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Research Article

A fractional order co-infection model between malaria and filariasis epidemic

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Pages 132-153 | Received 13 Oct 2023, Accepted 01 Feb 2024, Published online: 15 Feb 2024

Abstract

In this article, we investigate a mathematical malaria-filariasis co-infection model with the assistance of the non-integer order operator. Using the fractal-fractional operator in the Caputo-Fabrizio (CF) sense, it has been possible to understand the dynamical behaviour and complicatedness of the malaria-filariasis model. An investigation of the existence and uniqueness of the solution employs fixed-point theory. Ulam-Hyers stability helps examine the stability analysis of the proposed co-infection model. The malaria-filariasis model has been investigated using the Toufik-Atanagana (TA), a sophisticated numerical method for these biological co-infection models. With the help of numerical procedures, we provide the approximate solutions for the proposed model. A variety of fractal dimension and fractional order options are utilized for the presentation of the results. When we adjust sensitive parameters like τ and γ, the graphical representation illustrates the system’s behaviour and identifies suitable parameter ranges for solutions. In addition, we evaluate the model along with the regarded operators and various β1 values using an exceptional graphical representation.

1. Introduction

Fractional calculus is an effective tool used to solve mathematical problems in the real world. Fractional-order derivatives find numerous applications in various fields such as numerical analysis, physics, and biomathematics. This field is gaining popularity among researchers due to its potential to provide plausible results. Fractional-order derivatives are essential in evaluating biological models (Miller & Ross, Citation1993; Sabatier, Agrawal, & Machado, Citation2007). Some fractional derivatives have singular kernels, while others have non-singular kernels. The fractal-fractional operator is a more accurate and efficient operator commonly used in biological models. The Caputo, Caputo-Fabrizio (CF), and Atangana-Baleanu (AB) types of fractal fractional derivatives are powerful tools for analyzing biological systems and other models. Memory effects are often observed in biological systems, making the usefulness of fractional-order operators even more essential in these cases.

Today, Malaria – filariasis coinfection is becoming a hazardous disease for the world. This disease is an old parasitic disease for human beings. This disease is arising as a critical situation created for the world population. This illness is a medical challenge at this time for researchers and doctors. We see a high effect of this disease in Africa and Asia; These continents, in this illness, have an enormous death rate. The World Health Organization says that in 2018 approximately 438,000 people died from the sickness of malaria; 90 per cent of deaths occurred only in Africa (World Health Organization, n.d.). Malaria is a disease spread by a mosquito’s bite; when infected mosquitoes bite a human, the virus of this disease enters the human body (Nzeako, Okunnuga, Nduka, & Ezenwaka, Citation2016). The female anopheles mosquito plays a central role in the dispersion of malaria (Amoah-Mensah, Dontwi, & Bonyah, Citation2018; Mutua, Wang, & Vaidya, Citation2015; Okosun & Makinde, Citation2014). When we are infected with malaria, the symptoms of this illness like high fever, pain in the head, feeling the cold, and muscle aches. In some cases, patients have also suffered from vomiting and diarrhoea. Some of the patients infected with malaria have also been infected with anaemia and jaundice because of this disease’s effect on the red blood cells of the human body. Every year, approximately 290 million people suffer from malaria. The death rate is more than we think, and about 400,000 people die from this disease each year.

Filariasis is a disease that can spread through mosquito bites. It is caused by three types of filaria parasites, which are known as Wuchereria bancrofti, Brugia timori, and Brugia malayi. According to a 2018 report by the World Health Organization, around 856 million people in 52 countries are at risk of contracting filariasis. To prevent the spread of this parasitic disease, it is important to take precautions and use preventive chemotherapy (Abdullahi, Alaku, & Hudu, Citation2015; Adegnika et al., Citation2010; Chandrakala & Zulfeen, Citation2016). When a mosquito bites a person who has lymphatic filariasis, the mosquito can also become infected. This is because the person’s blood contains microscopic worms that enter the mosquito’s body. When the infected mosquito bites another person, the microscopic worms can enter their skin and blood, causing the infection to spread. The worms can live in the lymphatic vessels for up to 8 years and produce many microfilariae (Bhunu & Mushayabasa, Citation2012). Symptoms of lymphatic filariasis include swelling in the legs, arms, breasts, and genitals.

Fractional calculus has become a widely studied branch of mathematics in recent years, and its applications have greatly enhanced the field of mathematical analysis (Mainardi, Citation2012). In particular, fractional calculus has proven to be a valuable tool for modelling biological processes that involve memory effects. For example, when developing a mathematical model of an infectious disease in the natural sciences, the use of fractional-order derivatives is crucial for finding numerical solutions (Kumar, Kumar, Samet, & Dutta, Citation2021; Kumar, Kumar, Samet, Gómez-Aguilar, & Osman, Citation2020; Kumar & Kumar, Citation2022). These derivatives are more efficient and effective than integer-order derivatives when dealing with biological systems (Caputo, Citation1969). A significant concept in the study of derivatives in fractional calculus is the Caputo derivative, which has a singular kernel, but there are also other operators like the CF operator and AB operator that have nonsingular kernels (Caputo & Fabrizio, Citation2015; Kiryakova, Citation1993). In the past few years, several biological models have been solved with the help of fractional derivatives (Losada & Nieto, Citation2015; Uçar, Uçar, Özdemir, & Hammouch, Citation2019). However, dealing with fractional-order biological systems can be challenging due to non-linearity. The SVIR epidemic model is thoroughly examined by the authors, who utilize Lyapunov functions to provide methods for preventing the spread of disease (Alkhazzan, Wang, Nie, Khan, & Alzabut, Citation2023). This paper (Kumar, Kumar, & Jleli, Citation2022),, provides insights on how to investigate the dynamics and complexity of food chain models. Some of the notable derivatives include the AB derivative, which has become a pillar of fractional calculus in recent decades (Alkahtani & Atangana, Citation2016). The authors utilize a fractional differential operator to conduct a thorough examination of the tumour growth model that incorporates nonlinearity (Alzabut, Dhineshbabu, Selvam, Gómez-Aguilar, & Khan, Citation2023). Fractal-fractional operators have three different types of kernel, including power law, exponential decay, and Mittag-Leffler. These operators are considered reliable for biological models and are significant from a researcher’s perspective. It has been noted that the analytical and numerical computations for various fractional-order and fractal dimensions support the dynamics converging effects more strongly than they do for an integer order. The authors analyze the impact of waterborne diseases and COVID-19 using the fractal-fractional operator on human health (Khan, Alzabut, Shah, et al., Citation2023; Khan, Alzabut, Tunç, et al., Citation2023). In this paper, we analyze a nonlinear model and propose a practical and efficient solution plan.

1.1. A Summary of the paper

The following parts provide an organized breakdown of the entire work: Section 2 provides fundamental definitions for fractional calculus. The fractal-fractional model of malaria and filariasis is discussed in section 3 of this article. In section 4, we discuss the uniqueness, and existence of the model solution, non-negativity, and as well as its stability. Section 4 is further broken into sections 4, 4.1 and 4.2. In Section 5, numerical techniques for a model of fractional order malaria and filariasis are described. In Section 6, there is a numerical simulation and comments. Section 7 provides the conclusion.

2. Preliminaries

In this section, we look at a few fractional operator definitions and theorems in detail.

Definition 2.1

(Atangana & Qureshi, Citation2019; Li, Liu, & Khan, Citation2020). Let F(t) should be a continuous function in an open interval (a, b) and along with fractional order 0<β11 and fractal dimension 0<β21, in the Riemann-Liouville (RL) derivative with power law kernel is defined as follows: (1) FFP0D0,tβ1,β2(F(t))=1Γ(kβ1)ddtβ20t(tu)kβ11F(u)du,(1) with k1<β1,β2kN and dF(u)duβ2=limtuF(t)F(u)tβ2uβ2.

Definition 2.2

(Atangana & Qureshi, Citation2019; Li et al., Citation2020). Let F(t) should be a continuous function in an open interval (a, b) and along with fractional order 0<β11 and fractal dimension 0<β21, in the Riemann-Liouville (RL) derivative with exponentially decaying kernel is defined as follows: (2) FFE0D0,tβ1,β2(F(t))=B(β1)1β1ddtβ20texp(β11β1(tu))F(u)du,(2) the normalized constant is defined as follows: B(0)=1, B(1)=1.

Definition 2.3

(Atangana & Qureshi, Citation2019; Li et al., Citation2020). Let F(t) should be a continuous function in an open interval (a, b) and along with fractional order 0<β11 and fractal dimension 0<β21, with power law kernel is defined as follows: (3) FFP0I0,tβ1,β2(F(t))=β2Γ(β1)0t(tu)β11uβ21F(u)du.(3)

Definition 2.4

(Atangana & Qureshi, Citation2019; Li et al., Citation2020). Let F(t) should be a continuous function in an open interval (a, b) and along with fractional order 0<β11 and fractal dimension 0<β21, with exponential decay kernel is defined as follows: (4) FFE0I0,tβ1,β2(F(t))=β2(1β1)tβ21F(t)B(β1)+β1β2B(β1)0tuβ21F(u)du.(4)

Theorem 2.1

(Ali, Shah, Zada, & Kumam, Citation2020; Granas & Dugundji, Citation2003). Let Θ:ΦΦ be an operator and completely continuous. Let S(Θ)={ShΦ:Sh=ςΘ(Sh),ς[0,1]}.

The operator Θ has at least one fixed point or the set S(Φ) is not bounded.

Lemma 2.1

(Xu, Saifullah, Ali, & Adnan, Citation2022). This problem has a solution FFE0D0,tβ1,β2H(t)=F(H(t),t)+φ(t)H(0)=H0, if the following condition is true, (5) |H(t){H(0)+(F(H(t),t)φ0(t))β2(1β1)B(β1)tβ21+β1β2B(β1)0tuβ11F(H(u),u)du}|(β2(1β1)Tβ21B(β1)+β2Tβ1B(β1))F.(5)

3. The mathematical formulation of the malaria-filariasis model

In this part, we convey fractional malaria-filariasis behavior and depict the proposed model. We have nine equations in our malaria-filariasis system. In this model, the complete population of pregnant women at the time “t” is divided into separate subpopulations. Sh represents the individual pregnant women who adhered to a medical prenatal program. Individually susceptible women who do not follow the antenatal medical regimen are classified as S2. Im represents those pregnant women only infected with malaria; If represents those pregnant women only infected with filariasis. Imf represents those pregnant women infected with both malaria and filariasis. T represents those pregnant women treated for malaria-filariasis. That’s why Nh=T+Imf+If+Im+S2+Sh. Because the same vector that spreads malaria also spreads filariasis (Anopheles mosquito), this vector population is represented by Nυ. The Sυ stands for the susceptible mosquito; the Eυ for the exposed mosquito, and the Iυ for the infected mosquito, therefore Nυ=Iυ+Eυ+Sυ. The host population is recruited from the population of susceptible pregnant women who adhere to the medical prenatal program at a steady per capita rate of Ah. The fraction of pregnant women who are complying with antenatal medical programs is represented by the π, and τ is represented by the rate of loss of immunity to both malaria and filariasis. The natural death rate was represented by μh, while the rate of progression from Sh to S2 was represented by δ. KmaSh and KfSh have been chosen to depict the force of infection. That’s why Kma=αaIνNh, and Kf=β(Im+Imf+kIf)Nh. μh is the rate at which pregnant women die naturally, and the disease-induced death rate is denoted by the letter γ. σh is the percentage of susceptible pregnant women who do not comply with the antenatal medical program that develops malaria symptoms. ϕ1 stands for the rate at which malaria is treated, and ψ stands for the pace at which malaria progresses to the point when filariasis symptoms appear. The treatment rate for filariasis is denoted by ϕ2, whereas the treatment rate for malaria-filariasis is denoted by ϕ3. The recruitment of mosquitoes has determined the rate Aν of change in the susceptible mosquito population. The force of infection that created a rate of change in the exposed mosquito population has been denoted as the Kν. μυ represents the natural mortality rate of mosquitoes, and συ denotes a decrease in the pace of mosquito progression. α represents the rate of mosquito bites. The chance of malaria transmission in pregnant women per bite was represented by a, whereas the transmission rate between infectious and susceptible mosquitoes was represented by Kυ. b is the likelihood that any pregnant woman with the infection will cause mosquitoes to transmit the disease. β represents the actual contact rate of infection between infectious groups. Other modification parameters, such as ϵ, θ, ρ, and ν, are also present, as we know.

The following assumptions are included in the model’s construction:

  • In the tropics, we solely consider the population of pregnant women who are considered lonely.

  • Birth and death rates exist.

  • The mother and the kids have no vertical transmission.

  • Malaria and filariasis disease-contaminated pregnant ladies have treatment also available.

  • When pregnant women are infected with this disease, then after the treatment affects immunity; therefore, the possibility of again being infected with this disease.

This paper presents a realistic and well-posed domain for an epidemic model. However, due to state variables and parameter variations, medical intervention strategies such as treatment are required to control the spread of co-infectious diseases. Therefore the proposed co-infection model (Ogunmiloro, Citation2019) is written as: (6) dShdt=πAhμhShδShKfShKmaSh+τT,dS2dt=(1π)Ah+KfSh+KmaSh+δShϵσhS2γS2μhS2,dImdt=ϵσhS2ψImϕ1ImμhImθKfIm,dIfdt=ψImγIfϕ2IfμhIfρKmaIf,dImfdt=θKfIm+ρKmaIfϕ3ImfυϕImfηγImfμhImf,dTdt=ϕ1Im+ϕ2If+υϕImf+ϕ3ImfμhTτT,dSυdt=AυKυSυμυSυ,dEυdt=KυSυσυEυμυEυ,dIυdt=συEυμυIυ,(6) with the initial conditions Sh(0)=Sh,0,S2(0)=S2,0,Im(0)=Im,0,If(0)=If,0,Imf(0)=Imf,0,T(0)=T0,Sυ(0)=Sυ,0,Eυ(0)=Eυ,0,Iυ(0)=Iυ,0.

We operate the fractal fractional-order derivative in system Equation(6), then we get (7) FFE0D0,tβ1,β2Sh=πAhμhShδShKfShKmaSh+τT,FFE0D0,tβ1,β2S2=(1π)Ah+KfSh+KmaSh+δShϵσhS2γS2μhS2,FFE0D0,tβ1,β2Im=ϵσhS2ψImϕ1ImμhImθKfIm,FFE0D0,tβ1,β2If=ψImγIfϕ2IfμhIfρKmaIf,FFE0D0,tβ1,β2Imf=θKfIm+ρKmaIfϕ3ImfυϕImfηγImfμhImf,FFE0D0,tβ1,β2T=ϕ1Im+ϕ2If+υϕImf+ϕ3ImfμhTτT,FFE0D0,tβ1,β2Sυ=AυKυSυμυSυ,FFE0D0,tβ1,β2Eυ=KυSυσυEυμυEυ,FFE0D0,tβ1,β2Iυ=συEυμυIυ,(7) with the initial conditions Sh(0)=Sh,0,S2(0)=S2,0,Im(0)=Im,0,If(0)=If,0,Imf(0)=Imf,0,T(0)=T0,Sυ(0)=Sυ,0,Eυ(0)=Eυ,0,Iυ(0)=Iυ,0.

4. Existence and uniqueness of the solution

In this part, we build the existence theory for the proposed model. Now, we rewrite the system Equation(7) with this structure as follows: (8) CF0D0,tβ1Sh(t)=β2tβ21(F1(Sh(t),t)),CF0D0,tβ1S2(t)=β2tβ21(F2(S2(t),t)),CF0D0,tβ1Im(t)=β2tβ21(F3(Im(t),t)),CF0D0,tβ1If(t)=β2tβ21(F4(If(t),t)),CF0D0,tβ1Imf(t)=β2tβ21(F5(Imf(t),t)),CF0D0,tβ1T(t)=β2tβ21(F6(T(t),t)),CF0D0,tβ1Sυ(t)=β2tβ21(F7(Sυ(t),t)),CF0D0,tβ1Eυ(t)=β2tβ21(F8(Eυ(t),t)),CF0D0,tβ1Iυ(t)=β2tβ21(F9(Iυ(t),t)),(8) where {F1(Sh(t),t)=πAhμhShδShKfShKmaSh+τT,F2(S2(t),t)=(1π)Ah+KfSh+KmaSh+δShϵσhS2γS2μhS2,F3(Im(t),t)=ϵσhS2ψImϕ1ImμhImθKfIm,F4(If(t),t)=ψImγIfϕ2IfμhIfρKmaIf,F5(Imf(t),t)=θKfIm+ρKmaIfϕ3ImfυϕImfηγImfμhImf,F6(T(t),t)=ϕ1Im+ϕ2If+υϕImf+ϕ3ImfμhTτT,F7(Sυ(t),t)=AυKυSυμυSυ,F8(Eυ(t),t)=KυSυσυEυμυEυ,F9(Iυ(t),t)=συEυμυIυ.

System Equation(8) can be expressed as follows: (9) CF0D0,tβ1H(t)=β2tβ21F(H(t),t),H(0)=H0.(9)

We operate the fractional integral, we have H(t)=H(0)+β2tβ21(β11)B(β1)F(H(t),t)+β1β2B(β1)0tuβ21F(H(u),u)du, where H(t)={Sh(t)S2(t)Im(t)If(t)Imf(t)T(t)Sυ(t)Eυ(t)Iυ(t),F(H(t),t)={F1(Sh(t),t)F2(S2(t),t)F3(Im(t),t)F4(If(t),t)F5(Imf(t),t)F6(T(t),t)F7(Sυ(t),t)F8(Eυ(t),t)F9(Iυ(t),t)

We operate the fractal-fractional integral in the CF sense in the system Equation(8), then we get (10) Sh(t)=Sh(0)+β2(1β1)B(β1)tβ21F1(H(t),t)+β1β2B(β1)0tuβ21F1(H(u),u)du,S2(t)=S2(0)+β2(1β1)B(β1)tβ21F2(H(t),t)+β1β2B(β1)0tuβ21F2(H(u),u)du,Im(t)=Im(0)+β2(1β1)B(β1)tβ21F3(H(t),t)+β1β2B(β1)0tuβ21F3(H(u),u)du,If(t)=If(0)+β2(1β1)B(β1)tβ21F4(H(t),t)+β1β2B(β1)0tuβ21F4(H(u),u)du,Imf(t)=Imf(0)+β2(1β1)B(β1)tβ21F5(H(t),t)+β1β2B(β1)0tuβ21F5(H(u),u)du,T(t)=T(0)+β2(1β1)B(β1)tβ21F6(H(t),t)+β1β2B(β1)0tuβ21F6(H(u),u)du,Sυ(t)=Sυ(0)+β2(1β1)B(β1)tβ21F7(H(t),t)+β1β2B(β1)0tuβ21F7(H(u),u)du,Eυ(t)=Eυ(0)+β2(1β1)B(β1)tβ21F8(H(t),t)+β1β2B(β1)0tuβ21F8(H(u),u)du,Iυ(t)=Iυ(0)+β2(1β1)B(β1)tβ21F9(H(t),t)+β1β2B(β1)0tuβ21F9(H(u),u)du.(10)

In this part, we analyze the existence and uniqueness of the solution in our proposed model with the help of the fixed point theory. A Banach space can be defined as follows to demonstrate the existence and unique solution for the proposed model. We defined as Φn = G[0,T] is space of all functions Sh,S2,,Iυ respectively to n=1,2,,9. Φn generates a Banach space when provided with the norm Sh=maxt[0,T]|Sh|, S2=maxt[0,T]|S2|, , Iυ=maxt[0,T]|Iυ| respectively to n=1,2,,9. Therefore the norm is established in the product space as U=(Sh,S2,Im,If,Imf,T,Sυ,Eυ,Iυ)=(Sh,S2,,Iυ),=Sh+S2++Iυ.

A Banach space is established as Φ=(Φ1×Φ2×Φ3×Φ4×Φ5×Φ6×Φ7×Φ8×Φ9,U).

Let the operator Θ:ΦΦ is defined in system Equation(10), then we have (11) Θ(H)(t)=(Θ1(U)(t)Θ2(U)(t)Θ3(U)(t)Θ4(U)(t)Θ5(U)(t)Θ6(U)(t)Θ7(U)(t)Θ8(U)(t)Θ9(U)(t))(11) where (12) Θ1(H)(t)=Sh(0)+β2(1β1)B(β1)tβ21F1(Sh(t),t)+β1β2B(β1)0tuβ21F1(Sh(u),u)du,Θ2(H)(t)=S2(0)+β2(1β1)B(β1)tβ21F2(S2(t),t)+β1β2B(β1)0tuβ21F2(S2(u),u)du,Θ3(H)(t)=Im(0)+β2(1β1)B(β1)tβ21F3(Im(t),t)+β1β2B(β1)0tuβ21F3(Im(u),u)du,Θ4(H)(t)=If(0)+β2(1β1)B(β1)tβ21F4(If(t),t)+β1β2B(β1)0tuβ21F4(If(u),u)du,Θ5(H)(t)=Imf(0)+β2(1β1)B(β1)tβ21F5(Imf(t),t)+β1β2B(β1)0tuβ21F5(Imf(u),u)du,Θ6(H)(t)=T(0)+β2(1β1)B(β1)tβ21F6(T(t),t)+β1β2B(β1)0tuβ21F6(T(u),u)du,Θ7(H)(t)=Sυ(0)+β2(1β1)B(β1)tβ21F7(Sυ(t),t)+β1β2B(β1)0tuβ21F7(Sυ(u),u)du,Θ8(H)(t)=Eυ(0)+β2(1β1)B(β1)tβ21F8(Eυ(t),t)+β1β2B(β1)0tuβ21F8(Eυ(u),u)du,Θ9(H)(t)=Iυ(0)+β2(1β1)B(β1)tβ21F9(Iυ(t),t)+β1β2B(β1)0tuβ21F9(Iυ(u),u)du.(12)

Theorem 4.1.

Let Fn: I×R9R are continuous functions and these constants are L1,Fn, L2,Fn,, and L9,Fn>0, such that Sh, Sĥ, S2, S2̂, Im,Im̂, If,If̂, Imf,Imf̂, T,T̂, Sυ,Sυ̂, Eυ,Eυ̂, Iυ,Iυ̂ Φ, where I=[0,T], n=1,2,,9, then we get Fn(U,t)Fn(Û,t)L1,FnShSĥ+L2,FnS2S2̂++L9,FnIυIυ̂.

In addition, suppose that if the condition ΞΘF1+ΞΘF2++ΞΘF9<1 are fulfilled, then system Equation(7) has a unique solution, where ΞΘ={β2(1β1)B(β1)Tβ21+β1Tβ2B(β1)},F1=L1,F1+L2,F1+L3,F1+L4,F1+L5,F1+L6,F1+L7,F1+L8,F1+L9,F1,F2=L1,F2+L2,F2+L3,F2+L4,F2+L5,F2+L6,F2+L7,F2+L8,F2+L9,F2,F3=L1,F3+L2,F3+L3,F3+L4,F3+L5,F3+L6,F3+L7,F3+L8,F3+L9,F3,F4=L1,F4+L2,F4+L3,F4+L4,F4+L5,F4+L6,F4+L7,F4+L8,F4+L9,F4,F5=L1,F5+L2,F5+L3,F5+L4,F5+L5,F5+L6,F5+L7,F5+L8,F5+L9,F5,F6=L1,F6+L2,F6+L3,F6+L4,F6+L5,F6+L6,F6+L7,F6+L8,F6+L9,F6,F7=L1,F7+L2,F7+L3,F7+L4,F7+L5,F7+L6,F7+L7,F7+L8,F7+L9,F7,F8=L1,F8+L2,F8+L3,F8+L4,F8+L5,F8+L6,F8+L7,F8+L8,F8+L9,F8,F9=L1,F9+L2,F9+L3,F9+L4,F9+L5,F9+L6,F9+L7,F9+L8,F9+L9,F9.

Proof.

Let us define suptIF1(0,0,0,0,0,0,0,0,0,t)=ϒF1<, suptIF2(0,0,0,0,0,0,0,0,0,t) =ϒF2<, , suptIF9(0,0,0,0,0,0,0,0,0,t) =ϒF9<. First, we prove that Θ(Sϰ) Sϰ and let Sϰ be closed convex ball (i.e Sϰ={UΘ:Uϰ}). Let Sh,S2,,IυSϰ, we have Θ1(U)β2(1β1)B(β1)Tβ21maxtI(|F1(Sh(t),t)F1(0,0,0,0,0,0,0,0,0,t)|+|F1(0,0,0,0,0,0,0,0,0,t)|)+β1β2B(β1)maxtI0tuβ21(|F1(Sh(u),u)F1(0,0,0,0,0,0,0,0,0,u)|+|F1(0,0,0,0,0,0,0,0,0,u)|)du, (13) β2(1β1)B(β1)Tβ21(L1,F1Sh+L2,F1S2++L9,F1Iυ+ϒF1)+β1B(β)Tβ2(L1,F1Sh+L2,F1S2++L9,F1Iυ+ϒF1)ΞΘF1(ϰ9+ϒF1),ϰ9.(13)

Likewise, we get (14) Θ2(U)ϰ9,Θ3(U)ϰ9,Θ4(U)ϰ9,Θ5(U)ϰ9,Θ6(U)ϰ9,Θ7(U)ϰ9,Θ8(U)ϰ9,Θ9(U)ϰ9,(14) with the use of the Φ definition, with the help of Equationequations (13) and Equation(14), we get (15) Θ(U)=Θ(Sh,S2,,Iυ)ϰ.(15)

When U,ÛΦ, for each tI, we get (16) Θ1(U)Θ1(Û)β2(1β1)B(β1)Tβ21maxtI(|F1(Sh(t),t)F1(Sĥ(t),t)|)+β1β2B(β1)maxtI0tuβ21(|F1(Sh(u),u)F1(Sĥ(u),u)|)du,ΞΘF1UÛ.(16)

Likewise, we get (17) Θ2(U)Θ2(Û)ΞΘF2UÛ,Θ3(U)Θ3(Û)ΞΘF3UÛ,Θ4(U)Θ4(Û)ΞΘF4UÛ,Θ5(U)Θ5(Û)ΞΘF5UÛ,Θ6(U)Θ6(Û)ΞΘF6UÛ,Θ7(U)Θ7(Û)ΞΘF7UÛ,Θ8(U)Θ8(Û)ΞΘF8UÛ,Θ9(U)Θ9(Û)ΞΘF9UÛ.(17)

With the help of Equationequations (16) and Equation(17), then we get (18) Θ(U)Θ(Û)(ΞΘF1+ΞΘF2++ΞΘF9)UU¯.(18)

Since ΞΘF1+ΞΘF2++ΞΘF9<1. So therefore, Θ(U) is a contraction operator. With the use of the Banach contraction theorem and Θ(U) has a unique fixed point. Hence the proposed model Equation(7) has a unique solution.

Theorem 4.2.

Let ζ1,Fn,ζ2,Fn,ζ3,Fn,ζ4,Fn,ζ5,Fn,ζ6,Fn,ζ7,Fn,ζ8,Fn,ζ9,Fn,ζ10,Fn, (n=1,2,,9) :IR+ such that Sh,S2,,IυΦ, we have |Fn(U(t),t)|ζ1,Fn(t)+ζ2,Fn(t)|Sh(t)|+ζ3,Fn(t)|S2(t)|++ζ10,Fn(t)|Iυ(t)|, with suptIζ1,Fn(t)=ζ1,Fn˜, suptIζ2,Fn(t)=ζ2,Fn˜, , suptIζ10,Fn(t)=ζ10,Fn˜ and ζ1,F1˜, ζ1,F2˜, , ζ1,F9˜>0.

Other assumptions are ΞΘ(ζq,F1˜+ζq,F2˜+ζq,F3˜+ζq,F4˜+ζq,F5˜+ζq,F6˜+ζq,F7˜+ζq,F8˜+ζq,F9˜)<1 where q=2,3,,10, and Ξ0=min{1ΞΘ(ζ2,F1˜+ζ2,F2˜++ζ2,F9˜),1ΞΘ(ζ3,F1˜+ζ3,F2˜++ζ3,F9˜),,1ΞΘ(ζ10,F1˜+ζ10,F2˜++ζ10,F9˜)}, then the system Equation(7) has at least one solution.

Proof.

Let Θ:ΦΦ be an operator and completely continuous. We can say that Θ operator is continuous because Fn,(n=1,2,,9) is continuous. Let BΦ be a bounded set and there constants kFn>0, such that, maxtI|Fn(U(t),t)|kFn, UB. We have (19) Θ1(U)β2(1β1)B(β1)Tβ21maxtI|F1(Sh(t),t)|+β1β2B(β1)maxtI0tuβ21|F1(Sh(u),u)|du,ΞΘkF1.(19)

Likewise, we get (20) Θ2(U)ΞΘkF2,Θ3(U)ΞΘkF3,Θ4(U)ΞΘkF4,Θ5(U)ΞΘkF5,Θ6(U)ΞΘkF6,Θ7(U)ΞΘkF7,Θ8(U)ΞΘkF8,Θ9(U)ΞΘkF9.(20)

We proved that Θ(Sh,S2,,Iυ) is uniformly bounded with the use of Equationequations (19) and Equation(20).

Now, we show that Θ is equicontinuous. Let 0t1t2T, therefore (21) Θ1(U(t2))Θ1(U(t1))[|β2(1β1)B(β1)(t2β21t1β21){F1(Sh(t2),,Iυ(t2),t2)F1(Sh(t1),,Iυ(t1),t1)}||β1kF1B(β1)(t2β21t1β21)|]0 whent2t1.(21)

Likewise, we get (22) Θ2(U(t2))Θ2(U(t1))[|β2(1β1)B(β1)(t2β21t1β21){F2(Sh(t2),,Iυ(t2),t2)F2(Sh(t1),,Iυ(t1),t1)}||β1kF1B(β1)(t2β21t1β21)|]0whent2t1,.            .            ..            .            ..            .            .Θ9(U(t2))Θ9(U(t1))[|β2(1β1)B(β1)(t2β21t1β21){F9(Sh(t2),,Iυ(t2),t2)F9(Sh(t1),,Iυ(t1),t1)}||β1kF1B(β1)(t2β21t1β21)|]0 whent2t1.(22)

Thus, Θ(U)=Θ(Sh,S2,,Iυ) is equicontinuous.

So therefore, Θ(Sh,S2,,Iυ) is completely continuous.

Now, we prove that S={UΦ:(Sh,S2,,Iυ)=ςΘ(U),ς[0,1]} is a bounded. Let US, then U=ςΘ(U). When tI, then Sh(t)=ςΘ1(U)(t), S2(t)=ςΘ2(U)(t), Im(t)=ςΘ3(U)(t), If(t)=ςΘ4(U)(t), Imf(t)=ςΘ5(U)(t), T(t)=ςΘ6(U)(t), Sυ(t)=ςΘ7(U)(t), Eυ(t)=ςΘ8(U)(t) and Iυ(t)=ςΘ9(U)(t). Then (23) |Sh(t)|[β2(1β1)B(β1)Tβ21+β1Tβ2B(β1)](ζ1,F1(t)+ζ2,F1(t)|Sh(t)|++ζ10,F1(t)|Iυ(t)|),(23) we simplifying Equationequation (23), we have (24) Sh(t)ΞΘ(ζ1,F1(t)˜+ζ2,F1(t)˜|Sh(t)|++ζ10,F1(t)˜|Iυ(t)|).(24)

We apply a similar process then we get (25) S2(t)ΞΘ(ζ1,F2(t)˜+ζ2,F2(t)˜|Sh(t)|++ζ10,F2(t)˜|Iυ(t)|),.        .        ..        .        ..        .        .Iυ(t)ΞΘ(ζ1,F9(t)˜+ζ2,F9(t)˜|Sh(t)|++ζ10,F9(t)˜|Iυ(t)|).(25)

Now, we add the Equationequations (24) and Equation(25), then we get (26) Sh(t)+S2(t)++Iυ(t)ΞΘ(ζ1,F1(t)˜+ζ1,F2(t)˜++ζ1,F9(t)˜)+ΞΘ(ζ2,F1(t)˜+ζ2,F2(t)˜++ζ2,F9(t)˜)Sh(t).        .        ..        .        ..        .        .+ΞΘ(ζ10,F1(t)˜+ζ10,F2(t)˜++ζ10,F9(t)˜)Iυ(t).(26)

Consequently, we obtain Sh(t),S2(t),,Iυ(t)ΞΘ(ζ1,F1(t)˜+ζ1,F2(t)˜++ζ1,F9(t)˜)Ξ0.

Thus, using the Leray-Schauder fixed point theorem, the proposed model Equation(7) has at least one solution.

4.1. Non-negativity condition

In this section, we prove that the system classes are non-negative for all t. This implies that the co-infection model has non-negative solutions for non-negative initial values for all t > 0.

Lemma 4.1

(Xu et al., Citation2022). Let be suppose that initial condition W(t)0, where W(t)=(Sh,S2,Im,If,Imf,T,Sυ,Eυ,Iυ), for every t > 0 the solution of the system Equation(6) are non-negative. Now, limtZ(t)β2μ, where μ=μh+μν and Z(t)=Sh(t)+S2(t)+Im(t)+If(t)+Imf(t)+T(t)+Sυ(t)+Eυ(t)+Iυ(t).

Proof.

Let t1=sup{t>0:W(t)>0  and W(t)[0,1]} and t1>0. We take the first equation of the system Equation(6), then we get (27) dShdt=πAh+τT(μh+δ+Kf+Kma)Sh.(27)

We solve the Equationequation (27), and we get (28) ddt[Shexp((μh+δ+Kf+Kma)t)]=β2exp((μh+δ+Kf+Kma)t).(28)

We simplified the Equationequation (28), and we get (29) Sh(t1)=Sh(0)exp((μh+δ+Kf+Kma)t1)+β2>0.(29)

The previous similar process applies to other equations in system Equation(6), then we get W(t) > 0 t>0. Consider that 0<Sh,S2,Im,If,Imf,T,Sυ,Eυ,Iυ Z(t). The resulting value is obtained after summing up the state variables in the system Equation(6), we have ddtZ(t)=β2μZ(t).

Hence, limtZ(t)β2μ.

Which indeed completes the proof of the lemma.

Lemma 4.2.

We prove that system Equation(6) is bounded in the feasible region as: R={(Sh,S2,,Iυ)R+9:0Z(t)β2μ}.

Proof.

We have added up all the compartments of the system Equation(6), and we get (30) ddtZ(t)=β2μZ(t),ddtZ(t)+μZ(t)=β2.(30)

We solve the Equationequation (30), we get (31) Z(t)ceμt+β2μ.(31)

When t in Equationequation (31), then we get Z(t)β2μ.

Here, we will explore the positivity of the system Equation(7). To do so, we will follow the previous steps. FFE0D0,tβ1,β2Z(t)=β2μZ(t),

With the help of the previous equation, we get limtZ(t)β2μ.

So, R={(Sh,S2,,Iυ)R+9:0Z(t)β2μ}.

Hence, the proof of the lemma is complete.

4.2. Ulam-Hyer stability condtion

In this section, we establish some terms and conditions of stability for proposed model. Let φ(t) is a perturbed parameter. (i)|φ(t)|ϵ,for ϵ>0, (ii)FFE0D0,tβ1,β2H(t)=F(H(t),t)+φ(t).

Theorem 4.3

(Xu et al., Citation2022). If the following condition hold <1, where =(β2(1β1)Tβ21B(β1)+β2Tβ1B(β1))F and with use of systems (8), (9) and Lemma (2.1), then Ulam-Hyers stability exists for the solution of the proposed model.

Proof.

The proposed model has a unique solution, as we have demonstrated, let HΦ be solution and H¯Φ be a unique solution of the system Equation(7), we have |H(t)H¯(t)|=|H(t){H(0)¯+(F(H¯(t),t)F0(t))β2(1β1)B(β1)tβ21+β1β2B(β1)0tuβ11F(H¯(u),u)du}|,|H(t){H(0)+(F(H(t),t)F0(t))β2(1β1)B(β1)tβ21+β1β2B(β1)0tuβ11F(H(u),u)du}|+|{H(0)+(F(H(t),t)F0(t))β2(1β1)B(β1)tβ21+β1β2B(β1)0tuβ11F(H(u),u)du}||{H¯(0)+(F(H¯(t),t)F0(t))β2(1β1)B(β1)tβ21+β1β2B(β1)0tuβ11F(H¯(u),u)du}|,β1,β2+β2(1β1)Tβ21FB(β1)HH¯+β2Tβ1FB(β1)HH¯,β1,β2+HH¯.

Based on the result mentioned above, we have HH¯β1,β21HH¯.

We can conclude that the system’s solution is stable. So, the proof is finished. □

5. A Numerical technique for malaria – filariasis model

It is not a simple task to deal with nonlinearity when using fractional derivatives in a biological model. Working with non-linearity while using a fractional model is a complex task. We’ve used a few new numerical algorithms to solve biological models in recent years. These numerical techniques play a significant role in determining our system’s approximate solution. We create a fractional system to find an approximate solution in the first stage.

5.1. Numerical scheme with fractal fractional in Caputo sense

We use the model to create a numerical scheme by starting with a power-law scenario. We write the proposed model in terms of Volterra representation in the RL sense before the beginning of the scheme (Khan, Atangana, Muhammad, & Alzahrani, Citation2021). (32) FFP0D0,tβ1,β2F(t)=1Γ(1β1)ddt0t(tu)β1β2tβ21F(u)du,(32)

We are considering the fractional differential equation, outcomes displayed below: (33) RL0D0,tβ1Sh(t)=β2tβ21k1(Sh,t),RL0D0,tβ1S2(t)=β2tβ21k2(S2,t),RL0D0,tβ1Im(t)=β2tβ21k3(Im,t),RL0D0,tβ1If(t)=β2tβ21k4(If,t),RL0D0,tβ1Imf(t)=β2tβ21k5(Imf,t),RL0D0,tβ1T(t)=β2tβ21k6(T,t),RL0D0,tβ1Sυ(t)=β2tβ21k7(Sυ,t),RL0D0,tβ1Eυ(t)=β2tβ21k8(Eυ,t),RL0D0,tβ1Iυ(t)=β2tβ21k9(Iυ,t),(33) where (34) k1(Sh,t)=πAhμhShδShKfShKmaSh+τT,k2(S2,t)=(1π)Ah+KfSh+KmaSh+δShϵσhS2γS2μhS2,k3(Im,t)=ϵσhS2ψImϕ1ImμhImθKfIm,k4(If,t)=ψImγIfϕ2IfμhIfρKmaIf,k5(Imf,t)=θKfIm+ρKmaIfϕ3ImfυϕImfηγImfμhImf,k6(T,t)=ϕ1Im+ϕ2If+υϕImf+ϕ3ImfμhTτT,k7(Sυ,t)=AυKυSυμυSυ,k8(Eυ,t)=KυSυσυEυμυEυ,k9(Iυ,t)=συEυμυIυ.(34)

To develop a numerical scheme for the fractal fractional malaria-filariasis model, we apply the RL fractional integral to the system Equation(33), then we get (35) Sh(t)Sh(0)=β2Γ(β1)0tuβ21(tu)β11k1(Sh,u)du,S2(t)S2(0)=β2Γ(β1)0tuβ21(tu)β11k2(S2,u)du,Im(t)Im(0)=β2Γ(β1)0tuβ21(tu)β11k3(Im,u)du,If(t)If(0)=β2Γ(β1)0tuβ21(tu)β11k4(If,u)du,Imf(t)Imf(0)=β2Γ(β1)0tuβ21(tu)β11k5(Imf,u)du,T(t)T(0)=β2Γ(β1)0tuβ21(tu)β11k6(T,u)du,Sυ(t)Sυ(0)=β2Γ(β1)0tuβ21(tu)β11k7(Sυ,u)du,Eυ(t)Eυ(0)=β2Γ(β1)0tuβ21(tu)β11k8(Eυ,u)du,Iυ(t)Iυ(0)=β2Γ(β1)0tuβ21(tu)β11k9(Iυ,u)du.(35)

Initially, we merely resolve the system’s Equation(35) first equation. Other equations obtain solutions that are analogous to those of the first equation. (36) Sh(t)Sh(0)=β2Γ(β1)0tuβ21(tn+1u)β11k1(Sh,u)du,(36) put t=tn+1, in Equationequation (36) then we get (37) Sh(tn+1)Sh(0)=β2Γ(β1)0tn+1uβ21(tn+1u)β11k1(Sh,u)du.(37)

We simplify the Equationequation (37), we have (38) Sh(tn+1)=Sh(0)+β2Γ(β1)q=0ntqtq+1uβ21(tn+1u)β11k1(Sh,u)du,(38) with the help of the Lagrangian interpolation technique for finding the approximate function uβ21k1(Sh,u) in the interval [tq,tq+1] into Equationequation (38), then we get (39) Bq1(u)=utq1tqtq1tqβ21k1(Sh,q,tq)utqtqtq1tq1β21k1(Sh,q1,tq1).(39)

We apply Equationequation (39) to Equationequation (38), then we get (40) Sh(tn+1)=Sh(0)+β2Γ(β1)q=0ntqtq+1uβ21(tn+1u)β11Bq1(u)du,(40)

EquationEquation (40) can be solved further to produce the following results, (41) Sh(tn+1)=Sh(0)+hβ1β2Γ(β1+2)q=1n[tqβ21k1(Sh,q,tq)en,qtq1β21k1(Sh,q1,tq1)fn,q],(41) where en,q=[(nq+1)β1(nq+β1+2)(nq)β1(nq+2β1+2)],fn,q=[(nq+1)β1+1(nq)β1(nq+β1+1)], n=0,1,2,,N and q=1,2,3,,n.

The previous similar process applies to other equations, then we get (42) S2(tn+1)=S2(0)+hβ1β2Γ(β1+2)q=1n[tqβ21k2(S2,q,tq)en,qtq1β21k2(S2,q1,tq1)fn,q],Im(tn+1)=Im(0)+hβ1β2Γ(β1+2)q=1n[tqβ21k3(Im,q,tq)en,qtq1β21k3(Im,q1,tq1)fn,q],If(tn+1)=If(0)+hβ1β2Γ(β1+2)q=1n[tqβ21k4(If,q,tq)en,qtq1β21k4(If,q1,tq1)fn,q],Imf(tn+1)=Imf(0)+hβ1β2Γ(β1+2)q=1n[tqβ21k5(Imf,q,tq)en,qtq1β21k5(Imf,q1,tq1)fn,q],T(tn+1)=T(0)+hβ1β2Γ(β1+2)q=1n[tqβ21k6(Tq,tq)en,qtq1β21k6(Tq1,tq1)fn,q],Sυ(tn+1)=Sυ(0)+hβ1β2Γ(β1+2)q=1n[tqβ21k7(Sυ,q,tq)en,qtq1β21k7(Sυ,q1,tq1)fn,q],Eυ(tn+1)=Eυ(0)+hβ1β2Γ(β1+2)q=1n[tqβ21k8(Eυ,q,tq)en,qtq1β21k8(Eυ,q1,tq1)fn,q],Iυ(tn+1)=Iυ(0)+hβ1β2Γ(β1+2)q=1n[tqβ21k9(Iυ,q,tq)en,qtq1β21k9(Iυ,q1,tq1)fn,q],(42) where en,q=[(nq+1)β1(nq+β1+2)(nq)β1(nq+2β1+2)],fn,q=[(nq+1)β1+1(nq)β1(nq+β1+1)], n=0,1,2,,N and q=1,2,3,,n.

5.2. Numerical scheme with fractal fractional in CF sense

We now converted the proposed model to the fractal-fractional in the CF sense. Therefore we are developing the numerical approach in the CF sense, the structure as follows: (43) CF0D0,tβ1Sh(t)=β2tβ21k1(Sh,t),CF0D0,tβ1S2(t)=β2tβ21k2(S2,t),CF0D0,tβ1Im(t)=β2tβ21k3(Im,t),CF0D0,tβ1If(t)=β2tβ21k4(If,t),CF0D0,tβ1Imf(t)=β2tβ21k5(Imf,t),CF0D0,tβ1T(t)=β2tβ21k6(T,t),CF0D0,tβ1Sυ(t)=β2tβ21k7(Sυ,t),CF0D0,tβ1Eυ(t)=β2tβ21k8(Eυ,t),CF0D0,tβ1Iυ(t)=β2tβ21k9(Iυ,t).(43)

We apply the CF integral in Equationequation (43), then we get (44) Sh(t)Sh(0)=β2tβ21(1β1)B(β1)k1(Sh,t)+β1β2B(β1)0tuβ21k1(Sh,u)du,S2(t)S2(0)=β2tβ21(1β1)B(β1)k2(S2,t)+β1β2B(β1)0tuβ21k2(S2,u)du,Im(t)Im(0)=β2tβ21(1β1)B(β1)k3(Im,t)+β1β2B(β1)0tuβ21k3(Im,u)du,If(t)If(0)=β2tβ21(1β1)B(β1)k4(If,t)+β1β2B(β1)0tuβ21k4(If,u)du,Imf(t)Imf(0)=β2tβ21(1β1)B(β1)k5(Imf,t)+β1β2B(β1)0tuβ21k5(Imf,u)du,T(t)T(0)=β2tβ21(1β1)B(β1)k6(T,t)+β1β2B(β1)0tuβ21k6(T,u)du,Sυ(t)Sυ(0)=β2tβ21(1β1)B(β1)k7(Sυ,t)+β1β2B(β1)0tuβ21k7(Sυ,u)du,Eυ(t)Eυ(0)=β2tβ21(1β1)B(β1)k8(Eυ,t)+β1β2B(β1)0tuβ21k8(Eυ,u)du,Iυ(t)Iυ(0)=β2tβ21(1β1)B(β1)k9(Iυ,t)+β1β2B(β1)0tuβ21k9(Iυ,u)du.(44)

Initially, we merely resolve the system’s Equation(44) first equation. Other equations obtain solutions that are analogous to those of the first equation. (45) Sh(t)Sh(0)=β2tβ21(1β1)B(β1)k1(Sh,t)+β1β2B(β1)0tuβ21k1(Sh,u)du,(45) we put t= tn+1 in Equationequation (45), then we get (46) Sh(tn+1)Sh(0)=β2tnβ21(1β1)B(β1)k1(Shn,tn)+β1β2B(β1)0tn+1uβ21k1(Sh,u)du.(46)

Now, we simplified Equationequation (46), and we get Sh(tn+1)=Sh(0)+β2tnβ21(1β1)B(β1)k1(Shn,tn)β2tn1β21(1β1)B(β1)k1(Shn1,tn1)+β1β2B(β1)tntn+1uβ21k1(Sh,u)du.

The following outcome is obtained using the Lagrange polynomial concept: (47) Sh(tn+1)=Sh(0)+β2tnβ21(1β1)B(β1)k1(Shn,tn)β2tn1β21(1β1)B(β1)k1(Shn1,tn1)+β1β2hB(β1)[3tnβ212k1(Shn,tn)tn1β212k1(Shn1,tn1)].(47)

Further, we simplify the Equationequation (47), then we get (48) Sh(tn+1)=Sh(0)+β2tnβ21(1β1B(β1)+3β1h2B(β1))k1(Shn,tn)β2tn1β21(1β1B(β1)+β1h2B(β1))k1(Shn1,tn1),(48) the previous similar process applies to other equations, then we get (49) S2(tn+1)=S2(0)+β2tnβ21(1β1B(β1)+3β1h2B(β1))k2(S2n,tn)β2tn1β21(1β1B(β1)+β1h2B(β1))k2(S2n1,tn1),Im(tn+1)=Im(0)+β2tnβ21(1β1B(β1)+3β1h2B(β1))k3(Imn,tn)β2tn1β21(1β1B(β1)+β1h2B(β1))k3(Imn1,tn1),If(tn+1)=If(0)+β2tnβ21(1β1B(β1)+3β1h2B(β1))k4(Ifn,tn)β2tn1β21(1β1B(β1)+β1h2B(β1))k4(Ifn1,tn1),Imf(tn+1)=Imf(0)+β2tnβ21(1β1B(β1)+3β1h2B(β1))k5(Imfn,tn)β2tn1β21(1β1B(β1)+β1h2B(β1))k5(Imfn1,tn1),T(tn+1)=T(0)+β2tnβ21(1β1B(β1)+3β1h2B(β1))k6(Tn,tn)β2tn1β21(1β1B(β1)+β1h2B(β1))k6(Tn1,tn1),Sυ(tn+1)=Sυ(0)+β2tnβ21(1β1B(β1)+3β1h2B(β1))k7(Sυn,tn)β2tn1β21(1β1B(β1)+β1h2B(β1))k7(Sυn1,tn1),Eυ(tn+1)=Eυ(0)+β2tnβ21(1β1B(β1)+3β1h2B(β1))k8(Eυn,tn)β2tn1β21(1β1B(β1)+β1h2B(β1))k8(Eυn1,tn1),Iυ(tn+1)=Iυ(0)+β2tnβ21(1β1B(β1)+3β1h2B(β1))k9(Iυn,tn)β2tn1β21(1β1B(β1)+β1h2B(β1))k9(Iυn1,tn1).(49)

5.3. Error analysis with fractal fractional in Caputo sense

We use the Equationequation (38), and then we get (50) Sh(tn+1)=Sh(0)+β2Γ(β1)q=0ntqtq+1uβ21(tn+1u)β11k1(Sh,u)du,(50) with the help of the Lagrangian polynomial for finding the approximate function k1(Sh,u) in the interval [tq,tq+1] into Equationequation (50), then we get (51) k1(Sh,u)=Pq(u)+E1(u),=k1(Sh,q,tq)Δt(utq1)k1(Sh,q1,tq1)Δt(utq)+(utq)(utq1)2!2u2[k1(Sh,u)]u=yq.(51)

Therefore, the error can be evaluated as (52) E1,uβ1(ϵu)=β2Γ(β1)q=0ntqtq+1uβ21(utq)(utq1)2!2u2[k1(Sh,u)]u=yq(tn+1u)β11du.(52)

Taking the absolute value on both sides, we have (53) |E1,uβ1(ϵu)|=|β2Γ(β1)q=0ntqtq+1uβ212u2[k1(Sh,u)]u=yq(tn+1u)β11du|,β2Γ(β1)q=0nsuptI(utq)(utq1)2!×|2u2[k1(Sh,u)]u=yq|tqtq+1uβ21(tn+1u)β11du.(53)

We have (54) |tqtq+1uβ21(tn+1u)β11du|<2tn+1β1+β21B(β1,β2),<2((n+1)Δt)β1+β21B(β1,β2).(54)

We use Equationequation (54) in Equationequation (53), then we present the following error: (55) |E1,uβ1(ϵu)|<β2Γ(β1)q=0n(utq)(utq1)2!|2u2[k1(Sh,u)]u=yq|2((n+1)Δt)β1+β21B(β1,β2),<2β2((n+1)Δt)β1+β21B(β1,β2)Γ(β1)×q=0n(utq)(utq1)2!sup0utn+1|2u2[k1(Sh,u)]u=yq|.(55)

The previous similar process applies to other equations, then we get (56) |E2,uβ1(ϵu)|<2β2((n+1)Δt)β1+β21B(β1,β2)Γ(β1)×q=0n(utq)(utq1)2!sup0utn+1|2u2[k2(S2,u)]u=yq|,(56) (57) |E3,uβ1(ϵu)|<2β2((n+1)Δt)β1+β21B(β1,β2)Γ(β1)×q=0n(utq)(utq1)2!sup0utn+1|2u2[k3(Im,u)]u=yq|,(57) (58) |E4,uβ1(ϵu)|<2β2((n+1)Δt)β1+β21B(β1,β2)Γ(β1)×q=0n(utq)(utq1)2!sup0utn+1|2u2[k4(If,u)]u=yq|,(58) (59) |E5,uβ1(ϵu)|<2β2((n+1)Δt)β1+β21B(β1,β2)Γ(β1)×q=0n(utq)(utq1)2!sup0utn+1|2u2[k5(Imf,u)]u=yq|,(59) (60) |E6,uβ1(ϵu)|<2β2((n+1)Δt)β1+β21B(β1,β2)Γ(β1)×q=0n(utq)(utq1)2!sup0utn+1|2u2[k6(T,u)]u=yq|,(60) (61) |E7,uβ1(ϵu)|<2β2((n+1)Δt)β1+β21B(β1,β2)Γ(β1)×q=0n(utq)(utq1)2!sup0utn+1|2u2[k7(Sυ,u)]u=yq|,(61) (62) |E8,uβ1(ϵu)|<2β2((n+1)Δt)β1+β21B(β1,β2)Γ(β1)×q=0n(utq)(utq1)2!sup0utn+1|2u2[k8(Eυ,u)]u=yq|,(62) (63) |E9,uβ1(ϵu)|<2β2((n+1)Δt)β1+β21B(β1,β2)Γ(β1)×q=0n(utq)(utq1)2!sup0utn+1|2u2[k9(Iυ,u)]u=yq|.(63)

6. Numerical simulation and result discussion

In this study, an investigation has been conducted to determine the dynamic of antenatal compliant susceptible pregnant women, antenatal non-compliant susceptible pregnant women, malaria-infected pregnant women, filariasis infected pregnant women, malaria-filariasis infected pregnant women, treatment of malaria-filariasis infected pregnant women, susceptible mosquitoes, exposed mosquito and infected mosquito using various fractional orders. To show the efficiency of the proposed strategy, simulations have been carried out using MATLAB (The MathWorks Inc, Citation2016). Through simulations, we have been able to gain a better understanding of the model’s dynamics and perform a more comprehensive analysis by observing how changes in the parameters and initial conditions affected the model’s predictions. The results from the fractional order analysis were found to be more informative and generalizable than those obtained from other related works. We have used the Toufik-Atanagana (TA) numerical techniques to solve the proposed co-infection model. Sh(0)=50,S2(0)=30,Im(0)=10,If(0)=15,Imf(0)=20,T(0)=10, Sv(0)=25,Ev(0)=20,Iv(0)=10 are denoted as the initial conditions of proposed co-infection model and the parameter values are presented in Table as follows.

show the dynamics of antenatal compliant susceptible pregnant women, antenatal non-compliant susceptible pregnant women, malaria-infected pregnant women, filariasis infected pregnant women, malaria-filariasis infected pregnant women, treatment of malaria-filariasis infected pregnant women, susceptible mosquitos, exposed mosquitos and infected mosquitos respectively when fractal dimension β2=1,0.95,0.90,0.85 and fractional order β1=1,0.95,0.90,0.85. Further, when fractional order β1=1 is fixed and fractal dimension is varied then show the dynamics of antenatal compliant susceptible pregnant women, antenatal non-compliant susceptible pregnant women, malaria-infected pregnant women, filariasis infected pregnant women, malaria-filariasis infected pregnant women, treatment of malaria-filariasis infected pregnant women, susceptible mosquitos, exposed mosquitos and infected mosquitos respectively. show the dynamics of antenatal compliant susceptible pregnant women, antenatal non-compliant susceptible pregnant women, malaria-infected pregnant women, filariasis infected pregnant women, malaria-filariasis infected pregnant women andtreatment of malaria-filariasis infected pregnant women respectively when values of natural mortality rate (μh) of pregnant women is varied. show the dynamics of susceptible mosquitos, exposed mosquitos and infected mosquitos when values of natural mortality rate (μv) of mosquitos is varied. and represent the comparison of numerical schemes (Toufik-Atangana schemes Equation(33) and Equation(43) with respect to Caputo and Caputo-Fabrizio operators) for the state variables antenatal compliant susceptible pregnant women, antenatal non-compliant susceptible pregnant women, malaria-infected pregnant women, filariasis infected pregnant women, malaria-filariasis infected pregnant women, treatment of malaria-filariasis infected pregnant women, susceptible mosquitos, exposed mosquitos and infected mosquitos respectively when fractal dimension β2=0.99 and fractional order β1=0.99. It has become clear that the fractal-fractional approach is the most reliable for explaining the disease model, compared to the regular fractional and classical order cases.

Figure 1. Plot for antenatal compliant susceptible pregnant women.

Figure 1. Plot for antenatal compliant susceptible pregnant women.

Figure 2. Plot for antenatal non-compliant susceptible pregnant women.

Figure 2. Plot for antenatal non-compliant susceptible pregnant women.

Figure 3. Plot for malaria infected pregnant women.

Figure 3. Plot for malaria infected pregnant women.

Figure 4. Plot for filariasis infected pregnant women.

Figure 4. Plot for filariasis infected pregnant women.

Figure 5. Plot for malaria-filariasis infected pregnant women.

Figure 5. Plot for malaria-filariasis infected pregnant women.

Figure 6. Plot for treatment of malaria-filariasis infected pregnant women.

Figure 6. Plot for treatment of malaria-filariasis infected pregnant women.

Figure 7. Plot for susceptible mosquito.

Figure 7. Plot for susceptible mosquito.

Figure 8. Plot for exposed mosquito.

Figure 8. Plot for exposed mosquito.

Figure 9. Plot for infected mosquito.

Figure 9. Plot for infected mosquito.

Figure 10. Plot for antenatal compliant susceptible pregnant women.

Figure 10. Plot for antenatal compliant susceptible pregnant women.

Figure 11. Plot for antenatal non-compliant susceptible pregnant women.

Figure 11. Plot for antenatal non-compliant susceptible pregnant women.

Figure 12. Plot for malaria infected pregnant women.

Figure 12. Plot for malaria infected pregnant women.

Figure 13. Plot for filariasis infected pregnant women.

Figure 13. Plot for filariasis infected pregnant women.

Figure 14. Plot for malaria-filariasis infected pregnant women.

Figure 14. Plot for malaria-filariasis infected pregnant women.

Figure 15. Plot for treatment of malaria-filariasis infected pregnant women.

Figure 15. Plot for treatment of malaria-filariasis infected pregnant women.

Figure 16. Plot for susceptible mosquito.

Figure 16. Plot for susceptible mosquito.

Figure 17. Plot for exposed mosquito.

Figure 17. Plot for exposed mosquito.

Figure 18. Plot for infected mosquito.

Figure 18. Plot for infected mosquito.

Figure 19. Plot of antenatal compliant susceptible pregnant women Sh(t) for different values of μh.

Figure 19. Plot of antenatal compliant susceptible pregnant women Sh(t) for different values of μh.

Figure 20. Plot of antenatal non-compliant susceptible pregnant women S2(t) for different values of μh.

Figure 20. Plot of antenatal non-compliant susceptible pregnant women S2(t) for different values of μh.

Figure 21. Plot of malaria infected pregnant women Im(t) for different values of μh.

Figure 21. Plot of malaria infected pregnant women Im(t) for different values of μh.

Figure 22. Plot of filariasis infected pregnant women If(t) for different values of μh.

Figure 22. Plot of filariasis infected pregnant women If(t) for different values of μh.

Figure 23. Plot of malaria-filariasis infected pregnant women Imf(t) for different values of μh.

Figure 23. Plot of malaria-filariasis infected pregnant women Imf(t) for different values of μh.

Figure 24. Plot of susceptible mosquito T(t) for different values of μh.

Figure 24. Plot of susceptible mosquito T(t) for different values of μh.

Figure 25. Plot of antenatal compliant susceptible pregnant women Sv(t) for different values of μv.

Figure 25. Plot of antenatal compliant susceptible pregnant women Sv(t) for different values of μv.

Figure 26. Plot of antenatal non-compliant susceptible pregnant women Ev(t) for different values of μv.

Figure 26. Plot of antenatal non-compliant susceptible pregnant women Ev(t) for different values of μv.

Figure 27. Plot of malaria infected pregnant women Iv(t) for different values of μv.

Figure 27. Plot of malaria infected pregnant women Iv(t) for different values of μv.

Figure 28. Comparison of numerical schemes Equation(33) and Equation(43) for co-infection malaria-filariasis model.

Figure 28. Comparison of numerical schemes Equation(33)(33) RL0D0,tβ1Sh(t)=β2tβ2−1k1(Sh,t),RL0D0,tβ1S2(t)=β2tβ2−1k2(S2,t),RL0D0,tβ1Im(t)=β2tβ2−1k3(Im,t),RL0D0,tβ1If(t)=β2tβ2−1k4(If,t),RL0D0,tβ1Imf(t)=β2tβ2−1k5(Imf,t),RL0D0,tβ1T(t)=β2tβ2−1k6(T,t),RL0D0,tβ1Sυ(t)=β2tβ2−1k7(Sυ,t),RL0D0,tβ1Eυ(t)=β2tβ2−1k8(Eυ,t),RL0D0,tβ1Iυ(t)=β2tβ2−1k9(Iυ,t),(33) and Equation(43)(43) CF0D0,tβ1Sh(t)=β2tβ2−1k1(Sh,t),CF0D0,tβ1S2(t)=β2tβ2−1k2(S2,t),CF0D0,tβ1Im(t)=β2tβ2−1k3(Im,t),CF0D0,tβ1If(t)=β2tβ2−1k4(If,t),CF0D0,tβ1Imf(t)=β2tβ2−1k5(Imf,t),CF0D0,tβ1T(t)=β2tβ2−1k6(T,t),CF0D0,tβ1Sυ(t)=β2tβ2−1k7(Sυ,t),CF0D0,tβ1Eυ(t)=β2tβ2−1k8(Eυ,t),CF0D0,tβ1Iυ(t)=β2tβ2−1k9(Iυ,t).(43) for co-infection malaria-filariasis model.

Figure 29. Comparison of numerical schemes Equation(33) and Equation(43) for co-infection malaria-filariasis model.

Figure 29. Comparison of numerical schemes Equation(33)(33) RL0D0,tβ1Sh(t)=β2tβ2−1k1(Sh,t),RL0D0,tβ1S2(t)=β2tβ2−1k2(S2,t),RL0D0,tβ1Im(t)=β2tβ2−1k3(Im,t),RL0D0,tβ1If(t)=β2tβ2−1k4(If,t),RL0D0,tβ1Imf(t)=β2tβ2−1k5(Imf,t),RL0D0,tβ1T(t)=β2tβ2−1k6(T,t),RL0D0,tβ1Sυ(t)=β2tβ2−1k7(Sυ,t),RL0D0,tβ1Eυ(t)=β2tβ2−1k8(Eυ,t),RL0D0,tβ1Iυ(t)=β2tβ2−1k9(Iυ,t),(33) and Equation(43)(43) CF0D0,tβ1Sh(t)=β2tβ2−1k1(Sh,t),CF0D0,tβ1S2(t)=β2tβ2−1k2(S2,t),CF0D0,tβ1Im(t)=β2tβ2−1k3(Im,t),CF0D0,tβ1If(t)=β2tβ2−1k4(If,t),CF0D0,tβ1Imf(t)=β2tβ2−1k5(Imf,t),CF0D0,tβ1T(t)=β2tβ2−1k6(T,t),CF0D0,tβ1Sυ(t)=β2tβ2−1k7(Sυ,t),CF0D0,tβ1Eυ(t)=β2tβ2−1k8(Eυ,t),CF0D0,tβ1Iυ(t)=β2tβ2−1k9(Iυ,t).(43) for co-infection malaria-filariasis model.

7. Conclusion

In this paper, The fractal-fractional derivative/integral has been used to examine the nonlinear dynamics of the malaria-filariasis model. We have used the Banach contraction theorem to analyze a malaria-filariasis model. The proposed model solution is examined using fixed-point theory to determine its existence and uniqueness. Applying the Ulam-Hyers stability technique, the stability analysis is conducted. We employ the numerical Toufik-Atanagana (TA) approach to offer an analytically estimated solution. We analyze the behaviour of the numerical solution and how it responds to various transmission parameters for a sort of arbitrary order with fractal dimensions. Variations in the state variable and model parameter values give information about the nature of the proposed model. With the help of a graphical representation, it has been demonstrated how the system’s parameters and the order of derivatives will have a significant impact. Climatic variables, ideal controls, and time strategies have affected this disease. The study offers a distinctive perspective on the interactions between malaria and filariasis that will provide valuable insights for readers and public health authorities. Based on the numerical results presented, it can be concluded that the fractal-fractional principle yields higher efficiency than the fractional principle. Therefore, the fractal-fractional approach can be applied to a range of real-world problems to achieve better results. Moving forward, we plan to utilize this approach to analyze other real-world problems. In future, comparing the proposed models’ numerical solution with additional numerical approaches could have potential benefits. To further improve and analyze the model, it can be extended to consider the impact of optimal controls and climatic factors.

Authors contributions

All authors contributed equally and significantly in writing this paper and typed, read, and approved the final manuscript.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statements

Data available on request from the authors.

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