ABSTRACT
Purpose
We explore the choroid vasculature changes of acute Vogt–Koyanagi–Harada (VKH) disease using widefield optical coherence tomography angiography (OCTA).
Methods
In this retrospective, observational, longitudinal study, 16 patients with acute VKH disease (32 eyes, mean age: 42.19 ±13.66 years) were measured using widefield OCTA.
Results
In this study, we first described the multiple dark foci in choriocapillaris and Sattler’s layer in the panoramic montage of the five 12x12mm images in 30 eyes (93.8%) of acute VKH disease. OCTA follow-up in these 30 eyes demonstrated the diminished size and number of these dark foci in choriocapillaris and Sattler’s layer after the initiation of treatment.
Conclusions
Widefield OCTA enables noninvasive identification of characteristics of flow void at the level of superficial choroidal vessels in the acute phase and may be a novel valuable tool for diagnosis and monitoring of disease progression in VKH disease in the future.
Acknowledgments
The author would like to thank all the participants and the staffs for their valuable contribution to this research.
Authors’ contributions
XYD wrote the main manuscript text. QMS prepared all figures and tables. XYD, XYB, and QMS performed OCTA scans and helped with data collections. QC, GZX, and LC assisted in the manuscript writing and helped reviewed the manuscript. LC performed ophthalmic examinations and clinical assessments of patients.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Ethical approval
This study was approved by the Institutional Review Board (No. 2020119) of Eye and ENT Hospital of Fudan University and conformed to the tenets of the Declaration of Helsinki. Informed consent has been obtained from each patient.
Supplementary material
Supplemental data for this article can be accessed online at https://doi.org/10.1080/09273948.2023.2181186
Correction Statement
This article has been corrected with minor changes. These changes do not impact the academic content of the article.