A new phenalenone derivative from the soil fungus Penicillium herquei PSU-RSPG93

Abstract

One new phenalenone derivative, peniciherqueinone (1), together with five known phenalenone derivatives (2–6), one known anthraquinone (7) and two known acetophenones (8 and 9) were isolated from the soil fungus Penicillium herquei PSU-RSPG93. Their structures were established by spectroscopic evidence. The absolute configuration of 1 was determined by anisotropic effect and electronic circular dichroism spectroscopy. Compound 2 exhibited mild antioxidant activity and is noncytotoxic to Vero (African green monkey kidney fibroblasts) cell lines.

Keywords::

• Penicillium herquei
• soil fungus
• phenalenone
• anthraquinone

Acknowledgements

We thank the Center of Excellence for Innovation in Chemistry (PERCH-CIC) and Prince of Songkla University for partial support, and also the National Center for Genetic Engineering and Biotechnology (BIOTEC) for the cytotoxic activity testing.

Additional information

Funding

C. Tansakul thanks the Thailand Research Fund for the TRF Senior Research Scholar (grant number RTA5480002) to Prof. V. Rukachaisirikul.