Thiazole derivatives: prospectives and biological applications

Abstract

Thiazole derivatives have long been a hot topic in pharmaceutical research and remain among the greatest active fields in heterocyclic chemistry. Thiazole derivatives, as one of the potentially favored structure, have been extensively desirable by industrial and medicinal researchers and have gained significant success in the previous decades due to their various biological activities, such as anticancer, antibacterial, antifungal, anti-HIV, antiulcer, and anti-inflammatory activity. In addition, many thiazole drugs are well-known pharmaceuticals on the market.

This review summarizes the freshly synthesized routes and prospective biological activities of thiazole derivatives. In addition, it highlights thiazoles as treatment drugs in clinical trials or approved by the FDA and spotlights on some of their industrial applications. On the other hand, one of the goals of this review is to open up prospects for the future design, development, and usage of thiazole derivatives as potent drugs.

GRAPHICAL ABSTRACT

KEYWORDS:

• Thiazole derivatives
• synthesis
• thiazole drugs
• industrial applications
• biological activity

Disclosure statement

No potential conflict of interest was reported by the author(s).

ARTHUR RUDOLF HANTZSCH

Great Chemist, Teacher, and Pioneer of Thiazole Chemistry