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Xenobiotica
the fate of foreign compounds in biological systems
Volume 31, 2001 - Issue 6
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Research Article

Disposition of propargyl alcohol in rat and mouse after intravenous, oral, dermal and inhalation exposure

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Pages 357-375 | Published online: 22 Sep 2008

References

  • ARCHER, T. E., 1985, Acute oral toxicity as LD50 (mg/kg) of propargyl alcohol to male and female rats. Journal of Environmental Science and Health, B20, 593–596.
  • BANIJAMALI, A. R., Xu, Y., STRUNK, R. J., GAY, M. H., ELLIS, M. C., PUTTERMAN, G. J. and SUMNER, S. J., 1999, Identification of metabolites of [1,2,3-13 C]propargyl alcohol in rat urine by 13C NMR and mass spectrometry. Journal of Agriculture and Food Chemistry, 47, 1717–1729.
  • BLAKELY, D. H., MAUS, K. L., BELL, R., BAYLEY, J., DOUGLAS, G. R. and NESTMANN, E. R., 1994, Mutagenic activity of 3 industrial chemicals in a battery of in vitro tests. Mutation Research, 320, 273–283.
  • BROWN, R. P., DELP, M. D., LINDSTEDT, S. L., RHOMBERG, L. R. and BELILES, R. P., 1997, Physiological parameter values for physiologically based pharmacokinetic models. Toxicology and Industrial Health, 13, 407.
  • CHANG, J. C. F., GROSS, E. A., SWENBERG, J. A. and BARROW, C. S., 1983, Nasal cavity deposition, histopathology, and cell proliferation after single or repeated formaldehyde exposures in B6C3F1 mice and F-344 rats. Toxicology and Applied Pharmacology, 68, 161–176.
  • DALTON, P. B., HAHNEL, E. C., BRUSIE, J. P. and HORT, E. V., 1963, Alcohols, unsaturated. In A. Standen (ed.), Kirk-Othmer Encyclopedia of Chemical Technology, 2nd edn, vol. 1 (New York: Wiley), pp. 598–618.
  • DEMASTER, E. G., DAHLSEID, T. and REDFERN, B., 1994, Comparative oxidation of 2-propyn-1-ol with other low molecular weight unsaturated and saturated primary alcohols by bovine liver catalase in vitro. Chemical Research in Toxicology, 7, 414–419.
  • DEMASTER, E. G., SHIROTA, F. N. and NAGASAWA, H. T., 1986, Role of propialdehyde and other metabolites in the pargyline inhibition of rat liver aldehyde dehydrogenase. Biochemical Pharmacology, 35, 1481–1489.
  • HAZARDOUS SUBSTANCE DATA BANK, 2000, U.S. National Library of Medicine, http://chem.sis.nlm.nih. gov/hsdb.
  • LINGTON, A. W. and BEVAN, C., 1994, Alcohols. In G. D. Clayton and F. E. Clayton (eds), Patty's
  • Industrial Hygiene and Toxicology, 4th edn, vol. II, Part D (New York: Wiley), pp. 2585–2759. NATIONAL RESEARCH COUNCIL, 1996, Guide for the Care and Use of Laboratory Animals (Washington, DC: National Academy Press).
  • NimoLs, C. S. and CROMARTIE, T. H., 1980, Irreversible inactivation of the fiavoenzyme alcohol oxidase with acetylenic alcohols. Biochemical and Biophysical Research Communication, 97, 216–221.
  • RUBINSTEIN, R., IRENE, S., SONOWANE, B., DEROSA, C. and BATHIJ A., 1989,30 and 90 day rat oral toxicity of propargyl alcohol. Toxicologist, 9, 248.
  • SLAUTER, R. W., COLEMAN, D. P., GAUDETTE, N. F., McKEE, R. H., MASTEN, L. W., GARDINER, T. H., STROTHER, D. E., TYLER, T. R. and JEFFCOAT, A. R., 1994, Disposition and pharmacokinetics of isopropanol in F-344 rats and B6C3F1 mice. Fundamental and Applied Toxicology, 23, 407–420.
  • VERNOT, E. H., MACEWEN, J. D., HAUN, C. C. and KINKEAD, E. R., 1977, Acute toxicity and skin corrosion data for some organic and inorganic compounds and aqueous solutions. Toxicology and Applied Pharmacology, 42, 417–423.
  • Zissu, D., 1995, Histopathological changes in the respiratory tract of mice exposed to ten families of airborne chemicals. Journal of Applied Toxicology, 15(3), 207–213.

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