Advanced search
Publication Cover
Scandinavian Journal of Clinical and Laboratory Investigation Volume 83, 2023 - Issue 8
Submit an article Journal homepage
169
Views
0
CrossRef citations to date
0
Altmetric
Research Articles

Preanalytical impact on the accuracy of measurements of glucagon, GLP-1 and GIP in clinical trials

Christine Rasmussena Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark;b Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkView further author information
,
Michael M. Richtera Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark;b Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkView further author information
,
Nicole J. Jensenc Department of Endocrinology, Bispebjerg University Hospital, Copenhagen, DenmarkView further author information
,
Niklas Heinzb Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;c Department of Endocrinology, Bispebjerg University Hospital, Copenhagen, DenmarkView further author information
,
Bolette Hartmannd Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkView further author information
,
Jens J. Holstd Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark;e Novo Nordic Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkView further author information
,
Sasha A. S. Kjeldsena Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark;b Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkView further author information
&
Nicolai J. Wewer Albrechtsena Department of Clinical Biochemistry, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark;b Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4230-5753View further author information
ORCID Icon show all
Pages 591-598 | Received 16 Aug 2023, Accepted 05 Dec 2023, Published online: 21 Dec 2023

References

  • Wewer Albrechtsen NJ, Holst JJ, Cherrington AD, et al. 100 Years of glucagon and 100 more. Diabetologia. 2023;66(8):1378–1394. doi: 10.1007/s00125-023-05947-y.
  • Holst JJ, Albrechtsen NJW, Rosenkilde MM, et al. Physiology of the incretin hormones, GIP and GLP-1-regulation of release and posttranslational modifications. Compr Physiol. 2019;9(4):1339–1381. doi: 10.1002/cphy.c180013.
  • Plamboeck A, Holst JJ, Carr RD, et al. Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both mediators of the degradation of glucagon-like peptide 1 in the anaesthetised pig. Diabetologia 2005;48(9):1882–1890. doi: 10.1007/s00125-005-1847-7.
  • Hansen L, Deacon CF, Orskov C, et al. Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine. Endocrinology 1999;140(11):5356–5363. doi: 10.1210/endo.140.11.7143.
  • Kjeldsen SA, Hansen LH, Esser N, et al. Neprilysin inhibition increases glucagon levels in humans and mice with potential effects on amino acid metabolism. J. Endocr. Soc. 2021;5(9):bvab084.
  • Holst JJ, Wewer Albrechtsen NJ. Methods and guidelines for measurement of glucagon in plasma. Int J Mol Sci. 2019;20(21):5416. doi: 10.3390/ijms20215416.
  • Bak MJ, Wewer Albrechtsen NJ, Pedersen J, et al. Specificity and sensitivity of commercially available assays for glucagon-like peptide-1 (GLP-1): implications for GLP-1 measurements in clinical studies. Diabetes Obes Metab. 2014;16(11):1155–1164. doi: 10.1111/dom.12352.
  • Bak M, Albrechtsen Wewer N, Pedersen J, et al. Specificity and sensitivity of commercially available assays for glucagon and oxyntomodulin measurement in humans. Eur J Endocrinol. 2014;170(4):529–538. doi: 10.1530/EJE-13-0941.
  • Wewer Albrechtsen NJ, Bak MJ, Hartmann B, et al. Stability of glucagon-like peptide 1 and glucagon in human plasma. Endocr Connect. 2015;4(1):50–57. doi: 10.1530/EC-14-0126.
  • Kjeldsen SAS, Richter MM, Jensen NJ, et al. Development of a glucagon sensitivity test in humans: pilot data and the GLUSENTIC study protocol. Peptides. 2023;161:170938. doi: 10.1016/j.peptides.2022.170938.
  • Orskov C, Rabenhøj L, Wettergren A, et al. Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humans. Diabetes. 1994;43(4):535–539. doi: 10.2337/diab.43.4.535.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.