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ORIGINAL RESEARCH

Evaluation of Wound Healing Activity of Hydromethanolic Crude Extract and Solvent Fractions of the Root of Verbascum Sinaiticum Benth. (Scrophulariaceae) in Swiss Albino Mice

ORCID Icon, ORCID Icon & ORCID Icon
Pages 143-158 | Received 12 Jan 2024, Accepted 20 Mar 2024, Published online: 26 Mar 2024

Figures & data

Figure 1 The photograph of Verbascum sinaiticum January 2021, Maraki campus, University of Gondar, Gondar, Amhara regional state, Ethiopia.

Figure 1 The photograph of Verbascum sinaiticum January 2021, Maraki campus, University of Gondar, Gondar, Amhara regional state, Ethiopia.

Table 1 Formula Used for the Preparation of Simple and Medication Ointment

Figure 2 Photograph of incision wound. (a) On the day of wound creation; (b) water flow technique; (c) measuring breaking strength.

Figure 2 Photograph of incision wound. (a) On the day of wound creation; (b) water flow technique; (c) measuring breaking strength.

Table 2 Preliminary Phytochemical Screening of the Crude Extract and Solvent Fractions of the Root of V. Sinaiticum

Table 3 The Effect of the Root Verbascum Sinaiticum Crude Extract on Excision Wound Area (mm2) in Swiss Albino Mice

Figure 3 Photograph of excision wound mice treated with simple ointment, 5% crude extract,10% crude extract and nitrofurazone 0.2%.

Abbreviations: SO, Simple Ointment; VS, Verbascum Sinaiticum; NF, Nitrofurazone.
Figure 3 Photograph of excision wound mice treated with simple ointment, 5% crude extract,10% crude extract and nitrofurazone 0.2%.

Figure 4 Photograph of the histological specimen of excision wound tissue. (a) Histological section of simple ointment; (b) Histological section of 5% crude extract; (c) Histological section of 10% crude extract; (d) Histological section of Nitrofurazone.

Figure 4 Photograph of the histological specimen of excision wound tissue. (a) Histological section of simple ointment; (b) Histological section of 5% crude extract; (c) Histological section of 10% crude extract; (d) Histological section of Nitrofurazone.

Table 4 Effect of Crude Extract of the Root of Verbascum Sinaiticum Extract on Tensile Strength in an Incision Wound Model

Table 5 Effect of the Crude Extract of the Root of Verbascum Sinaiticum Extract on Burn Wound Model in Swiss Albino Mice

Figure 5 Photograph of burn wound in mice treated with simple ointment, 5% VS crude extract, 10% VS crude extract, and nitrofurazone 0.2%.

Abbreviations: SO, Simple Ointment; VS, Verbascum Sinaiticum; NF, Nitrofurazone.
Figure 5 Photograph of burn wound in mice treated with simple ointment, 5% VS crude extract, 10% VS crude extract, and nitrofurazone 0.2%.

Table 6 Effect of Solvent Fractions of Verbascum Sinaiticum Root on Excision Wound Area in Swiss Albino Mice

Figure 6 Effect of solvent fractions of Verbascum sinaiticum on epithelialization period. a, compared to simple ointment; *=P<0.001.

Abbreviations: SO, Simple ointment; CF, Chloroform; EA, Ethyl acetate; AQ, Aqueous; NF, Nitrofurazone 0.2%.
Figure 6 Effect of solvent fractions of Verbascum sinaiticum on epithelialization period. a, compared to simple ointment; *=P<0.001.