Plasma metabolomics for diagnostic biomarkers on ectopic pregnancy

References

• Sivalingam VN, Duncan WC, Kirk E, et al. Diagnosis and management of ectopic pregnancy. J Fam Plann Reprod Health Care. 2011;37(4):231–240. doi: 10.1136/jfprhc-2011-0073.
   PubMed Web of Science ®Google Scholar
• Hendriks E, Rosenberg R, Prine L. Ectopic pregnancy: diagnosis and management. Am Fam Physician. 2020;101(10):599–606.
   PubMedGoogle Scholar
• Trabado S, Al-Salameh A, Croixmarie V, et al. The human plasma-metabolome: reference values in 800 French healthy volunteers; impact of cholesterol, gender and age. PLoS One. 2017;12(3):e0173615. doi: 10.1371/journal.pone.0173615.
   PubMed Web of Science ®Google Scholar
• Zhang A, Sun H, Yan G, et al. Metabolomics for biomarker discovery: moving to the clinic. Biomed Res Int. 2015;2015:354671. doi: 10.1155/2015/354671.
   PubMed Web of Science ®Google Scholar
• Zhang A, Sun H, Yan G, et al. Mass spectrometry-based metabolomics: applications to biomarker and metabolic pathway research. Biomed Chromatogr. 2016;30(1):7–12. doi: 10.1002/bmc.3453.
   PubMed Web of Science ®Google Scholar
• Handelman SK, Romero R, Tarca AL, et al. The plasma metabolome of women in early pregnancy differs from that of non-pregnant women. PLoS One. 2019;14(11):e0224682. doi: 10.1371/journal.pone.0224682.
   PubMed Web of Science ®Google Scholar
• Ren JL, Zhang AH, Kong L, et al. Advances in mass spectrometry-based metabolomics for investigation of metabolites. RSC Adv. 2018;8(40):22335–22350. doi: 10.1039/c8ra01574k.
   PubMed Web of Science ®Google Scholar
• Forsberg EM, Huan T, Rinehart D, et al. Data processing, multi-omic pathway mapping, and metabolite activity analysis using XCMS online. Nat Protoc. 2018;13(4):633–651. doi: 10.1038/nprot.2017.151.
   PubMed Web of Science ®Google Scholar
• Libiseller G, Dvorzak M, Kleb U, et al. IPO: a tool for automated optimization of XCMS parameters. BMC Bioinformatics. 2015;16(1):118. doi: 10.1186/s12859-015-0562-8.
   PubMedGoogle Scholar
• Werth MT, Halouska S, Shortridge MD, et al. Analysis of metabolomic PCA data using tree diagrams. Anal Biochem. 2010;399(1):58–63. doi: 10.1016/j.ab.2009.12.022.
   PubMed Web of Science ®Google Scholar
• Saccenti E, Hoefsloot HC, Smilde AK, et al. Reflections on univariate and multivariate analysis of metabolomics data. Metabolomics. 2014;10(3):361–374. doi: 10.1007/s11306-013-0598-6.
   Web of Science ®Google Scholar
• Jurkovic D. hCG as a patient. Ultrasound Obstet Gynecol. 2010;36(4):395–399. doi: 10.1002/uog.8820.
   PubMed Web of Science ®Google Scholar
• Surampudi K, Gundabattula SR. The role of serum beta hCG in early diagnosis and management strategy of ectopic pregnancy. J Clin Diagn Res. 2016;10(7):QC08–10. doi: 10.7860/JCDR/2016/19342.8110.
   PubMedGoogle Scholar
• Connolly A, Ryan DH, Stuebe AM, et al. Reevaluation of discriminatory and threshold levels for serum β-hCG in early pregnancy. Obstet Gynecol. 2013;121(1):65–70. doi: 10.1097/aog.0b013e318278f421.
   PubMed Web of Science ®Google Scholar
• Pang Z, Chong J, Zhou G, et al. MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights. Nucleic Acids Res. 2021;49(W1):388–396.
   PubMed Web of Science ®Google Scholar
• Chaleckis R, Meister I, Zhang P, et al. Challenges, progress and promises of metabolite annotation for LC-MS-based metabolomics. Curr Opin Biotechnol. 2019;55:44–50. doi: 10.1016/j.copbio.2018.07.010.
   PubMed Web of Science ®Google Scholar
• American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins—Gynecology. ACOG practice bulletin no. 193: tubal ectopic pregnancy. Obstet Gynecol. 2018;131(3):91–103.
   PubMedGoogle Scholar
• Eliasson M, Rännar S, Madsen R, et al. Strategy for optimizing LC-MS data processing in metabolomics: a design of experiments approach. Anal Chem. 2012;84(15):6869–6876. doi: 10.1021/ac301482k.
   PubMed Web of Science ®Google Scholar
• Kaplan O, Çelebier M. Evaluation of recent data processing strategies on Q-TOF LC/MS based untargeted metabolomics. Mass Spectrometry Letters. 2020;11(1):1–5.
   Web of Science ®Google Scholar
• Sysi-Aho M, Katajamaa M, Yetukuri L, et al. Normalization method for metabolomics data using optimal selection of multiple internal standards. BMC Bioinf. 2007;8(1):93. doi: 10.1186/1471-2105-8-93.
   PubMedGoogle Scholar
• Worley B, Powers R. Multivariate analysis in metabolomics. Curr Metabolomics. 2013;1(1):92–107. doi: 10.2174/2213235X11301010092.
   PubMedGoogle Scholar
• Brereton RG, Lloyd GR. Partial least squares discriminant analysis: taking the magic away. J Chemom. 2014;28(4):213–225. doi: 10.1002/cem.2609.
   Web of Science ®Google Scholar
• Wishart DS, Guo A, Oler E, et al. HMDB 5.0: the human metabolome database for 2022. Nucleic Acids Res. 20227;50(D1):D622–D631. doi: 10.1093/nar/gkab1062.
   PubMed Web of Science ®Google Scholar
• Berry V, Chanarin I, Booth M, et al. Urinary Formimino-Glutamic acid excretion In pregnancy. Br Med J. 1963;2(5365):1103–1104. doi: 10.1136/bmj.2.5365.1103.
   PubMedGoogle Scholar
• Zalusky R, Herbert V. Urinary formiminoglutamic acid as test of folic-acid deficiency. Lancet. 1962;1:1365–1378
   PubMed Web of Science ®Google Scholar
• Chisholm M, Sharp A. Formimino-Glutamic acid excretion In anaemia Of pregnancy. Br Med J. 1964;2(5421):1366–1369. doi: 10.1136/bmj.2.5421.1366.
   PubMedGoogle Scholar
• Williams GF, Jones DD. Serum deoxycytidylate deaminase as an index of high-risk pregnancy. Br J Obstet Gynaecol. 1982;89(4):309–313. doi: 10.1111/j.1471-0528.1982.tb04702.x.
   PubMedGoogle Scholar
• Baines TJ, Clark A. Cytidine deaminase–a marker for pre-eclampsia? Ann Clin Biochem. 1985;22 (Pt 4)(4):420–422. doi: 10.1177/000456328502200416.
   PubMedGoogle Scholar
• Kostić DA, Dimitrijević DS, Stojanović GS, et al. Xanthine oxidase: isolation, assays of activity, and inhibition. J Chem. 2015;2015:1–8. doi: 10.1155/2015/294858.
   Web of Science ®Google Scholar
• Boss GR, Ragsdale RA, Zettner A, et al. Failure of folic acid (pteroylglutamic acid) to affect hyperuricemia. J Lab Clin Med. 1980;96(5):783–789.
   PubMed Web of Science ®Google Scholar
• Hozyasz KK, Oltarzewski M, Dudkiewicz Z. Malonylcarnitine in newborns with non-syndromic cleft lip with or without cleft palate. Int J Oral Sci. 2010;2(3):136–141. doi: 10.4248/IJOS10047.
   PubMed Web of Science ®Google Scholar
• Baruteau J, Diez-Fernandez C, Lerner S, et al. Argininosuccinic aciduria: recent pathophysiological insights and therapeutic prospects. J Inherit Metab Dis. 2019;42(6):1147–1161. Nov doi: 10.1002/jimd.12047.
   PubMed Web of Science ®Google Scholar
• Tammo O, Uyanikoglu H, Koyuncu İ. Evaluation of plasma free amino acid and carnitine levels in patients with cesarean scar pregnancy. Comb Chem High Throughput Screen. 2021;24(9):1436–1445. doi: 10.2174/1386207323666201019151530.
   PubMed Web of Science ®Google Scholar
• Carey EA, Albers RE, Doliboa SR, et al. AMPK knockdown in placental trophoblast cells results in altered morphology and function. Stem Cells Dev. 2014;23(23):2921–2930. doi: 10.1089/scd.2014.0092.
   PubMed Web of Science ®Google Scholar
• Bayraktar B. Febrile neutropenia following with single-low-dose methotrexate for the treatment of ectopic pregnancy: a case report. Pan Afr Med J. 2021;38:17. doi: 10.11604/pamj.2021.38.17.27507.
   PubMed Web of Science ®Google Scholar
• Baggott JE, Morgan SL, Vaughn WH. Differences in methotrexate and 7-hydroxymethotrexate inhibition of folate-dependent enzymes of purine nucleotide biosynthesis. Biochem J. 1994;300 (Pt 3)(Pt 3):627–629. Pt 3 doi: 10.1042/bj3000627.
   PubMedGoogle Scholar
• Lederman RP, McCann DS, Work B, Jr, et al. Endogenous plasma epinephrine and norepinephrine in last-trimester pregnancy and labor. Am J Obstet Gynecol. 1977;129(1):5–8. doi: 10.1016/0002-9378(77)90809-2.
   PubMed Web of Science ®Google Scholar
• Lederman R, Lederman E, Work B, et al. Plasma epinephrine, norepinephrine, and cortisol of multigravidas in pregnancy and labor and in umbilical cord arteries after delivery. Journal of Psychosomatic Obstetrics & Gynecology. 1989;10(1):57–69. doi: 10.3109/01674828909016678.
   Web of Science ®Google Scholar
• Zachara BA, Wardak C, Didkowski W, et al. Changes in blood selenium and glutathione concentrations and glutathione peroxidase activity in human pregnancy. Gynecol Obstet Invest. 1993;35(1):12–17. doi: 10.1159/000292655.
   PubMed Web of Science ®Google Scholar
• Di Ilio C, Polidoro G, Arduini A, et al. Glutathione peroxidase, glutathione reductase, glutathione S-transferase, and gamma-glutamyltranspeptidase activities in the human early pregnancy placenta. Biochem Med. 1983;29(2):143–148. doi: 10.1016/0006-2944(83)90034-0.
   PubMedGoogle Scholar
• Chen X, Scholl TO, Leskiw MJ, et al. Association of glutathione peroxidase activity with insulin resistance and dietary fat intake during normal pregnancy. J Clin Endocrinol Metab. 2003;88(12):5963–5968. doi: 10.1210/jc.2003-030544.
   PubMed Web of Science ®Google Scholar
• Needleman P, Turk J, Jakschik BA, et al. Arachidonic acid metabolism. Annu Rev Biochem. 1986;55(1):69–102. doi: 10.1146/annurev.bi.55.070186.000441.
   PubMedGoogle Scholar
• Wang B, Wu L, Chen J, et al. Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets. Signal Transduct Target Ther. 2021;6(1):94.
   PubMed Web of Science ®Google Scholar
• Ma L, Li Z, Xi S, et al. Tubal ectopic pregnancy occurrence is associated with high expressions of prokineticin receptors and aberrant secretion of inflammatory cytokines. Am J Transl Res. 2020;12(9):5741–5751.
   PubMed Web of Science ®Google Scholar
• Loriaux DL, Ruder HJ, Knab DR, et al. Estrone sulfate, estrone, estradiol and estriol plasma levels in human pregnancy. J Clin Endocrinol Metab. 1972;35(6):887–891. doi: 10.1210/jcem-35-6-887.
   PubMed Web of Science ®Google Scholar
• Kukor Z, Valent S, Tóth M. Regulation of nitric oxide synthase activity by tetrahydrobiopterin in human placentae from normal and pre-eclamptic pregnancies. Placenta. 2000;21(8):763–772. doi: 10.1053/plac.2000.0584.
   PubMed Web of Science ®Google Scholar
• Bainbridge SA, Smith GN. HO in pregnancy. Free Radic Biol Med. 2005;38(8):979–988. doi: 10.1016/j.freeradbiomed.2004.11.002.
   PubMed Web of Science ®Google Scholar
• Kallen CB. Steroid hormone synthesis in pregnancy. Obstet Gynecol Clin North Am. 2004;31(4):795–816, x. doi: 10.1016/j.ogc.2004.08.009.
   PubMed Web of Science ®Google Scholar
• Yadav R, Yadav N, Kharya MD. Steroid chemistry and steroid hormone action: a review. Asian J Res Chem. 2014;7(11):5.
   Google Scholar
• Spencer TE, Johnson GA, Burghardt RC, et al. Progesterone and placental hormone actions on the uterus: insights from domestic animals. Biol Reprod. 2004;71(1):2–10. doi: 10.1095/biolreprod.103.024133.
   PubMed Web of Science ®Google Scholar
• Walsh SW, Parisi VM. The role of arachidonic acid metabolites in preeclampsia. Semin Perinatol. 1986;10(4):334–355.
   PubMed Web of Science ®Google Scholar
• Kalivodová A, Hron K, Filzmoser P, et al. PLS-DA for compositional data with application to metabolomics. J Chemom. 2015;29(1):21–28. doi: 10.1002/cem.2657.
   Web of Science ®Google Scholar