Omega-3 fatty acids differentially influences embryotoxicity in subtypes of preeclampsia

ABSTRACT

Background: Early (EOP) and late onset (LOP) preeclampsia are two subtypes of preeclampsia. This study examines the effect of maternal omega-3 fatty acids and vitamin E supplementation in a rat model of preeclampsia.

Method: Pregnant Wistar rats were assigned to control; EOP; LOP; EOP+omega-3 fatty acid supplementation+vitamin E and LOP+omega-3 fatty acid supplementation+vitamin E. L-Nitroarginine methylester was used to induce preeclampsia. Blood Pressure (BP) was recorded during pregnancy and dams were dissected at d14 and d20 of gestation.

Results: Animals from EOP and LOP groups demonstrated higher systolic and diastolic BP, lower weight gain, lower conceptuses size, lower conceptuses weight and fetal weight as compared to control. EOP and LOP groups showed higher percentage of fetal resorptions and embryotoxicity (deformities and hematomas).

Conclusion: Supplementation reduced the diastolic BP, percentage of resorptions and embryotoxicity only in the LOP group, suggesting a need for differential supplementation regime for the two subtypes of preeclampsia.

KEYWORDS:

• Embryo
• conceptuses size
• fatty acid
• preeclampsia
• vitamin E

Acknowledgments

We would like to thank the animal house staff for their assistance in the animal house.

Declaration of interest

The author(s) declare no potential conflict of interest with respect to the research, authorship, and/or publication of this article.

Additional information

Funding

This work was supported by Indian Council of Medical Research (ICMR), New Delhi, India grant number. [5/7/1069/13-RCH]. Author VK is the recipient of an ‘INSPIRE fellowship’ from the Department of Science and Technology, Government of India.