Abstract
Aim:
To investigate the association of initial brain natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) with the detection of sepsis-induced myocardial dysfunction (SIMD) in the setting of Sepsis 3.0.
Methods:
Three databases were searched to analyze initial BNP and NT-proBNP levels between SIMD and non-SIMD groups.
Results:
Eighteen studies were included, most of which defined SIMD based on echocardiography. The SIMD group exhibited higher initial BNP and NT-proBNP levels in blood. NT-proBNP higher than a certain cutoff value (>3000 pg/ml) was an independent risk factor for SIMD and its accuracy for SIMD diagnosis was moderate (pooled area under the curve: 0.81).
Conclusion:
Initial blood BNP and NT-proBNP levels are useful to assist in the detection of SIMD and further studies are warranted to determine the SIMD definition.
Tweetable abstract
A meta-analysis with 18 included studies and 2708 patients was conducted to systematically investigate the association of initial brain natriuretic peptide and N-terminal pro-brain natriuretic peptide with the detection of sepsis-induced myocardial dysfunction in the setting of Sepsis 3.0.
Supplementary data
To view the supplementary data that accompany this paper please visit the journal website at: www.tandfonline.com/doi/suppl/10.2217/bmm-2023-0605
Author contributions
B He: data curation, formal analysis and writing (original draft). X Wang: data curation, formal analysis and writing (original draft). L Shi: data curation, formal analysis and software. H Cheng: conceptualization, data curation and writing (review and editing). L Zhao: conceptualization and writing (review and editing).
Financial disclosure
This article is funded by National Science Foundation of China (grant no. 81502509), Science Foundation of Tianjin (grant no. 2014KY04) and Science Foundation of Tianjin (grant no. RC20093).The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
Competing interests disclosure
The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
Writing disclosure
No writing assistance was utilized in the production of this manuscript.