Development and Dissolution Velocity Studies of an Oral Albendazole Nanocrystal Solid Formulation

ABSTRACT

During the last 10 years, the formulation of drugs as nanocrystals has rapidly evolved into a mature drug delivery strategy, with currently five products on the market. The major characteristic of these systems is the rapid dissolution velocity, enabling bioavailability enhancement after oral administration. This study describes the preparation of a solid dosage tablet form of spray-dried albendazole nanocrystal and compares its dissolution behavior with a market tablet in different media. The aim was to obtain a stable nanocrystal loaded drug tablet with an increased drug saturation solubility and dissolution velocity. Solubility and dissolution experiments were performed to verify the obvious improvement of the dissolution behavior compared with the commercial product. Improved dissolution behavior in drug nanocrystal-loaded solid dosage forms should lead to better bioavailability of poorly soluble drugs in the body.

KEYWORDS:

• albendazole
• nanocrystal
• tablet
• dissolution evaluation

Acknowledgments

Facilities were obtained from Torrent Research Center, Ahmedabad, High Security Animal Disease Laboratory, Bhopal and Central Food Technological Research Institute, Mysore.