Real-World Clinical Data Identifies Gender-related Profiles in Chronic Obstructive Pulmonary Disease

Figures & data

Figure 1 Recruitment process of the COPD patients in the two main university hospital districts of southern Finland years 2005–2007.

Table 1 Basic clinical characteristics compared between men and women participating the study

Characteristic feature	Men N = 473	Women N = 266	Significance p-value
Age, mean (yrs)	59 (± SD 7.3)	58 (± SD 7.0)	ns.
Duration of the disease, mean (yrs)	5.6 (± SD 4.4)	5.6 (± SD 3.6)	ns.
Pack-years, mean	55 (± SD 20)	45 (± SD 18)	< 0.0001^1
Baseline (% predicted, mean)
• FEV1	56.6 (±SD 18.7)	61.4 (±SD 18.8)	0.001^1
• FVC	72.0 (±SD 18.4)	76.2 (±SD 17.2)	0.004^1
• FEV1/FVC	0.63 (±SD 0.14)	0.65 (±SD 0.15)	ns.
• PEF	63.6 (± SD 20.7)	67.8 (±SD 22.1)	0.03^1
After bronchodilatation (% of predicted)
• FEV1	59.9 (± SD 17.8)	65,7 (±SD 17.4)	< 0.0001^1
• FVC	75.8 (±SD 17.2)	80.4 (±SD 16.4)	0.005^1
• FEV1/FVC ratio	0.64 (±SD 0.13)	0.66 (±SD 0.14)	0.005^1
• PEF	67.5 (±SD 20.2)	72.2 (±SD 21.5)	0.002^1
Proportion (%) of patients with
• FEV1>80 %	14.3	20.9
• 50%≤FEV1 < 80%	55.3	58.2
• 30%≤FEV1 < 50%	23.3	17.3	0.002^2
• FEV1<30%	7.0	3.6
GOLD criteria
• Stage 0: FEV1>80%	10.2	18.5	0.001^2
• Stage 1: FEV1/FVC < 70%, FEV1 ≥ 80%	4.1	2.4
• Stage 2: FEV1/FVC < 70%, 50%≤FEV1 < 80%	34.2	32.5
• Stage 3: FEV1/FVC < 70%, 30%≤FEV1 < 50%	21.4	16.5
• Stage 4: FEV1/FVC < 70%, FEV1 < 30%	6.3	3.6
• undetermined: FEV1/FVC ≥ 70%, FEV1 < 80%	23.1	26.5
DLCOcVA (% of predicted)	78.0 (±SD 21.7)	72.4 (±SD 22.1)	0.03^1
General health related QoL score (range 0-1)	0.79 (±SD 0.11)	0.79 (±SD 0.11)	ns.
Airway specific QoL score (range 20-0)	7.9 (±SD 5.0)	8.8 (±SD 5.1)	0.03^1
BMI index, mean	27.1 (±SD 4.7)	25.6 (±SD 6.1)	< 0.0001^1
Proportion of patients with concomitant
• Coronary disease	26.6	12.4	< 0.000^2
• Cerebrovascular disease	8.9	5.3	0.05^2
• Diabetes	17.5	10.5	0.006^2
• Claudication	5.7	2.3	0.02^2
• Alcoholism	18.2	9.0	< 0.000^2
• Psychiatric disorders	8.7	13.2	0.06^2
• Hypertension	41.2	39.5	ks

¹Mann-Whitney U-test ²Chi-square test.

Figure 2 At diagnosis the proportion of men (grey bars) had more severe obstruction than women (white bars).

Figure 3 The correlation between FEV₁ (% of predicted) and DLCOcVA (% of predicted) was significantly stronger in women than in men.

Figure 4 The distribution between COPD phenotype components irreversible, asthma like reversible airway obstruction, and impaired diffusion (DLCOcVA < 65% of predicted) in the cohort.