ABSTRACT
The aim was to examine the diagnostic efficacy of hippocampal subregions volume and texture in differentiating amnestic mild cognitive impairment (MCI) from normal aging changes. Ninety MCI subjects and eighty-eight well-matched healthy controls (HCs) were selected. Twelve hippocampal subregions volume and texture features were extracted using Freesurfer and MaZda based on T1 weighted MRI. Then, two-sample t-test and Least Absolute Shrinkage and Selection Operator (LASSO) regression were developed to select a subset of the original features. Support vector machine (SVM) was used to perform the classification task and the area under the curve (AUC), sensitivity, specificity and accuracy were calculated to evaluate the diagnostic efficacy of the model. The volume features with high discriminative power were mainly located in the bilateral CA1 and CA4, while texture feature were gray-level non-uniformity, run length non-uniformity and fraction. Our model based on hippocampal subregions volume and texture features achieved better classification performance with an AUC of 0.90. The volume and texture of hippocampal subregions can be utilized for the diagnosis of MCI. Moreover, we found that the features that contributed most to the model were mainly textural features, followed by volume. These results may guide future studies using structural scans to classify patients with MCI.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Author Contributions
All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Tongpeng Chu, Bin Gui, Zhongsheng Zhang, Gang Zhang and Fanghui Dong. Critical revision of the manuscript for important intellectual content were performed by Jianli Dong, Shujuan Lin. The first draft of the manuscript was written by Tongpeng Chu and Yajun Liu, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
Consent to Participate
Informed consent was obtained from all individual participants included in the study.
Consent to Publish
The authors affirm that human research participants provided informed consent for publication of the images in Figure A1.
Data availability statement
The datasets used and/or analyzed during the current study available from the corresponding author on reasonable request.