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Expert Opinion on Biological Therapy Volume 8, 2008 - Issue 7
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Future Perspective

Spray drying TB vaccines for pulmonary administration

PB Fourie Chief Scientific Officer Medicine in Need (Mend), MRC Building, PO Box 12660, Queenswood, 0121 Pretoria, South Africa +27 12 3398547; +27 86 6884590; [email protected]
, PhD,
WA Germishuizen Research and Development Manager Medicine in Need (Mend), MRC Building, Pretoria, South Africa
, PhD Pr Eng,
Y-L Wong Scientist Harvard University, School of Engineering and Applied Sciences, Cambridge, MA, USA
, PhD &
DA Edwards Gordon McKay Professor of the Practice of Biomedical Engineering Harvard University, School of Engineering and Applied Sciences, Cambridge, MA, USA
, PhD
Pages 857-863 | Published online: 19 Jun 2008
 
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Abstract

Background: New developments in materials science provide innovative technologies that allow mucosal immunization against tuberculosis. Recent studies report that spray-drying Mycobacterium bovis Bacillus Calmette–Guérin (BCG) allows efficient aerosol delivery of TB vaccines to the lung. Objectives: To consider powder formulation of BCG for inhalation by spray-drying and its potential application to other vaccines given the unique challenges in the process, formulation and delivery. Methods: Description of current advances in spray-drying and aerosol delivery, and its application to preparation of BCG TB vaccine for inhalation. Special consideration is given to physical properties, viability, stability and delivery aspects. Results/conclusion: Spray-drying generates powders with excellent dispersion qualities suitable for targeted delivery to the deep lung. TB vaccine for inhalation prepared by spray-drying is feasible, low-cost and pharmaceutically scaleable.

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