Role of PD-1 and Immune Cells in HSV Infection and Latency

Abstract

A large proportion of the world’s population is infected with HSV-1. Antiviral CD8⁺ T cells and CD8α⁺ dendritic cells are closely related to HSV-1 infection and latency. Latency-associated transcript of HSV-1 and PD-1 are involved in the regulation of latency and reactivation of HSV-1. Here, the role of latency-associated transcript, PD-1, CD8⁺ T cells and CD8α⁺ dendritic cells in HSV-1 infection, the inter-relationships between them and how these interactions lead to latency are discussed, possibly providing new ideas for the treatment of HSV-1 infection.

Plain Language Summary

Antiviral immune cells are closely related to infection and latency of HSV-1. Here, the role of several immune cells in HSV-1 infection, the inter-relationships between them and how these interactions lead to latency are discussed.

Tweetable abstract

Antiviral CD8⁺ T cells and CD8α⁺ dendritic cells are closely related to HSV-1 infection and latency. This special report looks at the role of latency-associated transcript, PD-1, CD8⁺ T cells and CD8α⁺ dendritic cells in HSV-1 infection and their inter-relationships.

Keywords: :

• CD8⁺ T cells
• CD8α⁺ dendritic cells
• HSV
• LAT
• macrophage
• NK cells
• PD-1
• PD-L1

Author contributions

LQ Ding wrote the manuscript, conceived the work and revised the manuscript.

Financial disclosure

This work was supported by the Initial Scientific Research Fund of PhD at Hubei University of Science and Technology (BK202120). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Competing interest disclosure

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Writing disclosure

No writing assistance was utilized in the production of this manuscript.