Abstract
Objective: The aim of this study as to unveil changes in serum inflammatory factors in pregnant women with genital tract group B Streptococcus (GBS) infection and their predictive value for premature rupture of membranes (PROM) complicated by chorioamnionitis (CS) and adverse pregnancy outcomes. Methods: The value of serum inflammatory factor levels in predicting PROM complicating CS and adverse pregnancy outcomes in GBS-infected pregnant women was evaluated by ELISA. Results: Serum IL-6, TNF-α, PCT and hs-CRP levels were higher in pregnant women with GBS infection. The combined diagnosis of these factors had excellent diagnostic value in PROM complicating CS and adverse pregnancy outcomes. Conclusion: Joint prediction of IL-6, TNF-α, PCT and hs-CRP has the best predictive value for PROM complicating CS and adverse pregnancy outcomes.
Our study aimed to unveil changes in serum inflammatory factors in pregnant women with group B Streptococcus (GBS) infection and their predictive value for premature rupture of membranes (PROM) complicated by chorioamnionitis (CS) and adverse pregnancy outcomes.
The incidence of PROM was higher in the GBS infection group than in the non-GBS infection group.
High serum IL-6, TNF-α, procalcitonin (PCT) and high-sensitivity CRP (hs-CRP) levels were seen in pregnant women with GBS infection and adverse pregnancy outcomes, as well as GBS-infected pregnant women with PROM complicated by CS.
Serum IL-6, TNF-α, PCT and hs-CRP levels have a certain diagnostic value for PROM complicated by CS and adverse pregnancy outcomes in GBS-infected pregnant women.
The diagnostic value of the joint prediction of each indicator was greater than the individual prediction of each indicator.
This paper may provide a quantitative reference for clinical prediction of the occurrence of PROM complicating CS in GBS-infected pregnant women.
Financial disclosure
This work was supported by Chinese Nutrition Society (CNS) Nutrition Science Foundation – Hyproca Maternal and Infant Nutrition Research Fund (CNS-HPNK2021-93). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
Competing interests disclosure
The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
Writing disclosure
No writing assistance was utilized in the production of this manuscript.
Ethical conduct of research
The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.