Encapsulated iodine–chitosan graphene oxide nanocomposite: fabrication and evaluation for antibacterial activity

ABSTRACT

Chronic wounds pose a significant challenge to wound care professionals and have substantial cause of socioeconomic implications worldwide. This study focuses on the development of a gel containing encapsulated iodine–chitosan graphene oxide nanopockets (I-CH-GO-NPOs) with a comprehensive evaluation to discern its potential in enhancing the wound healing trajectory for full thickness chronic wounds. The prepared I-CH-GO-NPOs gel showed higher antibacterial property of 0.00513 ± 0.00014 mg/ml against gram-positive Staphylococcus aureus bacteria. Further, in vivo wound healing efficacy of I-CH-GO-NPOs was evaluated in Sprague-Dawley rats which showed a significant increase of 99.89 ± 2.2% in the wound contraction.

KEYWORDS:

• Chitosan
• graphene oxide
• iodine
• nanoparticles
• wound healing

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Notes on contributors

Priyanka Chhabra

Priyanka Chhabra, an Assistant professor, with expertise in the field of Biomaterial, Drug development for Biomedical applications at Centre for Medical Biotechnology Amity University, Noida Uttar Pradesh, India.

Gaurav Chauhan

Gaurav Chauhan, a Research Professor in BioEngineering, with expertise in Nanomedicine, Regenerative Biomaterials, Bio MEMS, and Nano-Bio Interface, also serves as a core researcher in the NANO Sensors and Devices research group at Tec de Monterrey.

Anjali Gupta

Anjali Gupta, Professor with expertise in bio-organic and synthetic chemistry and drug development for biomedical applications at School of Basic Sciences, Galgotias University, Greater Noida.

Divya Tripathy

Divya Tripathy, Professor with expertise in synthetic chemistry and drug development for biomedical applications at School of Basic Sciences, Galgotias University, Greater Noida.

Amit Tyagi

Amit Tyagi, Scientist “F” with expertise in Drug Formulation and Development at Institute of Nuclear Medicine and Allied Science, DRDO, Delhi, India Robin Chauhan, an undergraduate scholar pursuing his Bachelors in Pharmaceutical Sciences, focuses his research on Nanopharmaceuticals and Biodiagnostics.