Recalling P446. P4501A1 (CYP1A1) Opting for Clinical Application

Abstract

This review goes back to spectral studies [see ]. The findings of apparent absolute spectra of two interconvertible forms of microsomal mixed function oxidases are looked back on to recall whether their impact sustained scrutiny or are rather remembered as of sentimental value only.

The second part summarizes studies on the clinical relevance of CYP1A1 with special reference to our investigations. The impact of genetic variability of CYP1A1 on cancer susceptibility, differential effects of polyphenols and hyperforin on toxification and detoxification pathways of benzo[a]pyrene, and differential metabolite patterns of 17ß-estradiol, estrone, and eicosapentaenoic acid are presented.

Key Words :

• Cytochrome P450
• P446
• P448
• CYP1A1
• Spin state
• Extinction coefficients
• Absolute spectra
• Methylcholanthrene
• Phenobarbital
• Benzo[a]pyrene
• Epoxidation
• Diolepoxide-2
• Genetic polymorphism
• 17ß-estradiol
• Hyperforin
• St. John's wort

Notes

¹CC/NUMBER 38, September 20, 1993 Citation Classic.

²http://drnelson.utmem.edu/CytochromeP450.html.