	51 ± 0.48
Cimetidine	6	12	92.82 ± 16.62	5.57 ± 0.76	13.78	29.84	61 ± 0.83
Sucralfate	6	50	36.87 ± 25.14^b.	3.46 ± 1.75	04.82	72.20	78 ± 0.96^b.
	6	100	25.21 ± 4.26^b.	3.72 ± 0.38^a.	03.80	80.99	85 ± 1.20^b.
Aqueous extract	6	125	82.37 ± 11.53^b.	5.09 ± 0.46	12.96	37.89	61 ± 0.77
	6	250	32.79 ± 15.40^b.	3.42 ± 0.37^a.	04.25	75.27	95 ± 0.64^b.
	6	500	16.04 ± 5.44^b.	3.08 ± 0.56^b.	02.58	87.91	96 ± 0.74^b.
Hexane extract	6	250	49.05 ± 10.36^b.	4.18 ± 0.64	07.02	60.92	77 ± 0.82
	6	500	51.20 ± 14.90^a.	4.24 ± 0.61	07.49	59.20	81 ± 1.27
Acetone extract	6	250	46.45 ± 13.49^b.	3.58 ± 0.36	05.74	62.99	92 ± 0.83
	6	500	30.67 ± 13.70^b.	3.93 ± 1.00	03.40	75.56	99 ± 0.78
Methanol extract	6	125	36.43 ± 10.29^b.	4.18 ± 0.45	06.28	72.53	58 ± 0.48^a.
	6	250	19.88 ± 6.17^b.	3.39 ± 0.18^b.	02.79	85.00	96 ± 0.98^b.
	6	500	0.00 ± 0.00^b.	0.00 ± 0.00^b.	00.00	100	100 ± 0.60^b.

n, number of rats per group; I, inhibition; US, ulcer surface.

^a.p ≤ 0.05

^b.p ≤ 0.01, statistically significant relative to control.

Table 3 Effects of the stem bark aqueous and methanol extracts of Anthocleista vogelii. on gastric lesions induced by indomethacin.

Treatment	n	Dose(mg/kg)	US area (mm^2)	Ulcer index	% US	% I	Mucus wet weight(mg)
Control	6	—	82.97 ± 5.08	3.64 ± 0.68	13.96	—	57 ± 0.64
Sucralfate	6	50	14.75 ± 3.39^b.	3.16 ± 0.61	02.43	82.22	59 ± 0.40
Aqueous extract	6	125	70.09 ± 13.83	3.63 ± 0.53	09.82	16.41	52 ± 0.35
	6	250	39.21 ± 13.34^b.	3.22 ± 0.53	06.43	52.74	55 ± 0.97
	6	500	17.74 ± 3.04^b.	3.22 ± 0.33	03.06	78.62	64 ± 0.54
Methanol extract	6	125	50.92 ± 12.66^b.	3.62 ± 0.53	07.50	38.62	56 ± 0.34
	6	250	22.33 ± 9.25^b.	2.63 ± 0.49^a.	03.66	73.09	67 ± 0.53
	6	500	0.00 ± 0.00^b.	0.00 ± 0.00^b.	00.00	100	89 ± 0.10

n, number of rats per group; I, inhibition; US, ulcer surface.

^a.p ≤ 0.05

^b.p ≤ 0.01, statistically significant relative to control.

Table 4 Effects of the stem bark aqueous and methanol extracts of Anthocleista vogelii. on pylorus ligation ulceration.

Treatment	n	Dose (mg/kg)	US area (mm^2)	Ulcer index	% US	% I	Gastric juice (ml)	Gastric pH	Gastric acidity (meq/l)	Mucus wet weight (mg)
Control	6	—	64.63 ± 5.24	3.91 ± 1.16	16.62	—	5.71 ± 0.71	1.83 ± 0.66	134.17 ± 2.04	56 ± 0.69
Cimetidine	6	12	41.45 ± 8.43^b.	2.33 ± 0.34^a.	06.52	35.87	5.53 ± 0.79	1.58 ± 0.93	89.95 ± 19.71^b.	63 ± 0.60
Maalox	6	50	24.15 ± 2.88^b.	2.72 ± 0.28	03.71	62.63	6.30 ± 0.63^b.	0.97 ± 0.34^a.	115.55 ± 26.13	64 ± 0.66
Aqueous extract	6	125	64.66 ± 6.02	2.86 ± 0.32	11.87	0.00	4.87 ± 1.46	1.17 ± 0.17	105.90 ± 7.40^b.	53 ± 0.42
	6	250	53.74 ± 5.65^a.	2.95 ± 0.32	09.47	16.85	5.13 ± 0.36	1.23 ± 0.31	104.03 ± 35.48	56 ± 0.58
	6	500	39.04 ± 4.99^b.	2.92 ± 0.56	07.50	39.59	6.35 ± 0.63^a.	1.31 ± 0.09	101.07 ± 17.35^b.	70 ± 0.10^a.
Methanol extract	6	125	55.39 ± 8.66	3.30 ± 0.55	09.62	14.30	5.71 ± 0.67	1.19 ± 0.24	115.45 ± 12.58^b.	50 ± 0.34
	6	250	47.68 ± 2.93^b.	3.50 ± 0.44	09.39	26.23	3.73 ± 0.83	1.65 ± 0.55	100.50 ± 36.70	68 ± 0.35^a.
	6	500	19.40 ± 3.74^b.	3.11 ± 0.99	06.40	69.98	4.03 ± 2.30	3.43 ± 1.99	95.48 ± 8.36 ^b.	82 ± 0.78^b.

n, number of rats per group; I, inhibition; US, ulcer surface.

^a.p ≤ 0.05

^b.p ≤ 0.01, statistically significant relative to control.