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Commentary

A long-awaited discovery: hypoxia prevents mouse cells from undergoing spontaneous p53-dependent transformation

Pages 1029-1031 | Published online: 22 Aug 2012
 

Abstract

A recent publication by Phinney and his associates (Citation) has presented a discovery for which the field of cell biology has been waiting for more than half a century: a protocol that makes it possible to expand mouse cells in culture without the cells spontaneously transforming. Amazing though it seems, the secret is simply to grow the cells under hypoxic conditions.

Declaration of interest: The author report no conflicts of interest. The author alone is responsible for the content and writing of the paper.

DJP is chair of the Scientific Advisory Committee of Temple Therapeutics LLC.

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