Evaluation of Seven Different Brands of Metformin Hydrochloride Tablets Available in the Market in Gondar City, Ethiopia

Figures & data

Figure 1 Chemical structure of metformin hydrochloride.

Table 1 Profile of Sampled Metformin Hydrochloride Tablets Marketed in Gondar, Ethiopia

Code	Trade name/ Type of Tablet	Batch Number	Manu. Date	Expiry Date	Country of Origin	Manufacturer
M1	Glucophage/film-coated	F0582	10/18	09/23	France	Merck santé s.a.s
M2	Metformin Denk/film-coated	9NP	10/18	09/23	Germany	Denk Pharma GmbH &Co. KG
M3	Metformin/film coated	JG9688	08/18	08/21	Poland	Lek S. A
M4	Brot/film-coated	A1K108	10/17	10/22	Cyprus	Medochemie Ltd
M5	Insumet/film-coated	D19001T212	02/19	01/22	Ethiopia	Cadila Pharmaceuticals PLC
M6	Gluformin/film- coated	26,232	06/19	06/21	Ethiopia	Addis Pharmaceutical Factory S.C
M7	Bigomet/uncoated	M101L038E	11/18	10/21	India	Aristo Pharmaceuticals Pvt. Ltd.

Table 2 Uniformity of Weight of the Different Brands of Metformin Hydrochloride Tablets Marketed in Gondar, Ethiopia

Brand	Total weight (g)	Mean Weight (g)±SD*	NO. of Tablets Deviating by ±5%	NO. of Tablets Deviating by ±10%
M1	10.63	0.530±0.005	Nil	Nil
M2	13.036	0.652±0.0037	Nil	Nil
M3	10.486	0.523±0.0048	Nil	Nil
M4	13.497	0.674±0.006	Nil	Nil
M5	13.160	0.655±0.0103	Nil	Nil
M6	13.275	0.663±0.0068	Nil	Nil
M7	13.605	0.680±0.00684	Nil	Nil

Abbreviation: SD, standard deviation.

Table 3 Friability of the Different Brands of Metformin Hydrochloride Tablets Marketed in Gondar City, Ethiopia

Brand	Initial Weight (Wi/g)	Final Weight (Wf/g)	Weight Loss	% Weight Loss
M1	7.96	7.96	0	0.00
M2	9.79	9.76	0.03	0.306
M3	7.81	7.78	0.03	0.385
M4	10.14	10.13	0.01	0.0986
M5	9.85	9.83	0.02	0.203
M6	9.93	9.92	0.01	0.1007
M7	10.22	10.21	0.01	0.098

Table 4 Hardness of the Different Brands of Metformin Hydrochloride Tablets Available in the Gondar City, Ethiopia

BRAND	Mean Force Applied (Kg±SD)
M1	15.325±0.82
M2	16.979±1.013
M3	23.022±2.67
M4	23.588±1.91
M5	21.696±2.16
M6	20.691±1.433
M7	19.815±1.764

Table 5 Disintegration Time of the Different Brands of Metformin Hydrochloride Tablets Available in the Gondar City, Ethiopia

Brand	Disintegration Time/Min
M1	7.33
M2	9.20
M3	7.20
M4	7.40
M5	12.07
M6	8.11
M7	9.25

Table 6 Assay of the Different Brands of Metformin Hydrochloride Tablets Available in the Gondar City, Ethiopia

BRAND	Mean Absorbance	Assay (%)
M1	0.8426	102.763
M2	0.7756	97.135
M3	0.7865	97.174
M4	0.8081	99.784
M5	0.8061	98.173
M6	0.8787	101.862
M7	0.7203	96.553

Table 7 Percentage Released (Dissolution) of Metformin Hydrochloride Tablets Available in Gondar City, Ethiopia

Brand	Drug Released (%)
	30 min	45 min
M1	84.4	88.3
M2	81.7	86.4
M3	87.1	92.6
M4	77.5	86.8
M5	69.3	78.9
M6	78.8	84.4
M7	76.2	87.6

Data Sharing Statement

All relevant data can be obtained from the corresponding author upon reasonable request.